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Cryopreservation of islets of Langerhans

Cryobiology, 1981
Abstract Development of techniques for cryopreservation of pancreatic islets of Langerhans could potentially allow for increased freedom from the time restrictions presently affecting viability in islet cell transplantation. While several investigators have attempted islet cell freezing and have obtained favorable in vitro results after thawing ...
L H, Toledo-Pereyra   +2 more
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Islets of Langerhans

2015
Adult stem cells are unspecialized cells with the capacity to differentiate into many different cell types in the body. These cells together with the progenitor cells involve in the tissue repair processes and maintain the functionality of the tissue in which they are found.
Karaöz, Erdal, Duruksu, Gökhan
openaire   +3 more sources

Vitrification of human islets of Langerhans

Cryobiology, 1987
Cryopreservation of human islets of Langerhans by vitrification was studied. Isolated islets were divided into four groups: (1) control islets which were cultured for 6 days, (2) islets which were vitrified after 2 days of culture, (3) control islets which were cultured for 10-13 days, and (4) islets which were vitrified after 6-9 days of culture ...
N H, Jutte   +4 more
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Multiple Transplantations of Islets of Langerhans

European Surgical Research, 1977
In 6 diabetic rats about 1,000 isolated islets of Langerhans were transplanted into the liver with little effect on the uninsulinism and hyperglycemia. Subsequently, a second transplantation resulted in a decrease of blood sugar to normal and in a reversal of the loss in body weight. Finally, in animals who had reversed to diabetes again, a third islet
K D, Rumpf, D, Löhlein, , Pichlmayr
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Glucoreceptor Mechanisms in Islets of Langerhans

Diabetes, 1972
A widely accepted concept has been that metabolites of glucose or factors associated with glucose metabolism, rather than glucose itself, trigger insulin release from the β cells. If this concept is correct, levels of metabolites or cofactors or of both should change within seconds of the glucose pulse.
F M, Matschinsky   +3 more
openaire   +2 more sources

Paracrine Interactions Within Islets of Langerhans

Journal of Molecular Neuroscience, 2012
Glucose supply fluctuates between meal and fasting periods and its consumption by the body varies greatly depending on bodily metabolism. Pancreatic islets of Langerhans secrete various endocrine hormones including insulin and glucagon to keep blood glucose level relatively constant.
Duk-Su, Koh   +2 more
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GABA production in rat islets of Langerhans

Diabetes, 1993
Homogenates of pancreatic islets catalyzed breakdown of L-glutamate to GABA with a rate of 0.24 ± 0.04 nmol · min−1 · mg−1 protein at 37°C. The formation of GABA was stimulated by addition of pyridoxal phosphate in the range 0.05–1 microM (0.97 ± 0.02 nmol · min−1 · mg protein-1 at a saturating cofactor concentration), which indicates that the process ...
M, Michalik, J, Nelson, M, Erecińska
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[Islet of Langerhans transplantation].

Annales de chirurgie, 1996
Islet of Langerhans transplantation is considered to be the ideal treatment for type I insulin-dependent diabetes. The permanent and adapted insulin secretion obtained by this method ensures prevention or even regression of the degenerative lesions which now constitute the severity of this frequent disease.
K, Boudjema, E, Alexandre
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WHY ARE THE ISLETS OF LANGERHANS ?

The Lancet, 1969
Abstract In the course of evolution, endocrine pancreatic tissue has moved away from its origin in the gut and become distributed throughout the exocrine pancreas as the islets of Langerhans. It is suggested that this is not an evolutionary accident, but that high local concentrations of islet hormones play a significant role in the metabolism of the ...
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Factors Influencing Isolation of Islets of Langerhans

Diabetes, 1989
More efficient methods of islet isolation must be developed for islet transplantation to become clinically routine. During collagenase dispersal of human pancreas, an amorphous, viscous, gellike material often develops and entraps large numbers of islets, thereby reducing the yield.
G A, Burghen, L R, Murrell
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