Results 31 to 40 of about 2,489 (185)

Fucosylation limits ADCC in clinically used anti‐RhD monoclonal antibodies

Transfusion, EarlyView.
Abstract Background Haemolytic disease of the fetus and newborn (HDFN) is caused by maternal alloantibodies, often targeting the D antigen on fetal red blood cells. Maternal immunization is preventable with timely administration of anti‐D polyclonal antibodies (pAbs).
Gabriela Koike, Albert Bondt, Douwe Schulte, Rien Leuvenink, Dirk Jan Mons, Peter C. Ligthart, E. Joanne T. Verweij, AFRICARhE Consortium, Enrico Lopriore, E. J. T. Joanne Verweij, Tienke Vermeiden, Thomas van den Akker, C. Ellen van der Schoot, Derek P. de Winter, Renske van Oever, Abera Kenay Tura, Tadesse Gure, Assefa Desalew, Tewodros Tesfa, Konjit Eshetu, Jeremia Pyuza, Rafiki N. Mjema, Priscus John Mapendo, Jeremiah John Hhera, Bariki Mchome, Patricia Swai, Blandina T. Mmbaga, Aisa Shayo, Peter Moons, Kondwani Kawaza, Luis Gadama, Albert J. R. Heck, C. Ellen van der Schoot, Gestur Vidarsson   +33 more
wiley   +1 more source

D‐Alloantibody Titration Assessment Study: In Search of a Common Antibody Titration Platform—A BEST Collaborative Study

Transfusion, EarlyView.
Abstract Background Alloimmunization against D‐antigen can cause severe Hemolytic Disease of the Fetus and Newborn (HDFN). Traditionally, anti‐D‐titers are measured using a saline indirect antiglobulin test (tube testing). Anti‐D‐titers ≥8 during pregnancy trigger an escalation in maternal care. Tube testing is labor‐intensive and known for imprecision.
Fatima A. Aldarweesh, Rim Abdallah, Ingrid Perez Alvarez, Jennifer Andrews, Therese M. Chlebeck, Jessica Clower, Aisling Costelloe, Dolores Figueroa, Chloe George, Michael Evans, Sarah Ilstrup, Ellen B. Klapper, Angela Mueller, Hannah Peterson, Terry Rees, Jina Seo, Arrey N. Takang, Claudia S. Cohn, on behalf of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative   +18 more
wiley   +1 more source

Demand for human leukocyte antigen or human platelet antigen‐selected platelets: An observational study at Canadian Blood Services

Transfusion, EarlyView.
Abstract Background Platelet transfusion refractoriness (PTR) is a clinically important condition. The Human Leukocyte Antigen and Human Platelet Antigen (HLA/HPA) Platelet Program at Canadian Blood Services (CBS) provides platelet products to support such patients.
Natasha Rickards, Phuoc‐An Duong Hoang, Johnathan Mack, Matthew Seftel, John T. Blake, Akash Gupta   +5 more
wiley   +1 more source

Suppression of RBC alloimmunization and regulation of CD4+T cell dependence by C3 is not due to genetic confounders in mice

Transfusion, EarlyView.
Abstract Background Activation of complement protein C3 generally enhances antibody responses and C3‐null mice have decreased antibody‐based immunity. Mener et al. have reported a paradoxical suppressor function for C3 in alloimmunization to transfused RBCs as alloantibodies are increased in C3‐null mice.
Arijita Jash, Ariel Hay, James C. Zimring   +2 more
wiley   +1 more source

Antenatal risk estimation for exchange transfusions in neonates with hemolytic disease of the fetus and newborn in a changing treatment landscape: A multicenter, retrospective cohort study

Transfusion, EarlyView.
Abstract Background Neonates with hemolytic disease of the fetus and newborn (HDFN) may require exchange transfusions (ET) for severe hyperbilirubinemia. We evaluated if ET in neonates with HDFN was associated with the maximum maternal titer and antibody‐dependent cellular cytotoxicity (ADCC) and we determined the change in the number of hospitals ...
Derek P. de Winter, Masja de Haas, Christian V. Hulzebos, Michaël V. Lukens, Sandra A. Prins, Jasper V. Been, Esther J. d'Haens, Daniël C. Vijlbrief, Sabine L. A. G. Vrancken, Amanda M. P. Trompenaars, Huib Ceelie, Lieke M. J. van Zogchel, Annemiek M. C. P. Joosen, Clemens B. Meijssen, J. L. A. M. van Hillegersberg, Janneke C. Zant, Maaike C. van Rossem, Ron van Beek, Helene G. Stas, Clare E. Counsilman, F. R. Knol, I. A. M. Schiering, Gerdina H. Dubbink‐Verheij, E. J. T. Verweij, Enrico Lopriore, for the WISE investigators, Ron van Beek, A.J. (Adriaan) van Gammeren, Sandra A. Prins, J.H. Klinkspoor, Jasper V. Been, Henk Russcher, Clare E. Counsilman, Sietske Hogenboom, Huib Ceelie, Angelique Hoffmann‐Haringsma, Gerdina H. Dubbink‐Verheij, Jacques J.H. Hens, Esther J. d'Haens, Gijs den Besten, Lieke M.J. van Zogchel, N.C.V. Péquériaux, Derek P. de Winter, E.J.T. (Joanne) Verweij, Masja de Haas, Enrico Lopriore, Helene G. Stas, Floor Weerkamp, Amanda M.P. Trompenaars, Tinta J.F. Lebon, Annemiek M.C.P. Joosen, Peter Andriessen, Clemens B. Meijssen, Karlijn Gijzen, F.R. Knol, Janneke C. Zant, Geert Jan Blok, Sabine L.A.G. Vrancken, Annegeet van den Bos, Maaike C. van Rossem, Jolanda Lamberts, I.A.M. Schiering, Claudia Admiraal, J.L.A.M. van Hillegersberg, Daniël C. Vijlbrief, Karen M.K. De Vooght, Christian V. Hulzebos, Michaël V. Lukens   +67 more
wiley   +1 more source

Cost‐effectiveness of a hypothetical assay to evaluate stored blood quality prior to transfusion

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Unsuccessful red blood cell (RBC) transfusion, necessitating unscheduled repeat transfusion, is common and costly. Several technologies have been developed to assess stored blood quality, but the potential cost‐effectiveness of pretransfusion testing versus no testing to prevent unscheduled re‐transfusion is unknown ...
Melissa C. Caughey, Tara Templin, Nareg H. Roubinian, Matthew S. Karafin   +3 more
wiley   +1 more source

Emergence of red blood cell alloantibodies and transfusion management in patients with warm autoantibodies at a tertiary care centre in British Columbia, Canada

Vox Sanguinis, EarlyView.
Abstract Background and Objectives The presence of warm autoantibodies (WAAs) complicates pre‐transfusion and compatibility testing. Despite attempts to provide antigen‐matched red blood cells (RBCs), the risk of alloimmunization remains. Rates of alloimmunization and indications for transfusion were reviewed to streamline testing and RBC provision ...
S. Hutspardol, J. Mi, C. Denesiuk, D. Kalar, L. Sham, M. Roche, J. R. Tsu, D. Lam, M. T. S. Yan   +8 more
wiley   +1 more source

Impact of Isovolemic Hemodilution‐Red Cell Exchange on Health‐Related Quality of Life in Patients With Sickle Cell Disease: A Pilot Study

Journal of Clinical Apheresis, Volume 41, Issue 1, February 2026.
ABSTRACT Sickle cell disease (SCD) negatively affects health‐related quality of life (HRQoL). Isovolemic hemodilution (IHD) red‐cell exchange (RCE) is being increasingly used to treat SCD‐related complications, but its impact on HRQoL has not been characterized.
Alistair Murray, Davinder Sidhu, Natalia Rydz, Dawn Goodyear, Kelsey Uminski   +4 more
wiley   +1 more source

CD71+ Red Blood Cells Mediate Increased Erythrophagocytosis and Reduce Monocyte Number in a Monocyte Suspension Assay

Scandinavian Journal of Immunology, Volume 103, Issue 2, February 2026.
CD71+ RBCs promote erythrophagocytosis in a dose‐dependent manner and induce loss of monocytes. ROS scavenger‐treated CD71+ RBCs rescue the impact of CD71+ RBCs on phagocytosis and monocyte reduction. ABSTRACT Adverse reactions from donor‐recipient sex‐mismatched transfusions have been reported in the field of transfusion medicine.
Wenhui Li, Jason P. Acker
wiley   +1 more source

Cytotoxic Isoantibodies and Immunologic Enhancement in Mice.

Experimental Biology and Medicine, 1966
Summary1. Cytotoxic isoantibodies and hemagglutinins are stimulated in response to H-2 isoantigenic differences between graft and host in mice. 2. This study offers data correlating cytotoxic isoantibody and immunological enhancement. 3. The mechanism of immunological enhancement has been shown to be associated with peripheral as well as central ...
openaire   +2 more sources