Results 31 to 40 of about 693,247 (202)

A Nomogram Modeling 11C-MET PET/CT and Clinical Features in Glioma Helps Predict IDH Mutation

Frontiers in Oncology, 2020
Purpose: We developed a 11C-Methionine positron emission tomography/computed tomography (11C-MET PET/CT)-based nomogram model that uses easy-accessible imaging and clinical features to achieve reliable non-invasive isocitrate dehydrogenase (IDH)-mutant ...
Weiyan Zhou, Zhirui Zhou, Jianbo Wen, Fang Xie, Yuhua Zhu, Zhengwei Zhang, Jianfei Xiao, Yijing Chen, Ming Li, Yihui Guan, Tao Hua   +10 more
doaj   +1 more source

Concurrent IDH1 and IDH2 mutations in glioblastoma: A case report

Frontiers in Oncology, 2023
Isocitrate dehydrogenase (IDH) mutations are cornerstone diagnostic features in glioma classification. IDH mutations are typically characterized by mutually exclusive amino acid substitutions in the genes encoding for the IDH1 and the IDH2 enzyme ...
Ali S. Haider, Chibawanye I. Ene, Paolo Palmisciano, Maryam Haider, Ganesh Rao, Leomar Y. Ballester, Gregory N. Fuller   +6 more
doaj   +1 more source

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]

, 2011
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Sylke Müller, Aparicio, I., Eva-Maria Patzewitz, Perner Jan, Isabela Aparicio, Patzewitz, E.-M., Llinas, M., Storm, J., Llinas Manuel, Engel Paul C, Olszewski Kellen, Janet Storm, Perner, J., Storm Janet, Paul C Engel, Kellen Olszewski, Engel, P.C., Manuel Llinas, Olszewski, K., Muller, S., Müller Sylke, Aparicio Isabela, Patzewitz Eva-Maria, Jan Perner   +23 more
core   +1 more source

Research Progress and Prospects of Isocitrate Dehydrogenase Gene Mutation in Chondrosarcoma [PDF]

Zhongguo quanke yixue
Isocitrate dehydrogenase (IDH) is the more mutation-prone human metabolic gene. In the presence of nicotinamide adenine dinucleotide phosphate (NADPH), mutant IDH can bind to α-ketoglutaric acid (α-KG) and reduce it to 2-hydroxyglutaric ...
ZHAO Jingjing, ZHANG Zhihong, ZHEN Junping
doaj   +1 more source

Radiomics-based models to predict IDH mutation status and prognosis in gliomas using MRI: a multicenter study

Frontiers in Oncology
IntroductionGliomas are infiltrative primary intracranial tumors with marked biological and clinical heterogeneity. Prognosis varies widely and depends on tumor grade, histopathological characteristics, and molecular alterations. Isocitrate dehydrogenase
Esra Sümer-Arpak, Esra Sümer-Arpak, Ayca Ersen Danyeli, Ayca Ersen Danyeli, M. Cengiz Yakicier, M. Necmettin Pamir, M. Necmettin Pamir, Koray Özduman, Koray Özduman, Alp Dinçer, Alp Dinçer, Esin Ozturk-Isik, Esin Ozturk-Isik   +12 more
doaj   +1 more source

Cytosolic NADP-isocitrate dehydrogenase in Arabidopsis leaves and roots

, 2012
NADP-dependent isocitrate dehydrogenase (NADP-ICDH) catalyses the production of NADPH, which is an essential component in the cellular homeostasis. In Arabidopsis, the kinetic parameters (K m and V max) of cytosolic NADP-ICDH were different in leaves and
F. J. Corpas, M. Leterrier, J. M. Palma, J. B. Barroso   +3 more
core   +1 more source

Ivosidenib – Another feather in the hat of treatment for acute myeloid leukemia

Indian Journal of Medical and Paediatric Oncology, 2020
The treatment of acute myeloid leukemia has undergone a paradigm shift in the past few years. Multiple new targeted and nontargeted agents have been approved in the recent past.
Jayachandran Perumal Kalaiyarasi
doaj   +1 more source

Rapid detection of isocitrate dehydrogenase 1 mutation status in glioma based on Crispr-Cas12a

Scientific Reports, 2023
The aim is to use Crispr-Cas12a for the rapid detection of the single nucleotide polymorphism (SNP) of isocitrate dehydrogenase 1 (IDH1)-R132H locus and explore the effectiveness and consistency of this method with direct sequencing method for detecting ...
Zhebin Feng, Dongsheng Kong, Wei Jin, Kunyu He, Junyan Zhao, Bin Liu, Hanyun Xu, Xin’guang Yu, Shiyu Feng   +8 more
doaj   +1 more source

The regulatory properties of isocitrate dehydrogenase kinase and isocitrate dehydrogenase phosphatase from Escherichia coli ML308 and the roles of these activities in the control of isocitrate dehydrogenase

, 1984
1. Isocitrate dehydrogenase kinase can use ATP but not other nucleoside triphosphates as a phosphate donor. It responds hyperbolically to both ATP and isocitrate dehydrogenase. 2.
Nimmo, Gillian A., Nimmo, Hugh G.
core   +1 more source

idh-1 neomorphic mutation confers sensitivity to vitamin B12 in Caenorhabditis elegans

Life Science Alliance
Replicating human cancer-associated variant of isocitrate dehydrogenase in C. elegans causes embryonic lethality upon vitamin B12 supplementation due to increased dependency on one-carbon metabolism.
Olga Ponomarova, Alyxandra N Starbard, Alexandra Belfi, Amanda V Anderson, Meera V Sundaram, Albertha JM Walhout   +5 more
doaj   +1 more source