Results 51 to 60 of about 358,941 (349)

Study of Surrogate Immunohistochemical Markers IDH1, ATRX, BRAF V600E, and p53 Mutation in Astrocytic and Oligodendroglial Tumors

Indian Journal of Neurosurgery, 2023
Introduction In consonance with current the World Health Organization (WHO) classification of the central nervous system (CNS) tumors (2016), histological diagnosis of gliomas should be reinforced by molecular information.
Santosh Sharma, Kusum Mathur, Alka Mittal, Meel Mukta, Arpita Jindal, Mukesh Kumar   +5 more
doaj   +1 more source

Frequency and prognostic significance of isocitrate dehydrogenase 1 mutations in cholangiocarcinoma: a systematic literature review.

Journal of Gastrointestinal Oncology, 2019
Background The recognition of distinct molecular subgroups within cholangiocarcinoma (CC), along with the increasing availability of targeted therapies, suggests that further characterization of the prevalence and prognosis of frequently occurring ...
A. Boscoe, C. Rolland, R. Kelley
semanticscholar   +1 more source

Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis [PDF]

, 2005
Introduction: Acute metabolic acidosis of non-renal origin is usually a result of either lactic or ketoacidosis, both of which are associated with a high anion gap.
Forni, L.G., Hilton, P.J., Lord, Gwyn A., McKinnon, W., Peron, J.M.R., Treacher, D.F.   +5 more
core   +2 more sources

Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism

Frontiers in Endocrinology, 2020
Aim: Isocitrate dehydrogenase 1 (IDH1) is key enzyme involved in cellular metabolism and DNA repair. Mutations in IDH1 occur in up to 25% of cholangiocarcinomas.
Li Su, Xinglong Zhang, Lei Zheng, Miaomiao Wang, Zhifa Zhu, Ping Li   +5 more
doaj   +1 more source

Ventajas de la secuenciación de próxima generación sobre la hibridación fluorescente in situ para detectar la codeleción 1p/19q en oligodendrogliomas

Medicina U.P.B., 2023
El perfil molecular de los gliomas permite garantizar la precisión del diagnóstico, informar el pronóstico e identificar opciones de tratamiento.
León Darío Ortiz, David Andrés Galvis, Ronald Guillermo Peláez, Carlos Jaime Yepes, Piedad Matilde Agudelo   +4 more
doaj   +1 more source

Biogenesis of Glyoxysomes [PDF]

, 1980
Biosynthesis of isocitrate lyase, a tetrameric enzyme of the glyoxysomal matrix, was studied in Neurospora crassa, in which the formation of glyoxysomes was induced by a substitution of sucrose medium by acetate medium. * 1.
Neupert, Walter, Zimmermann, Richard
core   +1 more source

FDA Approval Summary: Ivosidenib for Relapsed or Refractory Acute Myeloid Leukemia with an Isocitrate Dehydrogenase-1 Mutation

Clinical Cancer Research, 2019
The FDA approved ivosidenib (Tibsovo; Agios), a small-molecule inhibitor of isocitrate dehydrogenase (IDH)1 on July 20, 2018, for treatment of adults with relapsed or refractory acute myeloid leukemia (R/R AML) with susceptible IDH1 mutation as detected ...
Kelly J. Norsworthy, Lola Luo, Vicky Hsu, R. Gudi, Sarah E Dorff, D. Przepiorka, A. Deisseroth, Y. Shen, Christopher M. Sheth, R. Charlab, G. Williams, Kirsten B. Goldberg, A. Farrell, R. Pazdur   +13 more
semanticscholar   +1 more source

Isocitrate Dehydrogenase Mutations in Glioma: From Basic Discovery to Therapeutics Development

Frontiers in Oncology, 2019
Isocitrate dehydrogenase (IDH) is a key rate-limiting enzyme in the Krebs cycle that plays an important role in energy metabolism. In recent years, it has been found that IDH mutations are closely related to the occurrence and development of glioma, and ...
Juan Huang, Jialong Yu, Lin Tu, Nanqu Huang, Hang Li, Yong Luo   +5 more
semanticscholar   +1 more source

Mutasi Isocitrate Dehydrogenase 1 dan 2 pada Glioma

JBN (Jurnal Bedah Nasional), 2020
Klasifikasi tumor sistem saraf pusat WHO terakhir didasarkan atas histogenesis tumor dan karakteristik molekuler genetik. Perubahan klasifikasi yang paling signifikan terjadi pada tumor glioma difus yang paling signifikan, yaitu katagori tumor secara ...
Ni Putu Sriwidyani
doaj   +1 more source

Implications of Concurrent IDH1 and IDH2 Mutations on Survival in Glioma—A Case Report and Systematic Review

Current Issues in Molecular Biology, 2022
Both IDH1 (isocitrate dehydrogenase 1) and IDH2 (isocitrate dehydrogenase 2) mutations play a vital role in the development of gliomas through disruption of normal cellular metabolic processes.
Alexander Yuile, Laveniya Satgunaseelan, Joe Wei, Marina Kastelan, Michael F. Back, Maggie Lee, Heng Wei, Michael E. Buckland, Adrian Lee, Helen R. Wheeler   +9 more
doaj   +1 more source