Results 21 to 30 of about 693,247 (202)

Investigating isocitrate dehydrogenase mutations in cancer using new metabolomics methods [PDF]

, 2020
Altered cellular metabolism, as a result of oncogenic mutations, has been observed in a range of cancer types. A detailed understanding of how cancers modify cellular metabolism, which includes changes to the genome, proteome and metabolome, is therefore
Walsby-Tickle, John
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Single arginine mutation in two yeast isocitrate dehydrogenases: biochemical characterization and functional implication. [PDF]

PLoS ONE, 2014
Isocitrate dehydrogenase (IDH), a housekeeping gene, has drawn the attention of cancer experts. Mutation of the catalytic Arg132 residue of human IDH1 (HcIDH) eliminates the enzyme's wild-type isocitrate oxidation activity, but confer the mutant an ...
Ping Song, Huanhuan Wei, Zhengyu Cao, Peng Wang, Guoping Zhu   +4 more
doaj   +1 more source

Malignant Transformation of a Rosette-Forming Glioneuronal Tumor with IDH1 Mutation: A Case Report and Literature Review

World Neurosurgery: X, 2019
Background: Rosette-forming glioneuronal tumor (World Health Organization grade I) is considered as a benign tumor with very low potential for progression.
Ronie Romelean Jayapalan, Kein Seong Mun, Kum Thong Wong, Sheau Fung Sia   +3 more
doaj   +1 more source

Succinate dehydrogenase (SDH)-deficient renal carcinoma:a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients [PDF]

, 2014
Succinate dehydrogenase (SDH)-deficient renal carcinoma has been accepted as a provisional entity in the 2013 International Society of Urological Pathology Vancouver Classification.
Sedivcová, Monika, Yu, Darryl, Papathomas, Thomas, Niemeijer, Nicolasine D., Przybycin, Christopher, Nicoll, Katherine D, Paik, Julie, Miettinen, Markku, Yong, Jim L., Kedziora, Andrew, Andresen, Per Arne, Hes, Ondrej, Toon, Christopher W., Robinson, Bruce G, Corssmit, Eleonora P M, Michal, Michal, Chou, Angela, Hills, Kirsten, Nicoll, Katherine D., Clarkson, Adele, Clifton-bligh, Roderick J., Yong, Jim L, Maclean, Fiona, Yilmaz, Asli, Vlatkovic, Ljiljana, Niemeijer, Nicolasine D, Hartmann, Arndt, Sibony, Mathilde, Agaimy, Abbas, McKenney, Jesse K, Robinson, Bruce G., Van Leenders, Geert J.l.h., Chow, Chung W., Sioson, Loretta, Mckenney, Jesse K., Corssmit, Eleonora P.m., Tan, Puay Hoon, van Leenders, Geert J L H, Yakirevich, Evgeny, Trpkov, Kiril, Benn, Diana E., Gill, Anthony J., Chow, Chung W, Watson, Nicole, Fleming, Stewart, Magi-Galluzzi, Cristina, Clifton-Bligh, Roderick J   +46 more
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Characteristics of the isocitrate dehydrogenase gene and telomerase reverse transcriptase promoter mutations in gliomas in Chinese patients

Brain and Behavior, 2020
Objectives To explore the characteristics of IDH and TERT promoter mutations in gliomas in Chinese patients. Methods A total of 124 Chinese patients with gliomas were enrolled to study the frequencies of mutations in isocitrate dehydrogenase (IDH) and ...
Chong‐Xiao Qu, Hong‐Ming Ji, Xiang‐Cheng Shi, Hong Bi, Li‐Qin Zhai, De‐Wu Han   +5 more
doaj   +1 more source

The diagnostic value of lower glucose consumption for IDH1 mutated gliomas on FDG-PET

BMC Cancer, 2021
Background Non-invasive diagnosis of IDH1 mutation for gliomas has great clinical significance, and PET has natural advantage to detect metabolism, as IDH mutated gliomas share lower glucose consumption. Methods Clinical data of patients with gliomas and
Feng-Min Liu, Yu-fei Gao, Yanyan Kong, Yihui Guan, Jinsen Zhang, Shuai-Hong Li, Dan Ye, Wenyu Wen, Chuantao Zuo, Wei Hua   +9 more
doaj   +1 more source

The role of isocitrate in control of the phosphorylation of isocitrate dehydrogenase in Escherichia coli ML308 [PDF]

, 1985
Isocitrate dehydrogenase from Escherichia coli is regulated by a reversible phosphorylation mechanism. We confirm here that this permits intracellular isocitrate to rise to a level that can sustain growth on acetate.
El-Mansi, E.M.T., E.M.T. El-Mansi, W.H. Holms, Holms, W.H., Nimmo, H.G., H.G. Nimmo   +5 more
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A Simple Panel of IDH1 and P53 in Differential Diagnosis Between Low-Grade Astrocytoma and Reactive Gliosis

Clinical Pathology, 2021
Background: Reactive gliosis is a response of glial tissue to different types of injury such as brain abscess, trauma, hemorrhage, or even neoplastic process.
Bita Geramizadeh, Mahsa Kohandel-Shirazi, Ahmad Soltani   +2 more
doaj   +1 more source

The isocitrate dehydrogenase from cyanobacteria

, 2022
S.73-79The present communication describes the properties of isocitrate dehydrogenase in crude extracts from the unicellular Anacystis nidulans and from heterocysts and vegetative cells of Nostoc muscorum and Anabaena cylindrica.
Refaian, M., Neuer, G., Papen, H., Bothe, H.   +3 more
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Serum isocitrate dehydrogenase activity in Reye's syndrome [PDF]

, 1987
Serum levels of isocitrate dehydrogenase was determined in 12 Reye's syndrome patients and the enzyme levels were compared with serum ornithine carbamyl phosphate, glutamic oxaloacetic transaminase (aspartate aminotransferase), ammonia, and the stages of
Deshmukh, Devendra R., Sarnaik, Ashok P., Shope, Thomas C.   +2 more
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