Results 81 to 90 of about 12,558 (256)
Islet Assessment for Transplantation [PDF]
, 2009 Author Manuscript: 2010 December 1.Purpose of review: There is a critical need for meaningful viability and potency assays that characterize islet preparations for release prior to clinical islet cell transplantation (ICT).
Colton, Clark K. +2 more
core +1 more source
From Lymphotoxin to Tertiary Lymphoid Structures and Beyond
Immunological Reviews, Volume 335, Issue 1, October 2025.ABSTRACT Lymphoid organ development occurs in ontogeny in the absence of antigenic stimulation; inflammation occurs after some immunological insult. These subjects had originally been considered as separate fields of research. Inflammation is due to inflammatory mediators such as lymphotoxin (LT) and its close relative, tumor necrosis factor (TNF). The
Nancy H. Ruddle
wiley +1 more source
Human islet transplantation - state of the art [PDF]
Einstein (São Paulo), 2005 Currently, only vascularized pancreas transplantation can reestablishlong-term normoglycemia but the scenario has beenassociated with significant morbidity and mortality.
Eleazar Chaib +4 more
doaj
Encapsulation of Langerhans' islets: Microtechnological developments for transplantation
Engineering in Life Sciences, 2011 AbstractThere is an increasing trend to apply microsystems and microfluidics to solve medical and biomedical tasks. Microfluidic modules are used to modify and manipulate cells and cell clusters for therapeutic applications. Specifically, a method and technical system for encapsulation of Langerhans' islets as an option for the future treatment of ...
Stefan Wiedemeier +7 more
openaire +1 more source
Pancreatic Islet Cell Hormones: Secretion, Function, and Diabetes Therapy
MedComm, Volume 6, Issue 9, September 2025.The pancreatic islets, composed of α, β, δ, ε, and PP cells, play a central role in maintaining glucose homeostasis. This review examines the mechanisms of islet hormone secretion and their functional crosstalk networks, alongside the pathophysiology of diabetes driven by hormonal dysregulation.
Jinfang Ma +8 more
wiley +1 more source
The Islet Size to Oxygen Consumption Ratio Reliably Predicts Reversal of Diabetes Posttransplant
Cell Transplantation, 2012 β-Cell replacement therapy by either whole-organ pancreas or islets of Langerhans transplantation can restore carbohydrate control to diabetic patients and reduces complications associated with the disease.
Andrew R. Pepper +6 more
doaj +1 more source
Intraocular in vivo imaging of pancreatic islet cell physiology/pathology
Molecular Metabolism, 2017 Background: Diabetes mellitus has reached epidemic proportions and requires new strategies for treatment. Unfortunately, the efficacy of treatment regimens on maintaining/re-gaining functional beta cell mass can, at the present, only be determined ...
Ingo B. Leibiger, Per-Olof Berggren
doaj +1 more source
Journal of Pineal Research, Volume 77, Issue 5, September 2025.ABSTRACT Disruptions in circadian rhythm, partly controlled by the hormone melatonin, increase the risk of type 2 diabetes (T2D). Accordingly, a variant of the gene encoding the melatonin receptor 1B (MTNR1B) is robustly associated with increased risk of T2D.
Tania Singh +14 more
wiley +1 more source
The liver surface as a favorable site for islet cell sheet transplantation in type 1 diabetes model mice [PDF]
, 2018 Introduction: Islet transplantation is one of the most promising therapeutic approaches for patients with severe type 1 diabetes mellitus (T1DM). Transplantation of engineered islet cell sheets holds great potential for treating T1DM as it enables the ...
Fujita Izumi +4 more
core +3 more sources
Follow-up Study of the Revascularization Process of Purified Rat Islet Beta-Cell Grafts
Cell Transplantation, 1997 The revascularization of islets of Langerhans transplanted in heterotopic sites like the liver by portal vein embolization or the renal subcapsular space is a major process necessary for the viability of grafted cells.
José F. Mendola +6 more
doaj +1 more source