Results 1 to 10 of about 3,933 (128)

Mechanisms of Isoliquiritigenin Against Protein Glycation: A Comparative Study in PBS Solution and Crowding Environment [PDF]

Foods
The advanced glycation end products generated from protein glycation are associated with the development of diabetic complications. This study aimed to investigate the inhibitory mechanisms of isoliquiritigenin on protein glycation and compare its anti ...
Yushi Wei, Deming Gong, Guowen Zhang
doaj   +2 more sources

Isoliquiritigenin Elicits Potent Antiviral Activity Against Pseudorabies Virus Through Modulating the cGAS/STING and JAK/STAT Signaling Cascades [PDF]

Veterinary Sciences
Pseudorabies virus (PRV), a member of the Alphaherpesvirinae subfamily, poses a significant economic threat to the global swine industry and has raised growing public health concerns due to its cross-species transmission potential.
Hongqiao Hu, Ying Yang, Jinbin Zhang, Yican Wang, Xun Zhou, Lixia Li, Yuanfeng Zou, Mingyue Li, Shujun Dai, Yifei Lang, Xu Song   +10 more
doaj   +2 more sources

Qianjinweijingtang Decoction and Its Granule Inhibit Respiratory Syncytial Virus Infection and the Associated Inflammatory Response. [PDF]

Chem Biodivers
The classical herbal formula Qianjinweijingtang in both decoction and granule forms, exhibits anti‐RSV activity. Isoliquiritigenin, quercetin, and gallic acid are identified as key active compounds. The mechanism involves interfering with viral entry and downregulating HIF‐1α and inflammatory responses, positioning the granule formulation as a ...
Liao CY, Yang ML, Chen ZP, Chen B, Tang YJ, Wang Z, Zhao HN, Deng SH, Ye JH, Liu Z, Chen LF, Li MM.   +11 more
europepmc   +2 more sources

Optimization of response surface methodology for the extraction of isoliquiritigenin from Aspergillus niger solid-state fermentation of licorice and its antitumor effects [PDF]

Frontiers in Pharmacology
This research focused on optimizing the extraction of isoliquiritigenin (ISL) from licorice via a solid-state fermentation process involving Aspergillus niger.
Jingwei Hao, Qiuxuan Li, Nan Dong, Yi Zhou, Yifan Sun, Yingying Pei, Xiangkun Zhou, Lei Yang   +7 more
doaj   +2 more sources

In vitro and in silico evaluation of flavonoids from Erythrina crista-galli with cytotoxic potential against MCF-7 breast cancer cell [PDF]

Scientific Reports
Naturally occurring flavonoids have garnered significant interest as potential anticancer agents owing to their structural diversity and ability to modulate multiple molecular targets. This study aimed to investigate the cytotoxic potential of flavonoids
Tati Herlina, Melati Sukma, Abd. Wahid Rizaldi Akili, Ari Hardianto, Jalifah Latip, Euis Julaeha, Tri Mayanti   +6 more
doaj   +2 more sources

Isoliquiritigenin Inhibits IL-1β-Induced Production of Matrix Metalloproteinase in Articular Chondrocytes

Molecular Therapy - Methods and Clinical Development, 2018
Osteoarthritis (OA) is a major joint disease in which inflammatory cytokine interleukin-1β (IL-1β) and matrix metalloproteinases (MMPs) play a pivotal role. Isoliquiritigenin has been reported to have anti-inflammation activity. In this study, the effect
Lei Zhang, Shiyun Ma, Hang Su, Jiaxiang Cheng   +3 more
exaly   +3 more sources

Isoliquiritigenin targets las, rhl, and Pqs quorum sensing systems to mitigate the virulence and infection of Pseudomonas aeruginosa [PDF]

BMC Microbiology
Pseudomonas aeruginosa is an opportunistic pathogen with high antibiotic resistance, often causing hard-to-treat infections. Its quorum sensing (QS) system regulates virulence and drug resistance. Targeting quorum sensing via QS inhibitors is a promising
Wenxu Song, Zhiying Tian, Yanhong Wang, Yanjie Yin, Haixiang Zhang, Cuixiang Xu, Lixin Shen   +6 more
doaj   +2 more sources

Identification of isoliquiritigenin as a promising compound targeting lactate metabolism for heart failure alleviation [PDF]

Scientific Reports
Lactate metabolism plays a pivotal role in heart failure (HF) progression by exacerbating cardiac fibrosis and dysfunction. However, a systematic analysis of candidate compounds targeting lactate metabolism in HF has not been conducted.
Jingjing Liang, Rui Zhang, Yanggan Wang
doaj   +2 more sources

Snapshots From the Catalytic Landscape of Chalcone Isomerase [PDF]

Plant Direct
ABSTRACT Chalcone isomerase (CHI) catalyzes the cyclization of three‐ring scaffolds of flavonoids, a class of plant‐based natural products important for nutrition and disease prevention. A persistent question has been whether the enzyme uses protein dynamics to facilitate conformational rearrangements of substrates within the active site.
Burke J, Rangel M, Vasquez Meza V, Mims H, Darko T, Ixcoy K, Rivera A, Zhang J, Wolf‐Saxon E, Moorman C.   +9 more
europepmc   +2 more sources

Glycyrrhiza glabra L. Extracts with Potential Antiproliferative and Anti-Migration Activities Against Breast and Gynecological Cancer Cell Lines [PDF]

Plants
Glycyrrhiza glabra L. (Fabaceae) is a plant species with already demonstrated countless biological properties and many more still to be discovered. Here, root sample extracts from different geographical areas were compared based on their phytochemical ...
Maria Rosaria Perri, Carmine Lupia, Máté Vágvölgyi, Attila Hunyadi, Sándor Bartha, Renáta Minorics, István Zupkó, Mariangela Marrelli, Filomena Conforti, Giancarlo Statti   +9 more
doaj   +2 more sources