Results 61 to 70 of about 358,941 (349)

Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer [PDF]

, 2019
York University ...
Bhattacharya, Debasmita, Scimè, Anthony
core   +1 more source

Molecular and Genetic Determinants of Glioma Cell Invasion. [PDF]

, 2017
A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation.
Kato, Yoichiro, Masui, Kenta, Mischel, Paul S, Sawada, Tatsuo, Shibata, Noriyuki   +4 more
core   +2 more sources

The equilibrium constant of the isocitrate dehydrogenase reaction [PDF]

Biochemical Journal, 1968
1. The equilibrium constant for oxidative decarboxylation of isocitrate by NADP+, catalysed by isocitrate dehydrogenase, was measured in solutions of various ionic strengths and at several temperatures. 2. Thermodynamic values for the reaction were obtained by extrapolation to zero ionic strength, and the heat of reaction was estimated. 3.
J C, Londesborough, K, Dalziel
openaire   +2 more sources

Isoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibition

bioRxiv, 2018
Somatic mutations in cytosolic or mitochondrial isoforms of isocitrate dehydrogenase (IDH1 or IDH2, respectively) contribute to oncogenesis via production of the metabolite 2-hydroxyglutarate (2HG).
James J. Harding, M. Lowery, A. Shih, J. Schvartzman, Shengqi Hou, C. Famulare, Minal A. Patel, M. Roshal, Richard K. Do, A. Zehir, Daoqi You, S. D. Selcuklu, A. Viale, Marty S Tallman, D. Hyman, Ed Reznik, Lydia W. S. Finley, E. Papaemmanuil, A. Tosolini, M. Frattini, Kyle J. MacBeth, Guowen Liu, Bin Fan, S. Choe, Bin Wu, Y. Janjigian, I. Mellinghoff, Luis A. Diaz, Ross L Levine, G. Abou-Alfa, E. Stein, A. Intlekofer   +31 more
semanticscholar   +1 more source

Impact of IDH Mutations on DNA Methylation of Acute Myeloid Leukemia Related Genes: A Review Article

مجلة كلية الطب
Background: Acute myeloid leukemia is one of the deadliest hematologic malignancies that is marked by genetic alterations, abnormal cellular functions, and proliferation. Mutations in isocitrate dehydrogenase genes, particularly isocitrate dehydrogenase
Duha M. Bayram, Fadhel M. Lafta, Bassam F. Matti   +2 more
doaj   +1 more source

Adjunctive perampanel for glioma-associated epilepsy

Epilepsy and Behavior Case Reports, 2018
Glioma-associated epilepsy is associated with excessive glutamate signaling. We hypothesized that perampanel, an amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor antagonist, would treat glioma-related epilepsy.
Anastasie M. Dunn-Pirio, Sarah Woodring, Eric Lipp, James E. Herndon, II, Patrick Healy, Mallika Weant, Dina Randazzo, Annick Desjardins, Henry S. Friedman, Katherine B. Peters   +9 more
doaj   +1 more source

Isocitrate Dehydrogenase 1 and 2 Mutations in Pediatric Neuroblastoma Patients

Medeniyet Medical Journal, 2023
Objective: Neuroblastoma is one of the common tumors of childhood. The demonstration of new factors such as isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations will be important in the diagnosis and treatment.
Emre LEVENTOGLU, Gurses SAHIN, Sule YESIL, Ceyhun BOZKURT, Nazmiye YUKSEK, Ali FETTAH, Sule TOPRAK, Burcak KURUCU BILGIN, Emre CAPKINOGLU, Nilgun EROGLU, Sibel AKPINAR TEKGUNDUZ, Ayse Ulya ERTEM   +11 more
doaj   +1 more source

Pay32p of the Yeast Yarrowia lipolytica Is an Intraperoxisomal Component of the Matrix Protein Translocation Machinery [PDF]

, 1995
Pay mutants of the yeast Yarrowia lipolytica fail to assemble functional peroxisomes. One mutant strain, pay32-1, has abnormally small peroxisomes that are often found in clusters surrounded by membranous material.
Rachubinski, Richard A.,, Szilard, Rachel K.,, Titorenko, Vladimir I.,, Veenhuis, Marten,   +3 more
core   +3 more sources

Differentiation Syndrome Associated With Enasidenib, a Selective Inhibitor of Mutant Isocitrate Dehydrogenase 2: Analysis of a Phase 1/2 Study

JAMA Oncology, 2018
Importance Enasidenib mesylate, a mutant isocitrate dehydrogenase 2 (IDH2) protein inhibitor that promotes differentiation of leukemic myeloblasts, was recently approved by the US Food and Drug Administration for use in relapsed/refractory (R/R) mutant ...
A. Fathi, C. Dinardo, I. Kline, Laurie Kenvin, I. Gupta, E. Attar, E. Stein, S. de Botton   +7 more
semanticscholar   +1 more source

Alterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: A proteomic view [PDF]

, 2006
The proper functioning of mitochondria requires that both the mitochondrial and the nuclear genome are functional. To investigate the importance of the mitochondrial genome, which encodes only 13 subunits of the respiratory complexes, the mitochondrial ...
Abdul, Appleby, Armstrong, Bai, Bourges, Buchet, Chai, Claros, Da Cruz, Dey, Du, Garcia, Gianazza, Joseph, King, King, Lescuyer, Luche, Manjasetty, Martinus, Perkins, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Santoni, Sharma, Sharp, Sherer, Singh, Sinha, Suzuki, Tastet, Taylor, Tryoen-Toth, Ugalde, Wiedemann, Zamzami, Zischka   +39 more
core   +4 more sources