Results 91 to 100 of about 89,874 (292)

Evaluation of the Drug–Drug Interaction Potential of the GlyT1 Inhibitor Iclepertin (BI 425809): A Physiologically Based Pharmacokinetic (PBPK) Modeling Approach

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Despite predicting poor functional outcomes and being a significant patient burden, there are no approved pharmacotherapies to treat symptoms of cognitive impairment associated with schizophrenia (CIAS). Iclepertin (BI 425809) is a potent and selective inhibitor of glycine transporter‐1 (GlyT1) that was in Phase III development for the ...
Elin M. Matsson   +3 more
wiley   +1 more source

‘Desiccation tolerance of Rhamnidium elaeocarpum Reissek (Rhamnaceae) seeds

open access: yesActa Scientiarum: Agronomy, 2015
This study aimed to investigate the desiccation tolerance of Rhamnidium elaeocarpum Reissek seeds through physiological and biochemical alterations. Fruit were collected from the municipality of Jaupaci, Goias State, Brazil, when the water content of ...
Lílian Abadia da Silva   +5 more
doaj   +1 more source

Purification, characterization and structural determination of chitinases produced by Moniliophthora perniciosa

open access: yesAnais da Academia Brasileira de Ciências, 2012
The enzyme chitinase from Moniliophthora perniciosa the causative agent of the witches' broom disease in Theobroma cacao, was partially purified with ammonium sulfate and filtration by Sephacryl S-200 using sodium phosphate as an extraction buffer ...
Rafaela S. Galante   +8 more
doaj   +1 more source

Relevamiento de la producción de lacasa en aislamientos de Colletotrichum (Ascomycota), agente causal de antracnosis de la Soja [PDF]

open access: yes, 2007
Colletotrichum truncatum es el hongo patógeno más comúnmente asociado con la antracnosis de soja. Aunque la enzima ligninolítica lacasa se relaciona con la patogenicidad de un amplio rango de hongos fitopatógenos, su rol biológico en la interacción ...
Gally, Marcela Edith   +3 more
core  

ZZE-Configuration of chromophore ß-153 in C-phycocyanin from Mastigocladus laminosus [PDF]

open access: yes, 1987
The photochemistry of C-phycocyanin has been studied after denaturation in the dark. It shows an irreversible reaction which has characteristics of a Ζ,Ζ,Ε- to Z,Z,Z-isomerization of dihydrobilins. Its amplitude depends on the reaction conditions, with
Bode, W.   +7 more
core   +1 more source

Determination of LDH Isoenzymes

open access: yesClinical Chemistry, 1966
Abstract A method has been developed for the quantitation of LDH isoenzymes on cellulose acetate paper, taking advantage of the direct fluorometric procedures based on reduced nicotinamide adenine dinucleotide (NADH). The procedure is simple and the reagents relatively stable, allowing the test to become a routine procedure in clinical ...
openaire   +3 more sources

Extrahepatic biliary obstruction secondary to a peritoneopericardial diaphragmatic hernia in a dog

open access: yesVeterinary Record Case Reports, EarlyView.
Abstract A 16‐month‐old, entire, male dobermann presented for evaluation of emesis, anorexia and lethargy. Upon examination, the dog was found to be severely icteric. Serum biochemistry revealed an elevated total bilirubin and alkaline phosphatase, and computed tomographic imaging revealed a peritoneopericardial diaphragmatic hernia with abdominal ...
Emily Durocher   +3 more
wiley   +1 more source

Molecular typing of Leishmania (Leishmania) amazonensis and species of the subgenus Viannia associated with cutaneous and mucosal leishmaniasis in Colombia: A concordance study

open access: yesBiomédica: revista del Instituto Nacional de Salud, 2018
Introduction: Multilocus enzyme electrophoresis (MLEE) is the reference standard for the characterization of Leishmania species. The test is restricted to specialized laboratories due to its technical complexity, cost, and time required to obtain results.
Clemencia Ovalle-Bracho   +3 more
doaj   +1 more source

\u3cem\u3eArabidopsis thaliana\u3c/em\u3e GLX2-1 Contains a Dinuclear Metal Binding Site, but Is Not a Glyoxalase 2 [PDF]

open access: yes, 2009
In an effort to probe the structure and function of a predicted mitochondrial glyoxalase 2, GLX2-1, from Arabidopsis thaliana, GLX2-1 was cloned, overexpressed, purified and characterized using metal analyses, kinetics, and UV–visible, EPR, and 1H-NMR ...
Bennett, Brian   +3 more
core   +2 more sources

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan   +14 more
wiley   +1 more source

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