Results 31 to 40 of about 1,401 (50)

Maffucci syndrome complicated by giant chondrosarcoma in the left ankle with an IDH1 R132C mutation: a case report

World Journal of Surgical Oncology, 2022
Background Maffucci syndrome (MS) is a rare, nonhereditary congenital mesodermal dysplasia characterized by multiple enchondromas and hemangiomas, associated with an increased risk of developing malignant tumors.
Haiyan Lv, Hantao Jiang, Minge Zhang, Huarong Luo, Zhenghua Hong, Hai Yang, Weiming Xu, Bo Shen, Wei Zhang, Hao Qiu, Rangteng Zhu   +10 more
doaj   +1 more source

Expression of multidrug transporter P‐glycoprotein in Pichia pastoris affects the host's methanol metabolism

Microbial Biotechnology, 2019
Summary Pichia pastoris KM71H (MutS) is an efficient producer of hard‐to‐express proteins such as the membrane protein P‐glycoprotein (Pgp), an ATP‐powered efflux pump which is expressed properly, but at very low concentration, using the conventional ...
Wan‐cang Liu, Fei Zhou, Di Xia, Joseph Shiloach   +3 more
doaj   +1 more source

ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer

Molecular & Cellular Oncology, 2018
The oncometabolite, D-2-hydroxyglutarate, accumulates in various cancers because of acquired mutations in isocitrate dehydrogenase 1 & 2. Here, we describe a new mechanism for D-2-hydroxyglutarate accumulation in breast cancer.
Prachi Mishra, Wei Tang, Stefan Ambs
doaj   +1 more source

Comparison of Biochemical Activities between High and Low Lipid-Producing Strains of Mucor circinelloides: An Explanation for the High Oleaginicity of Strain WJ11. [PDF]

PLoS ONE, 2015
The oleaginous fungus, Mucor circinelloides, is one of few fungi that produce high amounts of γ-linolenic acid (GLA); however, it usually only produces
Xin Tang, Haiqin Chen, Yong Q Chen, Wei Chen, Victoriano Garre, Yuanda Song, Colin Ratledge   +6 more
doaj   +1 more source

Impact of IDH1 Mutation on Long-Term Survival in Patients with Diffuse Glioma

Central Asian Journal of Medical Sciences, 2019
Objectives: Diffuse brain gliomas are common primary brain tumor associated with a poor prognosis. In this study, we aimed to determine the impact of IDH1 mutation status on long term survival.
Enkhee Ochirjav, Tuul Baldandorj, Gheeyoung Choe, Bayarmaa Enkhbat   +3 more
doaj   +1 more source

Cognitive functioning in a cohort of high-grade glioma patients

Radiology and Oncology, 2023
High grade gliomas are associated with cognitive problems. The aim of the study was to investigate cognitive functioning in a cohort of patients with high grade glioma, according to isocitrate dehydrogenase (IDH) and methyl guanine methyl transferase ...
Skufca Smrdel Andreja Cirila, Podlesek Anja, Skoblar Vidmar Marija, Markovic Jana, Jereb Jana, Okorn Manja Kuzma, Smrdel Uros   +6 more
doaj   +1 more source

Potent immunosuppressive effects of the oncometabolite R-2-hydroxyglutarate

OncoImmunology, 2018
Somatic gain-of-function mutations in isocitrate dehydrogenase (NADP(+)) 1, cytosolic (IDH1) or isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2) are bona fide oncogenic drivers of acute myeloid leukemia and glioma because the neomorphic enzymes
Lorenzo Galluzzi, Guido Kroemer
doaj   +1 more source

An electrophoretic and cytological study of hybridisation between Aconitum napellus ssp. skerisorae (2n= 32) and A. variegatum (2n= 16). I Electrophoretic evidence

Acta Societatis Botanicorum Poloniae, 2014
The variability of six enzymes in pure and mixed populations of Aconitum napellus and A. variegatum, both from the Tatra Mountains was analysed by means of electrophoresis on starch and polyacrylamide gels. The enzymes differentiating the studied species
Roman Zieliński
doaj   +1 more source

A real-world study of adverse drug reactions of two isocitrate dehydrogenase inhibitor based on the US FDA adverse event reporting system and VigiAccess databases

Frontiers in Pharmacology
Background and objectivesIsocitrate dehydrogenase (IDH) inhibitor drugs (Enasidenib, Ivosidenib) restore normal metabolism and epigenetic regulation in cells, offering a precision-targeted therapeutic option for acute myeloid leukemia (AML) patients with
Mengmeng Peng, Mengmeng Peng, Qian Guo, Zihan Dang, Baiquan Zhang, Manjuan Li, Manjuan Li, Zixuan Wang, Zixuan Wang, Xuemian Lu, Xuemian Lu, Jie Lin   +11 more
doaj   +1 more source

Cytosolic NADP-isocitrate dehydrogenase in Arabidopsis leaves and roots

Biologia Plantarum, 2012
NADP-dependent isocitrate dehydrogenase (NADP-ICDH) catalyses the production of NADPH, which is an essential component in the cellular homeostasis. In Arabidopsis, the kinetic parameters (K m and V max) of cytosolic NADP-ICDH were different in leaves and
M. Leterrier, J. B. Barroso, J. M. Palma, F. J. Corpas   +3 more
doaj   +1 more source