Results 11 to 20 of about 12,847 (298)

Application-Oriented Marine Isomerases in Biocatalysis

Marine Drugs, 2020
The class EC 5.xx, a group of enzymes that interconvert optical, geometric, or positional isomers are interesting biocatalysts for the synthesis of pharmaceuticals and pharmaceutical intermediates.
Antonio Trincone
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Dual-Family Peptidylprolyl Isomerases (Immunophilins) of Select Monocellular Organisms

Biomolecules, 2018
The dual-family peptidylprolyl cis-trans isomerases (immunophilins) represent a naturally occurring chimera of the classical FK506-binding protein (FKBP) and cyclophilin (CYN), connected by a flexible linker.
Sailen Barik
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Editorial: Peptidyl-Prolyl Isomerases in Human Pathologies [PDF]

Frontiers in Pharmacology, 2019
Editorial on the Research Topic: Peptidyl-prolyl Isomerases in Human ...
Tiziano Tuccinardi, Flavio Rizzolio, Flavio Rizzolio   +2 more
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Downregulated miR-181a alleviates H2O2-induced oxidative stress and cellular senescence by targeting PDIA6 in human foreskin fibroblasts [PDF]

Anais Brasileiros de Dermatologia, 2023
Background Oxidative stress is strongly associated with cellular senescence. Numerous studies have indicated that microRNAs (miRNAs) play a critical part in cellular senescence.
Yan Huang, Huimin Yan, Yanqing Yang, Jinfei Zhou, Qijun Xu, Hu Meng   +5 more
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Thiol isomerases orchestrate thrombosis and haemostasis [PDF]

, 2021
Since protein disulphide isomerase (PDI) was first described in 1963, researchers have shown conclusively that PDI and sibling proteins are quintessential for thrombus formation.
Gibbins, Jonathan M., Simoes Gaspar, Renato   +1 more
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Glutathione Transferases as Efficient Ketosteroid Isomerases

Frontiers in Molecular Biosciences, 2021
In addition to their well-established role in detoxication, glutathione transferases (GSTs) have other biological functions. We are focusing on the ketosteroid isomerase activity, which appears to contribute to steroid hormone biosynthesis in mammalian ...
Bengt Mannervik, Aram Ismail, Helena Lindström, Birgitta Sjödin, Nancy H. Ing   +4 more
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Comparative Genome Analyses of Plant Rust Pathogen Genomes Reveal a Confluence of Pathogenicity Factors to Quell Host Plant Defense Responses

Plants, 2022
Switchgrass rust caused by Puccinia novopanici (P. novopanici) has the ability to significantly affect the biomass yield of switchgrass, an important biofuel crop in the United States. A comparative genome analysis of P.
Raja Sekhar Nandety, Upinder S. Gill, Nick Krom, Xinbin Dai, Yibo Dong, Patrick X. Zhao, Kirankumar S. Mysore   +6 more
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Myricetin, the Main Flavonoid in Syzygium cumini Leaf, Is a Novel Inhibitor of Platelet Thiol Isomerases PDI and ERp5

Frontiers in Pharmacology, 2020
BackgroundFlavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid. Little is
Renato Simões Gaspar, Renato Simões Gaspar, Samira Abdalla da Silva, Jennifer Stapleton, João Lucas de Lima Fontelles, Hiran Reis Sousa, Vinicyus Teles Chagas, Shuruq Alsufyani, Andrés Trostchansky, Jonathan M. Gibbins, Antonio Marcus de Andrade Paes   +10 more
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Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps [PDF]

, 2016
Cyclophilins are ubiquitous cis-trans-prolyl isomerases (PPIases) found in all kingdoms of life. Here, we identify a novel family of cyclophilins, termed AquaCyps, which specifically occurs in marine Alphaproteobacteria, but not in related terrestric ...
Timm Maier, Franz X Schmid, Maier, Timm, Philipp A. M. Schmidpeter (453850), Jakob, Roman P., Johanna R. Koch (2825327), Schmidpeter, Philipp A. M., Franz X. Schmid (1748071), Schmid, Franz X., Philipp A M Schmidpeter, Johanna R Koch, Roman P. Jakob (1637830), Roman P Jakob, Koch, Johanna R., Timm Maier (1637839)   +14 more
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Structure analysis suggests Ess1 isomerizes the carboxy-terminal domain of RNA polymerase II via a bivalent anchoring mechanism

Communications Biology, 2021
Namitz, Zheng et al. identify a bivalent interaction by the yeast Ess1 with CTD peptides of RNA polymerase II. Their results suggest an anchored mechanism of isomerization, and raise the possibility of eukaryotic parvulin-class prolyl isomerases gaining ...
Kevin E. W. Namitz, Tongyin Zheng, Ashley J. Canning, Nilda L. Alicea-Velazquez, Carlos A. Castañeda, Michael S. Cosgrove, Steven D. Hanes   +6 more
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