Results 31 to 40 of about 343,303 (317)

The relative isoform expression levels of isocitrate dehydrogenase in breast cancer: IDH2 is a potential target in MDA-MB-231 cells [PDF]

Korean Journal of Clinical Oncology, 2023
Purpose The isocitrate dehydrogenase (IDH) family plays an essential role in metabolism and energy production. The relative expression levels of IDH isoforms (IDH1, IDH2, and IDH3) have prognostic significance in several malignancies, including breast ...
Shuyu Piao, Seonhee Kim, Youngduk Seo, Jinsun Lee, Sunhee Jeon, Giang-Huong Vu, Min-Kyung Yeo, Cuk-Seong Kim   +7 more
doaj   +1 more source

Biochemical elucidation of citrate accumulation in Synechocystis sp. PCC 6803 via kinetic analysis of aconitase

Scientific Reports, 2021
A unicellular cyanobacterium Synechocystis sp. PCC 6803 possesses a unique tricarboxylic acid (TCA) cycle, wherein the intracellular citrate levels are approximately 1.5–10 times higher than the levels of other TCA cycle metabolite.
Maki Nishii, Shoki Ito, Noriaki Katayama, Takashi Osanai   +3 more
doaj   +1 more source

Isocitrate dehydrogenase mutations in leukemia [PDF]

Journal of Clinical Investigation, 2013
Recent genome-wide discovery studies have identified a spectrum of mutations in different malignancies and have led to the elucidation of novel pathways that contribute to oncogenic transformation. The discovery of mutations in the genes encoding isocitrate dehydrogenase (IDH) has uncovered a critical role for altered metabolism in oncogenesis, and the
Anna Sophia McKenney, Ross L. Levine
openaire   +3 more sources

Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue

Experimental and Molecular Medicine, 2020
Isocitrate dehydrogenase 2 (IDH2) is an NADP+-dependent enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate in the mitochondrial matrix, and is critical for the production of NADPH to limit the accumulation of ...
Jae-Ho Lee, Y. Go, Do-Young Kim, S. H. Lee, O. Kim, Y. Jeon, T. Kwon, J. Bae, D. Song, I. Rhyu, I. Lee, M. Shong, Byung-Chul Oh, C. Petucci, Jeen-Woo Park, T. Osborne, S. Im   +16 more
semanticscholar   +1 more source

A comparison of the phosphorylated and unphosphorylated forms of isocitrate dehydrogenase from Escherichia coli ML308 [PDF]

, 1984
NADP+ can protect active isocitrate dehydrogenase against attack by several proteases. Inactive phosphorylated isocitrate dehydrogenase is much less susceptible to proteolysis than the active enzyme, and it is not protected by NADP+.
Bennett, Bergstrom, Cohen, Donita Garland, Fischer, Garnak, Guy, H.G. Nimmo, Huang, Laemmli, Laporte, Laporte, Nimmo, Takeda, Walsh, Wang   +15 more
core   +1 more source

Divergent effects of glutathione depletion on isocitrate dehydrogenase 1 and the pentose phosphate pathway in hamster liver

Physiological Reports, 2020
The liver regenerates NADPH via multiple pathways to maintain redox balance and reductive biosynthesis. The pentose phosphate pathway (PPP) contributes to hepatic lipogenesis by supplying NADPH, and it is thought to play a major role in response to ...
Eunsook S. Jin, Min H. Lee, Craig R. Malloy   +2 more
doaj   +1 more source

Isocitrate Dehydrogenase Genes [PDF]

Deutsches Ärzteblatt international, 2015
The molecular classification and taxonomy of malignant diseases, such as the one successfully applied and published by The Cancer Genome Atlas Project TCGA (http://cancergenome.nih.gov/) for urinary bladder and colorectal cancer, adenocarcinoma of the stomach, and glioblastoma multiforme, provides the opportunity to define so-called driver mutations ...
openaire   +3 more sources

Nondecarboxylating and Decarboxylating Isocitrate Dehydrogenases: Oxalosuccinate Reductase as an Ancestral Form of Isocitrate Dehydrogenase [PDF]

Journal of Bacteriology, 2008
ABSTRACTIsocitrate dehydrogenase (ICDH) fromHydrogenobacter thermophiluscatalyzes the reduction of oxalosuccinate, which corresponds to the second step of the reductive carboxylation of 2-oxoglutarate in the reductive tricarboxylic acid cycle. In this study, the oxidation reaction catalyzed byH. thermophilusICDH was kinetically analyzed. As a result, a
Yasuo Igarashi, Miho Aoshima
openaire   +3 more sources

Research Progress of Isocitrate Dehydrogenase Gene Mutation Therapy

Xiehe Yixue Zazhi, 2023
Isocitrate dehydrogenase (IDH), a key enzyme in the tricarboxylic acid cycle, plays an important role in cellular energy metabolism. When the IDH gene is mutated, the enzyme activity is altered, resulting in an accumulation of a large amount of the tumor
LIN Meijia, ZENG Yeting, WANG Xinrui, HUANG Xiongfei   +3 more
doaj   +1 more source

Studies on carbohydrate metabolism in Bacillus sphaericus 1593 [PDF]

, 2010
Bacillus sphaericus 1593 was found to grow poorly on glucose when provided as sole carbon source. However, growth was significantly much higher when acetate was provided as the carbon source, ascompared to glucose. The activities of aconitase, isocitrate
Chhatpar, HS, Ingle, SS, Panchal, V
core   +2 more sources