Results 51 to 60 of about 347,846 (181)

Radiomics-based machine learning methods for isocitrate dehydrogenase genotype prediction of diffuse gliomas

Journal of Cancer Research and Clinical Oncology, 2019
PurposeReliable and accurate predictive models are necessary to drive the success of radiomics. Our aim was to identify the optimal radiomics-based machine learning method for isocitrate dehydrogenase (IDH) genotype prediction in diffuse gliomas ...
Shuang Wu, Jin Meng, Qi Yu, Ping Li, S. Fu   +4 more
semanticscholar   +1 more source

Impact of IDH Mutations on DNA Methylation of Acute Myeloid Leukemia Related Genes: A Review Article

مجلة كلية الطب
Background: Acute myeloid leukemia is one of the deadliest hematologic malignancies that is marked by genetic alterations, abnormal cellular functions, and proliferation. Mutations in isocitrate dehydrogenase genes, particularly isocitrate dehydrogenase
Duha M. Bayram, Fadhel M. Lafta, Bassam F. Matti   +2 more
doaj   +1 more source

Desmognathus abditus [PDF]

, 2010
Number of Pages: 2Integrative BiologyGeological ...
Tilley, Steven G.
core   +1 more source

Location and type of isocitrate dehydrogenase mutations influence clinical characteristics and disease outcome of acute myeloid leukemia [PDF]

, 2012
Background: Mutations of isocitrate dehydrogenase 1 and 2 are novel common genetic alterations identified in acute myeloid leukemia. Aims: To investigate the frequency, clinical associations and prognostic effect of isocitrate dehydrogenase 1 and 2 ...
Adam, Emma, Andrikovics, Hajnalka, Batai, Arpad, Bors, Andras, Csomor, Judit, Dolgos, Janos, Feczko, Angela, Fekete, Sandor, Karaszi, Eva, Koszarska, Magdalena, Kozma, Andras, Lehoczky, Eniko, Lovas, Nora, Masszi, Tamas, Matrai, Zoltan, Meggyesi, Nóra, Orbán, Tamás I., Reichardt, Judit, Sipos, Andrea, Tordai, Attila   +19 more
core   +1 more source

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages.

Journal of Clinical Investigation, 2019
Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle intermediates citrate, itaconate, and succinate.
David P. De Souza, A. Achuthan, Man Kit Sam Lee, K. Binger, Ming-Chin Lee, Sophia Davidson, D. Tull, M. McConville, A. Cook, A. Murphy, J. Hamilton, A. Fleetwood   +11 more
semanticscholar   +1 more source

Biogenesis of Glyoxysomes [PDF]

, 1980
Biosynthesis of isocitrate lyase, a tetrameric enzyme of the glyoxysomal matrix, was studied in Neurospora crassa, in which the formation of glyoxysomes was induced by a substitution of sucrose medium by acetate medium. * 1.
Neupert, Walter, Zimmermann, Richard
core   +1 more source

Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes

The Scientific World Journal, 2014
Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine ε ...
Martin Krátký, Eva Novotná, Shalini Saxena, Perumal Yogeeswari, Dharmarajan Sriram, Markéta Švarcová, Jarmila Vinšová   +6 more
doaj   +1 more source

Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma. [PDF]

, 2017
Infiltrating low grade gliomas (LGGs) are heterogeneous in their behavior and the strategies used for clinical management are highly variable. A key factor in clinical decision-making is that patients with mutations in the isocitrate dehydrogenase 1 and ...
Berger, Mitchel S, Chang, Susan M, Crane, Jason C, Elkhaled, Adam, Jalbert, Llewellyn E, Kurhanewicz, John, Molinaro, Annette M, Neill, Evan, Nelson, Sarah J, Olson, Marram P, Phillips, Joanna J, Ronen, Sabrina M, Williams, Aurelia   +12 more
core   +1 more source

Characterizing fruit ripening in plantain and Cavendish bananas: A proteomics approach [PDF]

, 2020
The fruit physiology of banana cultivars other than Cavendish is poorly understood. To study the ripening process, samples were taken daily from plantain and Cavendish bananas and the ripening stages were determined. We present data from the green to the
Bhuiyan, F., Campos, N.A., Carpentier, Sebastien C., Swennen, Rony L.   +3 more
core   +1 more source

Metabolome-guided genomics to identify mutations in isocitrate dehydrogenase, fumarate hydratase and succinate dehydrogenase genes in pheochromocytoma and paraganglioma

Genetics in Medicine, 2018
Metabolic aberrations have been described in neoplasms with pathogenic variants (PV) in the Krebs cycle genes encoding succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH).
S. Richter, L. Gieldon, Ying Pang, M. Peitzsch, Thanh T. Huynh, R. Letón, Bruna Viana, T. Ercolino, Anastasios Mangelis, E. Rapizzi, M. Menschikowski, D. Aust, M. Kroiss, F. Beuschlein, V. Gudziol, H. Timmers, J. Lenders, M. Mannelli, A. Cascón, K. Pacak, M. Robledo, G. Eisenhofer, B. Klink   +22 more
semanticscholar   +1 more source