Results 211 to 220 of about 20,307 (268)

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, Volume 111, Issue 4, Page 2026-2043, 1 April 2026.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Hidden β-γ Dehydrogenation Products in Long-Chain Fatty Acid Oxidation Unveiled by NMR: Implications on Lipid Metabolism. [PDF]

ACS Bio Med Chem Au
Fabbian S, Masciovecchio B, Schievano E, Giachin G.   +3 more
europepmc   +1 more source

Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual‐Acting Compounds

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
This study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Antonino N. Fallica, Carla Barbaraci, M. Carmen Ruiz‐Cantero, Arianna Scarlatti, Alessandro Coco, Giorgia Giordano, Alfonsina La Mantia, Orazio Prezzavento, Antonio Di Stefano, Ivana Cacciatore, Giacomo Siano, Antonino Cattaneo, Lorella Pasquinucci, Enrique J. Cobos, Cristina Di Primio, Emanuele Amata, Agostino Marrazzo   +16 more
wiley   +1 more source

<i>De novo</i> transcriptome dataset of the cyanogenic fern <i>Phlebodium aureum</i> 'Mandaianum'. [PDF]

Data Brief
Tomescu S, Rumbold K, Sooklal SA.
europepmc   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Inhibitors of peptidyl proline isomerases as antivirals in hepatitis C and other viruses.

PLoS Pathogens, 2014
Rob Striker, Andrew Mehle
doaj   +1 more source

Dual-functional quorum sensing signal synthases DspII and DspI coordinate virulence switch in Pseudomonas aeruginosa. [PDF]

Nat Commun
Huang J, Zhou T, Zhou X, Xue Y, Zhao W, Liao L, Chang C, Zhang LH, Xu Z.   +8 more
europepmc   +1 more source

The sigma-1 receptor as a neurohomeostatic decision hub for GABARAP-mediated receptor trafficking and macroautophagy. [PDF]

Front Mol Biosci
Baeken MW, Bekbulat F, Körschgen H, Clement AM, Behl C.   +4 more
europepmc   +1 more source

Integrated metabarcoding and culture-dependent assessments reveal <i>Pseudomonas</i> as dominant hyphosphere-pathobiont in Race 4 <i>Fusarium</i> wilt pathogen of cotton. [PDF]

Front Microbiol
Antony-Babu S, Abeysinghe G, Thomas VE, Hockenbury C, Parunandi SS, Dasgupta A, Gregory TA, Gabu AS, Ball H, Chappell TM, Shaw BD, Isakeit T, Pierson EA.   +12 more
europepmc   +1 more source

Recent advances in vascular thiol isomerases and redox systems in platelet function and thrombosis. [PDF]

J Thromb Haemost
Essex DW, Wang L.
europepmc   +1 more source