Results 71 to 80 of about 4,732 (200)

Isoliquiritigenin inhibits the proliferation, apoptosis and migration of osteosarcoma cells

Oncology Reports, 2019
The overall survival rate of patients with osteosarcoma has remained unchanged for the last several decades. Therefore, novel drugs for osteosarcoma treatment are required. Isoliquiritigenin (ISL), a natural compound, has been demonstrated to inhibit the growth of various tumors.
Chengjun, Li, Xing, Zhou, Chang, Sun, Xiaozhou, Liu, Xin, Shi, Sujia, Wu   +5 more
openaire   +3 more sources

Isoliquiritigenin showed strong inhibitory effects towards multiple UDP-glucuronosyltransferase (UGT) isoform-catalyzed 4-methylumbelliferone (4-MU) glucuronidation

, 2013
Isoliquiritigenin, a herbal ingredient with chalcone structure, has been speculated to be able to inhibit one of the most drug-metabolizing enzymes (DMEs) UDP-glucuronosyltransferase (UGT).
Liu, Yan, Li, Hua, Fu, Xiaoguang, Lu, Hang, Sun, Hongzhi, Hu, Cui-Min, Sun, Xiao-Yu, Cao, Yun-Feng, Hong, Mo, Fang, Zhong-Ze   +9 more
core   +1 more source

Isoliquiritigenin Activates Nuclear Factor Erythroid-2 Related Factor 2 to Suppress the NOD-Like Receptor Protein 3 Inflammasome and Inhibits the NF-κB Pathway in Macrophages and in Acute Lung Injury

Frontiers in Immunology, 2017
Among the cellular response mechanisms, the nuclear factor erythroid-2 related factor 2 (Nrf2) pathway is considered a survival pathway that alleviates oxidative injury, while both the NOD-like receptor protein 3 (NLRP3) and NF-κB pathways are pro ...
Qinmei Liu, Hongming Lv, Zhongmei Wen, Xinxin Ci, Liping Peng   +4 more
doaj   +1 more source

Natural Product‐Derived Vesicles in Nanotherapeutics

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Natural product‐derived vesicles (NPVs) are an emerging nature‐based nanotherapeutic that can deliver bioactive metabolites into the target site and induce beneficial mechanisms. A practical, chronological bench‐to‐bedside approach throughout the entire NPV development process is expected to resolve challenges encountered in NPV studies.
Kartiko Arif Purnomo, Tsong‐Long Hwang
wiley   +1 more source

A Perspective of Soy Isoflavones on Analytical, Biological, and Chemical Attributes

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT This review covers key aspects of soybean (Glycine max), with a particular focus on its isoflavone content and biological properties. Soybeans maintain their position as both a nutraceutical and a pharmaceutical crop, with a broad range of dietary items used worldwide, including soy milk, fermented soy products, and various dietary supplements.
Sristy Suman, Joydeep Chatterjee, Gaurav Joshi, Raj Kumar, Muhammad Wahajuddin   +4 more
wiley   +1 more source

Therapeutic Potential of Chickpea‐Derived Bioactives: A Review With Perspective of Different In Vitro, Animal, and Human Studies

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Chickpea (Cicer arietinum L.) is an important dietary legume worldwide and provides micronutrients and phytochemicals, including phenolics, flavonoids, carotenoids, bioactive peptides, dietary fiber, and resistant starch. This narrative review summarizes evidence from in vitro, animal, and human studies on the potential health relevance of ...
Rohama Shahid, Maria Maqsood, Nimrah Ashraf, Farzeen Asghar, Nauman Khalid   +4 more
wiley   +1 more source

Isoliquiritigenin Ameliorates Indomethacin-Induced Small Intestinal Damage by Inhibiting NOD-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation

, 2018
Activation of the NOD-Like Receptor Family, Pyrin Domain-Containing 3 (NLRP3) inflammasome, which consists of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and pro-caspase-1, triggers pro-caspase-1 cleavage
Sunao Shimada, Toshio Watanabe, Masaki Iimuro, Shiro Nakamura, Takako Miyazaki, Yuji Nadatani, Yasuhiro Fujiwara, Tetsuya Tanigawa   +7 more
core   +1 more source

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source

Anti‐Aging Potential of Callus Culture: Mechanisms, Efficacy and Future Trends

Journal of Cosmetic Dermatology, Volume 25, Issue 9, September 2026.
ABSTRACT Background Callus culture technology revolutionizes skin antiaging research, offering a sustainable and efficient method for producing bioactive compounds with potent geroprotective properties. This plant tissue and cell culture technique enables the controlled biosynthesis of beneficial phytochemicals while mitigating the variability and ...
Amir Mohammad Sharafi, Ali Khajeei, Maryam Hasan Zadeh Navroodi, Soheila Mokari, Seydeh Halimeh Najafi, Mohaddeseh Argha, Faezeh Talaei Shahmirzadi, Parina Asgharian, Tooba Gholikhani   +8 more
wiley   +1 more source

Dietary Compound Isoliquiritigenin Inhibits Breast Cancer Growth And Neoangiogenesis Via Blocking Vegf/vegfr-2 Signaling Pathway [PDF]

, 2013
Angiogenesis is crucial for cancer initiation, development and metastasis. Identifying natural botanicals targeting angiogenesis has been paid much attention for drug discovery in recent years, with the advantage of increased safety.
Yu, L, Wang, Z, WANG, N, Jianping Chen, Shen, J, Dongmei Wang, Han, S, Wang, D, Mo, S, Tsui, K, Shouwei Han, Chen, J, Zhiyu Wang, Kamchuen Tsui, Suilin Mo, Huang, H, Hui Huang, Jiangang Shen, Linzhong Yu, Neng Wang   +19 more
core   +1 more source