MRI Radiomics for IDH Genotype Prediction in Glioblastoma Diagnosis [PDF]
Radiomics is a relatively new field which utilises automatically identified features from radiological scans. It has found a widespread application, particularly in oncology because many of the important oncological biomarkers are not visible to the naked eye.
arxiv
Tricarboxylic acid cycle enzyme activities in a mouse model of methylmalonic aciduria [PDF]
Methylmalonic acidemia (MMA) is a propionate pathway disorder caused by dysfunction of the mitochondrial enzyme methylmalonyl-CoA mutase (MMUT). MMUT catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA, an anaplerotic reaction which feeds into ...
Baumgartner, Matthias R+6 more
core +1 more source
Mechanism of reconstitution/activation of the soluble PQQ-dependent glucose dehydrogenase from Acinetobacter calcoaceticus: a comprehensive study [PDF]
The ability to switch on the activity of an enzyme through its spontaneous reconstitution has proven to be a valuable tool in fundamental studies of enzyme structure/reactivity relationships or in the design of artificial signal transduction systems in bioelectronics, synthetic biology, or bioanalytical applications.
arxiv
Purification and properties of the nicotinamide–adenine dinucleotide phosphate-dependent isocitrate dehydrogenase from pig liver cytoplasm [PDF]
John Illingworth, Keith F. Tipton
openalex +1 more source
Outcomes of Isocitrate Dehydrogenase Wild Type Glioblastoma after Re-irradiation
Purpose: Glioblastomas (GBM) are the most common malignant primary brain tumors in adults and have a dismal prognosis. Patients frequently suffer from local tumor recurrences, with limited therapeutic options.
Felix Ehret+8 more
doaj
Nalidixic Acid-Resistant Mutants of Escherichia coli Deficient in Isocitrate Dehydrogenase [PDF]
Robert B. Helling, John S. Kukora
openalex +1 more source
Temperature and enzyme activity in poikilotherms. Isocitrate dehydrogenases in rainbow-trout liver [PDF]
Thomas W. Moon, Peter W. Hochachka
openalex +1 more source
In this study, we first thoroughly assayed the response of the key enzymes of energy metabolism and the antioxidant system in Yarrowia lipolytica yeast at extreme pH.
Tatyana I. Rakhmanova+5 more
doaj +1 more source
A non‐redox role of the coenzyme in the catalysis of isocitrate dehydrogenase [PDF]
Marie F. Carlier+3 more
openalex +1 more source
Language Models and Retrieval Augmented Generation for Automated Structured Data Extraction from Diagnostic Reports [PDF]
Purpose: To develop and evaluate an automated system for extracting structured clinical information from unstructured radiology and pathology reports using open-weights large language models (LMs) and retrieval augmented generation (RAG), and to assess the effects of model configuration variables on extraction performance.
arxiv