Results 61 to 70 of about 24,397 (218)

Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues. Among the critical steps in MALDI–MSI workflows, matrix deposition significantly influences sensitivity, spatial
Toufik Mahamdi, Oscar Yanes
wiley   +1 more source

Sensing and Communicating β‐Cell Stress in the Context of T1D Etiology: New Opportunities for Therapeutic Impact

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Type 1 diabetes (T1D) results from the immune‐mediated destruction of insulin‐producing pancreatic β‐cells. Recent human studies show that early β‐cell stress maladaptations precede overt immune cell infiltration. DOC2B, a vesicle secretion regulatory protein that supports β‐cell functionality and resilience against stress, declines early in T1D ...
Diana Esparza, Chathurani S. Jayasena, Tijana Jovanovic‐Talisman, Debbie C. Thurmond   +3 more
wiley   +1 more source

In Vivo Imaging of Transplanted Pancreatic Islets

Frontiers in Endocrinology, 2018
The beta-cells in the islets of Langerhans in the pancreas secrete insulin and play an important role in glucose homeostasis. Diabetes, characterized by hyperglycemia, results from an absolute or a relative deficiency of the pancreatic beta-cell mass ...
Donghee Kim, Hee-Sook Jun, Hee-Sook Jun, Hee-Sook Jun   +3 more
doaj   +1 more source

Streptozotocin induced hyperglycemia in the axolotl

Developmental Dynamics, Volume 255, Issue 6, Page 567-584, June 2026.
Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen, Anita Dittrich, Henrik Lauridsen   +2 more
wiley   +1 more source

Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis

Nature Communications, 2022
How pancreatic islets of Langerhans are built during development is incompletely understood. Here the authors find that Synaptotagmin-13 mediates remodeling of cell-matrix adhesion to regulate endocrine cell egression and islet morphogenesis.
Mostafa Bakhti, Aimée Bastidas-Ponce, Sophie Tritschler, Oliver Czarnecki, Marta Tarquis-Medina, Eva Nedvedova, Jessica Jaki, Stefanie J. Willmann, Katharina Scheibner, Perla Cota, Ciro Salinno, Karsten Boldt, Nicola Horn, Marius Ueffing, Ingo Burtscher, Fabian J. Theis, Ünal Coskun, Heiko Lickert   +17 more
doaj   +1 more source

The Endothelial Cells in Islets of Langerhans [PDF]

Upsala Journal of Medical Sciences, 2005
The blood vessels of the pancreatic islets are of crucial importance for oxygen and metabolite supply, and dispersal of secreted hormones. In addition to this, endothelial cells have an important role in the revascularization process after islet transplantation.
openaire   +2 more sources

The Islets of Langerhans in Relation to Diabetes [PDF]

Biochemical Journal, 1907
The work recorded in the following paper was undertaken with a view to testing the hypothesis frequently brought forward that the islets of Langerhans of the pancreas yield an internal secretion whose function has some relation to the utilization of dextrose in the vertebrate organism. The primary cause of diabetes is, according to Macleod,1 the ' want
J, Rennie, T, Fraser
openaire   +2 more sources

Nutraceutical Evaluation of Biscuits Formulated From Acha, Chia, and Soycake Flours on Glycemic Control, Lipid Profile, and Histopathological Effects in High‐Fat Diet/Streptozotocin‐Induced Type 2 Diabetic Rats

Food Chemistry International, Volume 2, Issue 2, Page 164-174, June 2026.
Acha–chia–soycake biscuits improved glucose tolerance, lipid profile, insulin levels, and pancreatic integrity in HFD–STZ diabetic rats. ACSB1 and ACSB13 outperformed acarbose, showing potent antihyperglycemic, hypolipidemic, and pancreatic‐protective effects.
Oluwafunmilayo Christianah Ogunnowo, Olufunmilayo Sade Omoba, Aderonke Ibidunni Olagunju, Olamide Wilson Fasakin, Idowu Sunday Oyeleye, Olajide Raymond Ojo   +5 more
wiley   +1 more source

The use of VpSP37 provides viable Islets of Langerhans.

, 2015
(A) After pancreas disgregation, cells were stained with Dithizone to identify the Islets (marked by the arrow) as described in Materials and Methods section. (B) Islets of Langerhans were purified and cultured on selected media.
Monica Salamone (768136), Aldo Nicosia (633613), Angela Cuttitta (633616), Paola Quatrini (768138), Salvatore Mazzola (426101), Carmelo Bennici (768137), Valentina Catania (768139), Giulio Ghersi (768140)   +7 more
core   +1 more source

Evaluating the Influence of Flaxseed Oil Against Docosahexaenoic Acid on Cancer Antigen CA15‐3, Biochemical and Histopathological Parameters of DMBA‐Induced Mammary Tumors Female Albino Wistar Rats

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Flaxseed oil and docosahexaenoic acid administered to female Wistar rats with DMBA‐induced breast cancer help increase the HDL cholesterol and significantly reduce the CA15‐3, AST, ALT, LDL, and creatinine levels of rats compared to the negative control group. They also exhibited a protective effect on organs from histopathological data.
Hilda Nji Aza, Fabrice Tonfack Djikeng, Achidi Aduni Ufuan, Ines Sorelle Fotsing, Stephane Zingue   +4 more
wiley   +1 more source