Results 31 to 40 of about 4,732 (200)
Antioxidants, 2022 Oxidative stress could lead to a variety of body dysfunctions, including neurodegeneration and cancer, which are closely associated with intracellular signal transducers such as reactive oxygen species (ROS).
Zhu Zhang +2 more
doaj +1 more source
Structure-Based Profiling of Potential Phytomolecules with AKT1 a Key Cancer Drug Target
Molecules, 2023 Identifying cancer biomarkers is imperative, as upregulated genes offer a better microenvironment for the tumor; hence, targeted inhibition is preferred.
Zeenat Mirza, Sajjad Karim
doaj +1 more source
Scientific Reports, 2017 Breast cancer is one of the most frightful causes of death among females worldwide. Accumulating evidence attached the importance of microRNAs negative regulation to tumorigenesis in breast cancer, suggesting novel cancer therapies targeting microRNAs ...
Fu Peng +10 more
doaj +1 more source
Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis
Frontiers in Cell and Developmental Biology, 2021 Tubular cell senescence is a common biologic process and contributes to the progression of chronic kidney disease (CKD); however, the molecular mechanisms regulating tubular cell senescence are poorly understood.
Shen Li +11 more
doaj +1 more source
Molecules, 2020 Isoliquiritigenin (IsoLQ) is a flavonoid with antioxidant properties and inducer of endoplasmic reticulum (ER) stress. In vitro and in vivo studies show that ER stress-mediated hormesis is cytoprotective; therefore, natural antioxidants and ER stress ...
Tania Gómez-Sierra +4 more
doaj +1 more source
Isoliquiritigenin Attenuates Atherogenesis in Apolipoprotein E-Deficient Mice [PDF]
International Journal of Molecular Sciences, 2016 Isoliquiritigenin (ISL) exhibits antioxidation and anti-inflammation activity. We sought to investigate the effects and mechanism of ISL on the development of atherosclerotic lesions in apolipoprotein E-deficient (apoE−/−) mice. Firstly, we determined that ISL reduced the mRNA levels of inflammatory factors interleukin 6 (IL-6), tumor necrosis factor α
Fen Du +6 more
openaire +2 more sources
Anti-Cancer Effect of Quercetin in Xenograft Models with EBV-Associated Human Gastric Carcinoma
Molecules, 2016 Licorice extracts have been widely used in herbal and folk medications. Glycyrrhiza contains diverse range of biological compounds including triterpenes (glycyrrhizin, glycyrrhizic acid) and flavonoids (quercetin, liquiritin, liquiritigenin, glabridin ...
Hwan Hee Lee +5 more
doaj +1 more source
Biomedicines, 2022 Chemotherapy is the treatment of choice for gastric cancer; however, the currently available therapeutic drugs for treatment have limited efficacy. Cancer stemness and the tumor microenvironment may play crucial roles in tumor growth and chemoresistance.
Chien-Hsing Lee +8 more
doaj +1 more source
Effects of isoliquiritigenin on ovarian cancer cells
OncoTargets and Therapy, 2018 Ovarian cancer is one of the most fatal gynecologic malignancies, with most patients diagnosed at the late stage due to insidious onset and lack of early onset specific symptoms. Previous studies have implied that isoliquiritigenin (ILQ) is a promising chemopreventive agent against oral cancer.This study aimed to investigate effects of ILQ and ...
Li,Nan +3 more
openaire +3 more sources
Molecules, 2020 Human adipose-derived stem cells (hASCs) can be isolated from fat tissue and have attracted interest for their potential therapeutic applications in metabolic disease.
Hanbyeol Moon +7 more
doaj +1 more source