Results 141 to 150 of about 294 (201)

Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis. [PDF]

Proc Natl Acad Sci U S A, 2017
Pham TV, Murkin AS, Moynihan MM, Harris L, Tyler PC, Shetty N, Sacchettini JC, Huang HL, Meek TD.   +8 more
europepmc   +1 more source

Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao, Honghua Zhang, Jingyu Chen, Ziyu Qian, Ning Zhang, Yihua Zhang, Hui Ye, Jianbing Wu, Zhangjian Huang   +8 more
wiley   +1 more source

Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis. [PDF]

Mol Psychiatry, 2016
Yoshimi N, Futamura T, Bergen SE, Iwayama Y, Ishima T, Sellgren C, Ekman CJ, Jakobsson J, Pålsson E, Kakumoto K, Ohgi Y, Yoshikawa T, Landén M, Hashimoto K.   +13 more
europepmc   +1 more source

MRI‐based radiomics model for predicting VEGFA expression and prognosis in lower‐grade glioma

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Background Gliomas are the most common primary tumors of the central nervous system. Their treatment remains highly challenging, with high rates of associated disability and mortality. Conventional prognostic indicators no longer adequately satisfy the clinical demands of precision medicine.
Kun Zhao, Xinyu Hong, Hongrong Cheng, Shoucheng Xu, Dongliang Zhao, Jianyang Lin, Yongbing Gu, Guoqiang Ren, Baomin Chen, Liping Zhan, Yuanwei Wang   +10 more
wiley   +1 more source

NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells. [PDF]

Sci Rep, 2014
Yamada S, Kotake Y, Demizu Y, Kurihara M, Sekino Y, Kanda Y.   +5 more
europepmc   +1 more source

Transverse Relaxation Time Constant of Cystathionine in Human Glioma at 3 T

Magnetic Resonance in Medicine, Volume 96, Issue 3, Page 1076-1082, September 2026.
ABSTRACT Purpose Cystathionine (Cth) has emerged as a promising biomarker for identifying 1p/19q codeleted gliomas. However, little is known about the T2 relaxation time constant of Cth in gliomas. The aim of this study was to measure the T2 of Cth in vivo in glioma and compare it to the T2s of other metabolites at 3 T.
Dinesh K. Deelchand, Francesca Branzoli, Jamie D. Walls, Lucia Nichelli, Marc Sanson, Bertrand Mathon, Małgorzata Marjańska   +6 more
wiley   +1 more source

Solvent isotope-induced equilibrium perturbation for isocitrate lyase. [PDF]

Biochemistry, 2013
Quartararo CE, Hadi T, Cahill SM, Blanchard JS.   +3 more
europepmc   +1 more source

Diagnostic Accuracy of APTw and NOEw MRI Metrics for IDH Mutation and 1p/19q Codeletion Prediction in Gliomas

NMR in Biomedicine, Volume 39, Issue 9, September 2026.
We evaluated how confounding effects from fluid, macromolecules and T1 relaxation impact the performance of APTw and NOEw metrics for noninvasive glioma classification at 3 T. Corrected APTw metrics showed the highest discriminations of IDH‐mutant from wild‐type gliomas (AUC = 0.94–0.96), whereas NOEw metrics did not differ between groups.
Capucine Cadin, Stefano Casagranda, François Xavier Lejeune, Marianne Golse, Bertrand Mathon, Ottavia Dipasquale, Christos Papageorgakis, Mauro Zucchelli, Emmanuel Mandonnet, Stéphane Lehéricy, Franck Bielle, Marc Sanson, Patrick Liebig, Moritz Zaiss, Lucia Nichelli, Francesca Branzoli   +15 more
wiley   +1 more source

Single arginine mutation in two yeast isocitrate dehydrogenases: biochemical characterization and functional implication. [PDF]

PLoS One, 2014
Song P, Wei H, Cao Z, Wang P, Zhu G.
europepmc   +1 more source

Rapid Screening of Bacterial Chemoeffectors of Pseudomonas parafulva Using a CheA ATPase Activity‐Based Assay

Environmental Microbiology, Volume 28, Issue 9, September 2026.
We present a scalable, cell‐free, and straightforward NADH‐coupled CheA ATPase assay for quickly screening potential bacterial chemoeffectors and integrate it into a pipeline to identify both the chemoeffectors and their corresponding chemoreceptors in Pseudomonas parafulva, enabling systematic exploration of chemotactic sensing.
Rui Cui, Jie Li, Ni‐Ye You, Tino Krell, De‐Feng Li   +4 more
wiley   +1 more source