Results 11 to 20 of about 693,247 (202)

Accurate prediction of isocitrate dehydrogenase -mutation status of gliomas using SLOW-editing magnetic resonance spectroscopic imaging at 7 T MR. [PDF]

Neurooncol Adv, 2023
BACKGROUND 2-hydroxy-glutarate (2HG) is a metabolite that accumulates in isocitrate dehydrogenase (IDH)-mutated gliomas and can be detected noninvasively using MR spectroscopy.
Weng G, Ermiş E, Maragkou T, Krcek R, Reinhardt P, Zubak I, Schucht P, Wiest R, Slotboom J, Radojewski P.   +9 more
europepmc   +3 more sources

Isocitrate dehydrogenase 1 mutation is associated with reduced levels of inflammation in glioma patients

Cancer Management and Research, 2019
Raushan Auezova,1 Natalia Ivanova,2 Serik Akshulakov,1 Berik Zhetpisbaev,1 Aizhan Kozhakhmetova,1 Nurzhan Ryskeldiyev,1 Khalit Mustafin,1 Daniyar Teltayev,1 Lizette Auezova31Department of Pathology of the Central Nervous System, National Center for ...
Auezova R, Ivanova N, Akshulakov S, Zhetpisbaev B, Kozhakhmetova A, Ryskeldiyev N, Mustafin K, Teltayev D, Auezova L   +8 more
doaj   +1 more source

Studying the Phosphorylation of Isocitrate Dehydrogenase in Humans [PDF]

, 2023
Isocitrate dehydrogenase is an important enzyme in the citric acid cycle where it catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate.
Smith, Hannah
core   +4 more sources

Studies of Isocitrate Dehydrogenase From Bacillus caldotenax [PDF]

, 1992
Most micro-organisms contain an NADP-dependent isocitrate dehydrogenase (ICDH) activity. During growth of micro-organisms on acetate as the sole carbon source the two enzymes of the glyoxylate bypass, isocitrate lyase (ICL) and malate synthase (MS), are ...
Wild, Catherine Margaret
core   +7 more sources

Biological Roles and Therapeutic Applications of IDH2 Mutations in Human Cancer

Frontiers in Oncology, 2021
Isocitrate dehydrogenase (IDH) is a key metabolic enzyme catalyzing the interconversion of isocitrate to α-ketoglutarate (α-KG). Mutations in IDH lead to loss of normal enzymatic activity and gain of neomorphic activity that irreversibly converts α-KG to
Jinxiu Guo, Jinxiu Guo, Ruyue Zhang, Ruyue Zhang, Zhe Yang, Zhe Yang, Zhenfeng Duan, Zhenfeng Duan, Detao Yin, Yubing Zhou, Yubing Zhou   +10 more
doaj   +1 more source

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism

Frontiers in Endocrinology, 2020
Aim: Isocitrate dehydrogenase 1 (IDH1) is key enzyme involved in cellular metabolism and DNA repair. Mutations in IDH1 occur in up to 25% of cholangiocarcinomas.
Li Su, Xinglong Zhang, Lei Zheng, Miaomiao Wang, Zhifa Zhu, Ping Li   +5 more
doaj   +1 more source

IDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway, but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced. [PDF]

PLoS ONE, 2017
Mutations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) gene were recently discovered in vast majority of World Health Organization (WHO) grade II/III gliomas.
Huixia Zhu, Ye Zhang, Jianfeng Chen, Jiangdong Qiu, Keting Huang, Mindan Wu, Chunlin Xia   +6 more
doaj   +1 more source

Clinical significance and research progress of DNA methylation in glioma

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
Glioma has a specific CpG island methylator phenotype (G⁃CIMP), which is closely related to isocitrate dehydrogenase (IDH) mutation. A hypermutation is present at recurrence in temozolomide⁃treated gliomas, and O6⁃methylguanine⁃DNA methyltransferase ...
YAO Ying⁃ying, WANG Lei⁃ming, TENG Liang⁃hong   +2 more
doaj   +1 more source