Results 61 to 70 of about 343,303 (317)

Mutasi Isocitrate Dehydrogenase 1 dan 2 pada Glioma

JBN (Jurnal Bedah Nasional), 2020
Klasifikasi tumor sistem saraf pusat WHO terakhir didasarkan atas histogenesis tumor dan karakteristik molekuler genetik. Perubahan klasifikasi yang paling signifikan terjadi pada tumor glioma difus yang paling signifikan, yaitu katagori tumor secara ...
Ni Putu Sriwidyani
doaj   +1 more source

Bioinformatic Scaling of Allosteric Interactions in Biomedical Isozymes [PDF]

, 2015
Allosteric (long-range) interactions can be surprisingly strong in proteins of biomedical interest. Here we use bioinformatic scaling to connect prior results on nonsteroidal anti-inflammatory drugs to promising new drugs that inhibit cancer cell metabolism.
arxiv   +1 more source

Cancer-Associated Isocitrate Dehydrogenase Mutations [PDF]

The Oncologist, 2012
The role of isocitrate dehydrogenase mutations as a therapeutic target for cancer therapy is examined.
Katharine E. Yen, David P. Schenkein
openaire   +3 more sources

Isoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibition

bioRxiv, 2018
Somatic mutations in cytosolic or mitochondrial isoforms of isocitrate dehydrogenase (IDH1 or IDH2, respectively) contribute to oncogenesis via production of the metabolite 2-hydroxyglutarate (2HG).
James J. Harding, M. Lowery, A. Shih, J. Schvartzman, Shengqi Hou, C. Famulare, Minal A. Patel, M. Roshal, Richard K. Do, A. Zehir, Daoqi You, S. D. Selcuklu, A. Viale, Marty S Tallman, D. Hyman, E. Reznik, Lydia W. S. Finley, E. Papaemmanuil, A. Tosolini, M. Frattini, Kyle J. MacBeth, Guowen Liu, Bin Fan, S. Choe, Bin Wu, Y. Janjigian, I. Mellinghoff, Luis A. Diaz, Ross L Levine, G. Abou-Alfa, E. Stein, A. Intlekofer   +31 more
semanticscholar   +1 more source

Implications of Concurrent IDH1 and IDH2 Mutations on Survival in Glioma—A Case Report and Systematic Review

Current Issues in Molecular Biology, 2022
Both IDH1 (isocitrate dehydrogenase 1) and IDH2 (isocitrate dehydrogenase 2) mutations play a vital role in the development of gliomas through disruption of normal cellular metabolic processes.
Alexander Yuile, Laveniya Satgunaseelan, Joe Wei, Marina Kastelan, Michael F. Back, Maggie Lee, Heng Wei, Michael E. Buckland, Adrian Lee, Helen R. Wheeler   +9 more
doaj   +1 more source

Oncometabolites:linking altered metabolism with cancer [PDF]

, 2013
The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer.
Andronesi, Bardella, Brosnan, Dang, Elkhaled, Ishii, Metallo, Ming Yang, Mullen, Mullen, Patrick J. Pollard, Preusser, Shambaugh, Stepinski, Tomoyoshi Soga, Yang   +15 more
core   +1 more source

Impact of IDH Mutations on DNA Methylation of Acute Myeloid Leukemia Related Genes: A Review Article

مجلة كلية الطب
Background: Acute myeloid leukemia is one of the deadliest hematologic malignancies that is marked by genetic alterations, abnormal cellular functions, and proliferation. Mutations in isocitrate dehydrogenase genes, particularly isocitrate dehydrogenase
Duha M. Bayram, Fadhel M. Lafta, Bassam F. Matti   +2 more
doaj   +1 more source

Multi-modal learning for predicting the genotype of glioma [PDF]

arXiv, 2022
The isocitrate dehydrogenase (IDH) gene mutation is an essential biomarker for the diagnosis and prognosis of glioma. It is promising to better predict glioma genotype by integrating focal tumor image and geometric features with brain network features derived from MRI. Convolutions neural networks show reasonable performance in predicting IDH mutation,
arxiv  

A histochemical study of the red and white muscle fibers Part III. Activity of the diphosphopyridine nucleotide diaphorase and triphosphopyridine nucleotide diaphorase in muscle fibers [PDF]

, 1958
From the histochemical study of DPN and TPN diaphorase on the striated muscles of the cats, the following results were obtained. 1. M. gastrocnemius, which belongs to the white muscle by naked eye, consists of three types of muscle fibers distinguished ...
Ogata, Takuro
core   +1 more source

Radiomics-based machine learning methods for isocitrate dehydrogenase genotype prediction of diffuse gliomas

Journal of Cancer Research and Clinical Oncology, 2019
PurposeReliable and accurate predictive models are necessary to drive the success of radiomics. Our aim was to identify the optimal radiomics-based machine learning method for isocitrate dehydrogenase (IDH) genotype prediction in diffuse gliomas ...
Shuang Wu, Jin Meng, Qi Yu, Ping Li, S. Fu   +4 more
semanticscholar   +1 more source