Results 61 to 70 of about 68,056 (282)

Lactylation in cancer biology: Unlocking new avenues for research and therapy

Cancer Communications, EarlyView.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou, Zhenya Hong, Huimin Zen, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han   +6 more
wiley   +1 more source

Improving the flux distributions simulated with genome-scale metabolic models of Saccharomyces cerevisiae [PDF]

, 2016
Genome-scale metabolic models (GEMs) can be used to evaluate genotype-phenotype relationships and their application to microbial strain engineering is increasing in popularity.
Alper, Asadollahi, Avendaño, Baudry, Becker, Blank, Bro, Brochado, Brochado, Burgard, Canelas, Castegna, Choi, Dijken, Duarte, Dubois, Edwards, Feist, Fleck, Fowler, Förster, Garcia-Albornoz, Gombert, Grabowska, Haselbeck, Heavner, Herrgård, Jouhten, Jung, Kim, Kim, Kim, Kingsbury, Kuepfer, Leber, Lewis, Lewis, Machado, Mahadevan, Mannhaupt, Mannhaupt, McNeil, Milne, Minard, Mo, Monschau, Nissen, Nogae, Nookaew, Nookaew, Orth, Osterlund, Otero, Palmieri, Patil, Rocha, Rocha, Satrustegui, Scalcinati, Segrè, Sánchez, Thomas, Xu, Österlund   +63 more
core   +2 more sources

In Vivo Biosynthesis and Direct Incorporation of Non‐Canonical Amino Acids into Proteins

ChemBioChem, Accepted Article.
Autonomous cells are engineered biological systems capable of biosynthesising and directly incorporating non‐canonical amino acids (ncAAs) into proteins. These systems have the potential to extend the applicability of the genetic code to enable large‐scale fermentative production of proteins carrying ncAAs.
Ivana Drienovska, Jan Hendrik Illies, T. Moritz Weber   +2 more
wiley   +1 more source

Hydroponic culturing upregulates sucrose and glutamine metabolism by enhancing their utilization via intermediates of aerobic pathway in wheat [PDF]

, 2016
Two wheat genotypes were grown in hydroponic culture, containing 4 mM KNO3, NH4Cl and NH4NO3. Activities of N metabolizing enzymes, aminotransferases, carbohydrate and TCA cycle enzymes were analyzed along with protein, amino acid, N, sugar content and ...
Asthir, B., Kaur, B.
core   +1 more source

Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes

Cell Biology International, EarlyView.
ABSTRACT Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in proteomic techniques revealed the presence of acetylation in thousands of non‐histone proteins. Here, we conducted extensive meta‐analysis of 48 acetylomes spanning diverse organisms, including archaea ...
Bruno Sousa Bonifácio, Ariely Barbosa Leite, Ana Caroline de Castro Nascimento Sousa, Suellen Rodrigues Maran, Antoniel Augusto Severo Gomes, Elton J. R. Vasconcelos, Nilmar Silvio Moretti   +6 more
wiley   +1 more source

Intermediary metabolism [PDF]

, 2009
Caenorhabditis elegans has orthologs for most of the key enzymes involved in eukaryotic intermediary metabolism, suggesting that the major metabolic pathways are probably present in this species.
Braeckman, Bart, Houthoofd, Koen, Vanfleteren, Jacques   +2 more
core   +2 more sources

SERUM TRANSAMINASES AND ISOCITRIC DEHYDROGENASE IN KWASHIORKOR [PDF]

Journal of Clinical Pathology, 1960
Serum glutamic oxalacetic transaminase (G-OT), glutamic-pyruvic transaminase (G-PT), and isocitric dehydrogenase (ICD) have been estimated in six groups of subjects, namely, normal British adults, normal Nigerian adults, undernourished Nigerian adults and children, Nigerian children with florid protein malnutrition (kwashiorkor), and cases of protein ...
openaire   +3 more sources

Development of Novel Anticancer Pyrazolopyrimidinones Targeting Glioblastoma

ChemMedChem, EarlyView.
Pyrazolo[1,5‐α]pyrimidinone derivatives exhibit selective cytotoxicity towards glioblastoma (GBM) cells over noncancerous cells. Structure–activity relationship studies identifies a lead compound with significant cytotoxicity activity, inducing apoptosis and necrosis in GBM cells, without affecting noncancerous cells. This demonstrates the potential of
Kate Byrne, Natalia Bednarz, Ciara McEvoy, John C. Stephens, James F. Curtin, Gemma K. Kinsella   +5 more
wiley   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

ISOCITRIC DEHYDROGENASE IN GREEN LEAVES [PDF]

New Phytologist, 1951
A considerable amount of work has been done on the identification and isolation of enzyme systems in plants responsible for biological oxidations. Various metal oxidases have been identified, such as polyphenol oxidase in leaves and other tissues (Nelson & Dawson, I 944), ascorbic acid oxidase in many tissues (Tauber, Kleiner & Mischkind, I935; Stone ...
openaire   +2 more sources