Results 161 to 170 of about 294 (201)
AHA1 Regulates Aβ Production via Modulation of APP Abundance and γ‐Secretase Assembly
Journal of Neurochemistry, Volume 170, Issue 9, September 2026.AHA1 regulates Aβ production through dual mechanisms. AHA1 promotes APP abundance through mechanisms that are at least partially independent of Hsp90 interaction, while cooperating with Hsp90 to regulate APH1/NCT pre‐complex formation, γ‐secretase assembly, and γ‐secretase activity. These coordinated mechanisms contribute to increased Aβ generation and
Arshad Ali Noorani +9 more
wiley +1 more source
Pitfalls in 2HG Detection With TE‐Optimized MRS at 3T
Journal of Neuroimaging, Volume 36, Issue 5, September/October 2026.ABSTRACT Background and Purpose In vivo MRS of 2‐hydroxyglutarate (2HG) may provide diagnostic and monitoring biomarkers in isocitrate dehydrogenase (IDH)‐mutated glioma. A previous meta‐analysis has shown good diagnostic accuracy of TE‐optimized PRESS for IDH‐mutated glioma, but most studies feature IDH‐wildtype glioma as a comparison.
Seyma Alcicek +13 more
wiley +1 more source
Integrative simulation analysis of myocardial ischaemia–reperfusion injury
The Journal of Physiology, Volume 604, Issue 18, Page 7640-7662, 15 September 2026.Abstract figure legend A comprehensive mathematical model of ventricular myocyte was developed to gain insights into the mechanisms underlying cardiac ischaemia–reperfusion injury. The model integrates excitation–contraction (E–C) coupling, cytosolic and mitochondrial pH regulation, pH dependence of major E–C coupling components and cellular energy ...
Takao Shimayoshi +2 more
wiley +1 more source
Assessing the therapeutic potential of PDE‐5 inhibitors in adults: Insights from a multi‐omics study
Physiological Reports, Volume 14, Issue 18, September 2026.Abstract Phosphodiesterase‐5 inhibitors have beneficial pleiotropic effects and hold promise as adjuvant treatments for cancer, dementia, and other disorders. Sixteen men and women aged 50–60 were administered daily sildenafil/tadalafil for 1 month. We characterized molecular signatures of sildenafil/tadalafil treatment via analyses and multi‐omics ...
Kristen A. McGovern +14 more
wiley +1 more source
Isocitrate dehydrogenase of soybeans.
Indian journal of biochemistry & biophysics, 1975 R C, Gupta, R, Narayan
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Iron control of erythroid development by a novel aconitase-associated regulatory pathway.
Blood, 2010 Bullock GC +9 more
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Isocitric Lyase and Isocitric Dehydrogenase in Germinating Lettuce
Physiologia Plantarum, 1968AbstractA soluble isocitric lyase is shown to occur in lettuce seeds. Its activity increases during germination till 72 hours and then falls again. No particulate lyase could be detected. In addition both a soluble and a particulate isocitric dehydrogenase is present in the seeds. Both enzymes react with NAD as well as with NADP.
A. M. Mayer +2 more
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The estimation of d-isocitric acid in urine using isocitrate dehydrogenase
Clinica Chimica Acta, 1978The amount of D-isocitric acid in urine has been estimated using the enzyme isocitrate dehydrogenase. The technique is rapid and easy to perform. Reproducibility of results was good and results from recovery experiments were excellent. The concentration range for early morning urine samples from normal adults was 0.08-0.65 mmol/l with a mean of 0.29 ...
D J, Sutor, J M, Percival
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Mitochondrial Isocitrate Dehydrogenase and Isocitrate Oxidation of Rat Ventral Prostate
Enzyme, 2017Mitochondrial preparations isolated from rat ventral prostate were capable of oxidizing isocitrate by way of NADP isocitrate dehydrogenase (NADP-IDH) and NADIDH. NAD-IDH activity required ADP for activation. The pH responses for NAD-IDH and NADP-IDH were quite different.
L C, Costello, R, Franklin, R, Stacey
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