Results 11 to 20 of about 4,732 (200)
Isoliquiritigenin Protects Neuronal Cells against Glutamate Excitotoxicity
Membranes, 2022 It is considered that glutamate excitotoxicity may be a major factor in the pathological death of neurons and mediate the development of neurodegenerative diseases in humans.
Arina Zgodova +6 more
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Perspectives on the Role of Isoliquiritigenin in Cancer [PDF]
Cancers, 2021 Isoliquiritigenin (2′,4′,4-trihydroxychalcone, ISL), one of the most important bioactive compounds with a chalcone structure, is derived from licorice root. Licorice is commonly known as Glycyrrhiza, including Glycyrrhiza uralensis, Glycyrrhiza radix, and Glycyrrhiza glabra, which are generally available in common foods and Chinese herbal medicines ...
Kai-Lee Wang +2 more
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Plants, 2020 Isoliquiritigenin, a natural chalcone-type flavonoid, has been recognized as an allelochemical with phytotoxicity to lettuce; however, not enough attention has been paid to the mechanisms of this secondary metabolite.
Shuang Zhang +7 more
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Cardiac effects of isoliquiritigenin
European Journal of Pharmacology, 1997 The effects of isoliquiritigenin on force of contraction (Fc), L-type Ca2+ current (I(Ca)) and intracellular Ca2+ concentration ([Ca2+]i) were investigated in rat ventricular heart muscle. Isoliquiritigenin increased Fc and I(Ca) and, after longer exposure times, resting tension and [Ca2+]i.
Wegener, Jörg, Nawrath, Hermann
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The interaction of human sirtuins with isoliquiritigenin
, 2020 Sirtuins are a class of NAD+-dependent deacetylase, catalyzing the removal of acyl group modifications from lysine. Deacylation regulates a wide range of the biological activities such as cell proliferation, insulin secretion, fatty acid metabolism, and ...
易阳旸, Yi, Yangyang
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Molecules, 2019 Glycyrrhizae Radix is widely used as herbal medicine and is effective against inflammation, various cancers, and digestive disorders. We aimed to develop a sensitive and simultaneous analytical method for detecting glycyrrhizin, isoliquiritigenin ...
You Jin Han +4 more
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Isoliquiritigenin Inhibits Atherosclerosis by Blocking TRPC5 Channel Expression [PDF]
Cardiovascular Therapeutics, 2020 Isoliquiritigenin (ISL) is a flavonoid isolated mainly from the licorice plant, a traditional Chinese herb. ISL has shown anticancer, anti-inflammatory, antioxidant, and antidiabetic activities. However, the pharmaceutical effects of ISL on atherosclerosis are seldom explored.
Jie Qi +7 more
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Plant Signaling & BehaviorTobacco black shank (TBS), caused by Phytophthora nicotianae, is a severe disease. Plant root exudates play a crucial role in mediating plant-pathogen interactions in the rhizosphere.
Shiwen Peng +5 more
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Isoliquiritigenin Selectively Inhibits H2 Histamine Receptor Signaling
Molecular Pharmacology, 2006 Isoliquiritigenin, one of the major constituents of Glycyrrhiza uralensis (licorice), is a natural pigment with a simple chalcone structure 4,2',4'-trihydroxychalcone. In this study, isoliquiritigenin showed selective H(2) histamine receptor (H(2)R) antagonistic effect and remarkably reduced several H(2)R-mediated physiological responses. Preincubation
Kim, DC +7 more
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Open Life Sciences, 2017 Isoliquiritigenin (ISL), a member of the flavonoids, is known to possess antitumor activity in different types of cancer including human breast cancer, hepatoma cancer, prostate cancer and others, both in vitro and in vivo.
Huang Ya-Li +5 more
doaj +2 more sources