Results 111 to 120 of about 294 (201)

Conventional MRI radiomics in patients with suspected early- or pseudo-progression. [PDF]

Neurooncol Adv, 2019
Bani-Sadr A, Eker OF, Berner LP, Ameli R, Hermier M, Barritault M, Meyronet D, Guyotat J, Jouanneau E, Honnorat J, Ducray F, Berthezene Y.   +11 more
europepmc   +1 more source

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, Volume 13, Issue 52, 18 September 2026.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

Advanced Science, Volume 13, Issue 53, 24 September 2026.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai, Zehui Lv, Chen Zhang, Xingdong Yang, Ruoying Wang, Yixin Bian, Jiawei Xu, Han Wang, Yingjie Wang, Long Bai, Jiacan Su, Xisheng Weng   +11 more
wiley   +1 more source

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity. [PDF]

Biochem J, 2020
Luna LA, Lesecq Z, White KA, Hoang A, Scott DA, Zagnitko O, Bobkov AA, Barber DL, Schiffer JM, Isom DG, Sohl CD.   +10 more
europepmc   +1 more source

Natural Compounds Targeting Oncogenic Signaling Networks in Glioblastoma: Molecular Mechanisms, Translational Advances, and Clinical Perspectives

Brain and Behavior, Volume 16, Issue 9, September 2026.
Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, driven by abnormal signaling pathways that promote growth and resistance to treatment. Conventional therapies are inadequate, highlighting the need for novel multitargeted approaches.
Mehrukh Zehravi, Md Abul Hassan, Md. Al Amin, Sherouk Hussein Sweilam, Jeetendra Kumar Gupta, Ramenani Hari Babu, Pericharla Venkata Narasimha Raju, Krishna Vamsi Kandimalla, Phanindra Erukulla, Patibandla Jahnavi, Rajeshwar Vodeti, Abdul Ajeed Mohathasim Billah, Safia Obaidur Rab, Sharuk L. Khan   +13 more
wiley   +1 more source

Highlighting mass spectrometric fragmentation differences and similarities between hydroxycinnamoyl-quinic acids and hydroxycinnamoyl-isocitric acids. [PDF]

Chem Cent J, 2017
Masike K, Mhlongo MI, Mudau SP, Nobela O, Ncube EN, Tugizimana F, George MJ, Madala NE.   +7 more
europepmc   +1 more source

POFUT1 Serves as an Independent Prognostic Factor and Therapeutic Target by Activating the PI3K/AKT Pathway in Glioma

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Objective Protein O‐fucosyltransferase 1 (POFUT1) has been implicated in several malignancies, but its functional and prognostic significance in glioma remains insufficiently defined. This study evaluated whether POFUT1 expression is associated with glioma progression, patient outcome, and PI3K/AKT pathway activity.
Kai Yang, Chunlei Ju, Yifan Wang, Aijie Guo, Xiaochen Yang, Yang Mi, Yifei Su, Chunhong Wang, Hongming Ji   +8 more
wiley   +1 more source

Study of Adaptive Radiotherapy for High‐Grade Glioma Based on Interfraction MRI

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background Currently, there is no clear guidance on the appropriate population or timing for adaptive radiotherapy (ART) in high‐grade glioma (HGG) patients. This study aims to provide individualized ART for HGG patients. Methods Participants received standard “radiotherapy combined with temozolomide” and underwent MRI before radiotherapy (FX0)
Shuangshuang He, Hang Yu, Yuan Yang, Qing Mao, Xiang Wang, Yunhui Zeng, Feng Wang, Mengyuan Liu, Yuantai Li, Kun Gao, Xingchen Peng, Yanhui Liu, Ping Ai   +12 more
wiley   +1 more source