Results 61 to 70 of about 167,453,715 (202)

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans’ islets, directly initiates NLRP3 inflammasome activation

International Journal of Immunopathology and Pharmacology, 2018
Recent findings revealed that type 2 diabetes mellitus (T2D) is a chronic inflammatory disease and an islet amyloid polypeptide (IAPP)/amylin, is deposited within pancreatic islets.
Shinnosuke Morikawa, Naoe Kaneko, Chikara Okumura, Haruka Taguchi, Mie Kurata, Toshihiro Yamamoto, Haruhiko Osawa, Ayaka Nakanishi, Tamotsu Zako, Junya Masumoto   +9 more
doaj   +1 more source

Transplantation or islets of Langerhans: new developments

Swiss Medical Weekly, 2001
The clinical results recently reported by the Edmonton group in recipients of allogeneic islet grafts, all of whom achieved at least temporary insulin independence, has rekindled interest in transplantation of islets of Langerhans as a means to cure diabetes.
A Caulfield, J Oberholzer, R Alejandro, DKC Cooper, C Ricordi   +4 more
doaj   +3 more sources

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

Molecular Metabolism, 2022
Objective: Identifying the transcripts which mediate genetic association signals for type 2 diabetes (T2D) is critical to understand disease mechanisms. Studies in pancreatic islets support the transcription factor ZMIZ1 as a transcript underlying a T2D ...
Tamadher A. Alghamdi, Nicole A.J. Krentz, Nancy Smith, Aliya F. Spigelman, Varsha Rajesh, Alokkumar Jha, Mourad Ferdaoussi, Kunimasa Suzuki, Jing Yang, Jocelyn E. Manning Fox, Han Sun, Zijie Sun, Anna L. Gloyn, Patrick E. MacDonald   +13 more
doaj   +1 more source

Assessing Extracellular Vesicle Proteins as Predictive Biomarkers for Developing Type 1 Diabetes

PROTEOMICS, Volume 26, Issue 10, Page 24-30, October 2026.
ABSTRACT Plasma extracellular vesicles (EVs) are considered excellent sources for biomarker discovery since they carry signatures of their cellular origin and disease processes. In this paper, we evaluate the potential of plasma EV proteomics analysis for identifying predictive biomarkers of developing type 1 diabetes (T1D), which results from ...
Panshak P. Dakup, Lisa M. Bramer, Athena Schepmoes, Ivo Diaz Ludovico, Javier Flores, Raghavendra G. Mirmira, Bobbie‐Jo M. Webb‐Robertson, Thomas O. Metz, Emily K. Sims, Ernesto S. Nakayasu   +9 more
wiley   +1 more source

d‐Sorbose Promotes Regulatory T‐Cell Differentiation and Ameliorates Autoimmune and Allergic Diseases via Hexosamine Biosynthetic Pathway Inhibition

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
d‐Sorbose promotes Foxp3+ Treg differentiation ex vivo and exerts potent anti‐inflammatory effects in vivo, ameliorating allergic airway inflammation and preventing autoimmune diabetes without compromising T cell viability or inducing toxicity.
Fumiaki Sato, Masato Hoshi, Hiroyuki Yokoi, Sayaka Yoshida, Ryosuke Takenaka, Nao Shimoga, Nanaka Morita, Chieko Tashita, Kyoka Yamazaki, Yuka Kishimoto, Hiroyuki Tezuka, Hiroyasu Ito, Kuniaki Saito   +12 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, Volume 600, Issue 18, Page 2716-2728, September 2026.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Morphological Features of Tyrosine Hydroxylase Immunoreactive Cells in the Mouse Islets of Langerhans [PDF]

, 2012
The current immunohistochemical study used the antibody against tyrosine hydroxylase (TH) to observe the immunoreactive elements in the mouse pancreas. The results indicated the presence of immunoreactive nerve fibers and endocrine cells.
Gesase, AP, Satoh, Y-I
core   +1 more source

IL‐22Rα1 restrains pancreatic injury independently of its C‐terminal STAT3‐amplifying domain

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
IL‐22R, and to a lesser extent IL‐22, are key drivers of protection in acute pancreatitis. Although the C‐terminal domain of IL‐22R enhances STAT3 activation in the pancreas, it is not required for disease protection. Classical IL‐22R signaling alone is sufficient to control inflammation and promote pancreatic recovery.
Léna Puigdevall, Clara Stewardson, Lysa Dhulst, Emilie Hendrickx, Laure Dumoutier   +4 more
wiley   +1 more source