Results 151 to 160 of about 1,162,423 (312)

The mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to mitochondria. [PDF]

J Cell Biol
Yamashita SI, Arai R, Hada H, Padman BS, Lazarou M, Chan DC, Kanki T, Waguri S.   +7 more
europepmc   +1 more source

Inclusion of proteins into isolated mitochondrial outer membrane vesicles [PDF]

, 1994
Celis, Julio E., Driessen, Arnold, Lill, Roland, Mayer, Andreas, Neupert, Walter   +4 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Purification of murine cortex mitochondria using a modified magnetic bead isolation method. [PDF]

MethodsX
Josic E, Ujevic A, Puljko B, Maček Hrvat N, Lipovcic A, Kalanj-Bognar S, Mlinac-Jerkovic K.   +6 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Extracellular Vesicles: A Comprehensive Review of Their Origins, Functions, and Therapeutic Potential. [PDF]

Biomedicines
Schank MB, Zhao J, Wang L, Moorman JP, Yao ZQ.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Comparison between Different Extracellular Vesicle Isolation Methods by AFM-IR Nanospectroscopy. [PDF]

Anal Chem
da Silva JV, Berenguel O, Neres-Santos RS, Martinho HDS, Carneiro-Ramos MS.   +4 more
europepmc   +1 more source

Mitochondrial ribosomes of neurospora crassa [PDF]

, 1979
Alberghina, Avadhani, Borst, Borst, Cammarano, Datema, de Vries, Drahos, Dure, Hallermayer, Hawley, Kaltschmidt, Kiintzel, Kiintzel, Kroon, Kuriyama, Küntzel, Küntzel, Küntzel, Lambowitz, Lambowitz, Leaver, Lizardi, Lizardi, Loening, Michel, Michel, Michel, Neupert, Neupert, Noll, Nonomura, O'Brien, Ojala, Parish, Peacock, Reijnders, Rifkin, Sala, Sebald, Solymosy, Taylor, van den Bogert, Vasiliev, Vignais, Watson   +45 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source