Results 91 to 100 of about 294 (201)

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma. [PDF]

Antioxid Redox Signal, 2023
Murnan KM, Horbinski C, Stegh AH.
europepmc   +1 more source

Olutasidenib Alone or in Combination With Azacitidine as a Bridge to Transplant in Relapsed/Refractory mIDH1 AML

European Journal of Haematology, EarlyView.
Shira N. Dinner, Justin M. Watts, Jorge E. Cortes, Jay Yang, Maria R. Baer, Gail J. Roboz, Karen W. L. Yee, Antonio Curti, David C. Taussig, Jürgen Krauter, Thomas Prebet, Hua Tian, Aaron D. Sheppard, Pierre Peterlin, Carolyn Grove, Christian Récher, Stéphane de Botton   +16 more
wiley   +1 more source

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia. [PDF]

Nat Commun, 2021
Goldfarb AN, Freeman KC, Sahu RK, Elagib KE, Holy M, Arneja A, Polanowska-Grabowska R, Gru AA, White Z, Khalil S, Kerins MJ, Ooi A, Leitinger N, Luckey CJ, Delehanty LL.   +14 more
europepmc   +1 more source

Utilization of apple pomace as a novel substrate for citric acid production by Yarrowia lipolytica. [PDF]

Sci Rep
Kaban G, Gürakar B, Sayın B, Polat Z, Kaya M.   +4 more
europepmc   +1 more source

Biochemical Characterization and Crystal Structure of a Novel NAD⁺-Dependent Isocitrate Dehydrogenase from Phaeodactylum tricornutum. [PDF]

Int J Mol Sci, 2020
Huang SP, Zhou LC, Wen B, Wang P, Zhu GP.   +4 more
europepmc   +1 more source

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2629-2642, October 2026.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2713-2728, October 2026.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Distribution and Functional Analysis of Isocitrate Dehydrogenases across Kinetoplastids. [PDF]

Genome Biol Evol
Chmelová Ľ, Záhonová K, Albanaz ATS, Hrebenyk L, Horváth A, Yurchenko V, Škodová-Sveráková I.   +6 more
europepmc   +1 more source