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Radiomics for predicting grades, isocitrate dehydrogenase mutation, and oxygen 6-methylguanine-DNA methyltransferase promoter methylation of adult diffuse gliomas: combination of structural MRI, apparent diffusion coefficient, and susceptibility-weighted imaging. [PDF]

Quant Imaging Med Surg
Zhu Z, Shen J, Liang X, Zhou J, Liang J, Ni L, Wang H, Ye M, Chen S, Yang H, Chen Q, Li X, Zhang W, Lu J, Ge D, Fu L, Zhu Y, Zhang X, Sun Y, Zhang B.   +19 more
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Predicting Isocitrate Dehydrogenase (IDH) Mutation Status in Gliomas Using Multiparameter MRI Radiomics Features

Journal of Magnetic Resonance Imaging, 2020
Accurate and noninvasive detection of isocitrate dehydrogenase (IDH, including IDH1 and IDH2) status is clinically meaningful for molecular stratification of glioma, but remains challenging.
Hong Peng, Jiaohua Huo, Bo Li, Yuanyuan Cui, Hao Zhang, Liang Zhang, Lin Ma   +6 more
semanticscholar   +1 more source

Characterisation of isocitrate dehydrogenase 1/isocitrate dehydrogenase 2 gene mutation and the d‐2‐hydroxyglutarate oncometabolite level in dedifferentiated chondrosarcoma

Histopathology, 2020
Dedifferentiated chondrosarcoma (DDCHS) is an aggressive type of chondrosarcoma that results from high‐grade transformation of a low‐grade chondrosarcoma. Mutations in the isocitrate dehydrogenase (IDH) 1 gene and the IDH2 gene that lead to increased d‐2‐
Nissreen Mohammad, D. Wong, A. Lum, Jonah Lin, Julie Ho, Cheng-Han Lee, S. Yip   +6 more
semanticscholar   +1 more source

Isocitrate dehydrogenase 1 mutations in melanoma frequently co‐occur with NRAS mutations

Histopathology, 2018
Isocitrate dehydrogenase 1 (IDH1) is a metabolic enzyme that converts isocitrate to α‐ketoglutarate. IDH1 mutations are associated with the accumulation of the oncometabolite D‐2‐hydroxyglutarate, which acts as an epigenetic modifier, and the development
K. Linos, L. Tafe
semanticscholar   +1 more source

Development of Novel Therapeutics Targeting Isocitrate Dehydrogenase Mutations in Cancer.

Current Topics in Medicinal Chemistry, 2018
Isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that catalyze the conversion of isocitrate to α-ketoglutarate (αKG). IDH1 and IDH2 regulate several cellular processes, including oxidative respiration, glutamine metabolism ...
H. Sharma
semanticscholar   +1 more source

Structural analysis of oncogenic mutation of isocitrate dehydrogenase 1.

Molecular Biosystems, 2016
Arginine to histidine mutation at position 132 (R132H) in isocitrate dehydrogenase 1 (IDH1) led to reduced affinity of the respective enzymes for isocitrate and increased affinity for α-ketoglutarate (AKG) and NADPH.
V. Rajendran
semanticscholar   +1 more source

Imaging prediction of isocitrate dehydrogenase (IDH) mutation in patients with glioma: a systemic review and meta-analysis

European Radiology, 2018
C. Suh, H. Kim, S. Jung, C. Choi, Sang Joon Kim   +4 more
semanticscholar   +1 more source