Hub gene identification and prognostic model construction for isocitrate dehydrogenase mutation in glioma [PDF]
Translational Oncology, 2021 Our study attempted to identify hub genes related to isocitrate dehydrogenase (IDH) mutation in glioma and develop a prognostic model for IDH-mutant glioma patients.
Yanfei Jia +4 more
doaj +2 more sources
Identification of Isocitrate Dehydrogenase 2 (IDH2) Mutation in Carotid Body Paraganglioma
Frontiers in Endocrinology, 2021 Carotid body paragangliomas (PGLs) are rare neuroendocrine tumors that develop within the adventitia of the medial aspect of the carotid bifurcation. Carotid body PGLs comprise about 65% of head and neck paragangliomas, however, their genetic background ...
Chunzhang Yang, Abhishek Jha
exaly +3 more sources
Isocitrate dehydrogenase 1 mutation subtypes at site 132 and their translational potential in glioma
CNS Oncology, 2018 In recent years, de novo missense structural mutations in the IDH1 gene of arginine at site 132 (R132) have become a standard for diagnostication and prognostication in glioma management.
Victor M Lu
exaly +3 more sources
Phenotype augmentation using generative AI for isocitrate dehydrogenase mutation prediction in glioma [PDF]
Scientific ReportsThis study investigated the effects of feature augmentation, which uses generated images with specific imaging features, on the performance of isocitrate dehydrogenase (IDH) mutation prediction models in gliomas.
Ha Kyung Jung +6 more
doaj +2 more sources
Screening of Methylation Signature and Gene Functions Associated With the Subtypes of Isocitrate Dehydrogenase-Mutation Gliomas [PDF]
Frontiers in Bioengineering and Biotechnology, 2019 Isocitrate dehydrogenase (IDH) is an oncogene, and the expression of a mutated IDH promotes cell proliferation and inhibits cell differentiation. IDH exists in three different isoforms, whose mutation can cause many solid tumors, especially gliomas in ...
XiaoYong Pan +11 more
doaj +2 more sources
RNA editing-based classification of diffuse gliomas: predicting isocitrate dehydrogenase mutation and chromosome 1p/19q codeletion [PDF]
BMC Bioinformatics, 2019 Background Accurate classification of diffuse gliomas, the most common tumors of the central nervous system in adults, is important for appropriate treatment.
Sean Chun-Chang Chen +3 more
doaj +2 more sources
Research Progress of Isocitrate Dehydrogenase Gene Mutation Therapy
Xiehe Yixue Zazhi, 2023 Isocitrate dehydrogenase (IDH), a key enzyme in the tricarboxylic acid cycle, plays an important role in cellular energy metabolism. When the IDH gene is mutated, the enzyme activity is altered, resulting in an accumulation of a large amount of the tumor
LIN Meijia +3 more
doaj +1 more source
Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas. [PDF]
PLoS ONE, 2015 Isocitrate dehydrogenase 1 gene mutations are found in most World Health Organization grade II and III gliomas and secondary glioblastomas. Isocitrate dehydrogenase 1 mutations are known to have prognostic value in high-grade gliomas.
Ming-Yang Li +8 more
doaj +1 more source
Isocitrate Dehydrogenase 1 and 2 Mutations in Pediatric Neuroblastoma Patients
Medeniyet Medical Journal, 2023 Objective: Neuroblastoma is one of the common tumors of childhood. The demonstration of new factors such as isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations will be important in the diagnosis and treatment.
Emre LEVENTOGLU +11 more
doaj +1 more source
IDH1 R132C and ERC2 L309I Mutations Contribute to the Development of Maffucci’s Syndrome
Frontiers in Endocrinology, 2021 BackgroundMaffucci’s syndrome is characterized by the coexistence of multiple enchondromas and soft-tissue hemangiomas. It has been clear that somatic mosaic isocitrate dehydrogenase type 1 (IDH1) or isocitrate dehydrogenase type 2 (IDH2) mutations are ...
Peng Cheng +5 more
doaj +1 more source