Results 61 to 70 of about 12,847 (298)

PROTEIN BIOTECHNOLOGY: THE SIGNIFICANCE AND USE OF INDUSTRIAL POLYMER-DEGRADING ENZYMES [PDF]

مجلة جامعة كركوك للعلوم الزراعية
Microorganisms are the primary source of industrial enzymes, with Bacillus and Aspergillus species being the leading producers. Bacillus strains have historically been used to synthesize commercially significant enzymes due to their status as GRAS ...
Mustafa Omar
doaj   +1 more source

Analyzing Current Trends and Possible Strategies to Improve Sucrose Isomerases’ Thermostability

, 2023
Due to their ability to produce isomaltulose, sucrose isomerases are enzymes that have caught the attention of researchers and entrepreneurs since the 1950s. However, their low activity and stability at temperatures above 40 °C have been a bottleneck
Quintín Rascón-Cruz, Lourdes Ballinas-Casarrubias, Sigifredo Arévalo-Gallegos, Liber Mesa-Ramos, Edward Alexander Espinoza-Sánchez, Tania Samanta Siqueiros-Cendón, Blanca Flor Iglesias-Figueroa, Norma Rosario Flores-Holguín, Amado Javier Sardiña-Peña   +8 more
core   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Inhibition of Phosphoglucose Isomerase [PDF]

Nature, 1956
THE key carbohydrate intermediate, glucose 6-phosphate, which may follow several alternative metabolic pathways including the 6-phosphogluconate oxidative cycle and the glycolytic sequence, enters the latter route by the phosphoglucose isomerase reaction.
openaire   +2 more sources

Mycobacterium tuberculosis Peptidyl-Prolyl Isomerases Also Exhibit Chaperone like Activity In-Vitro and In-Vivo. [PDF]

PLoS ONE, 2016
Peptidyl-prolyl cis-trans isomerases (Ppiases), also known as cyclophilins, are ubiquitously expressed enzymes that assist in protein folding by isomerization of peptide bonds preceding prolyl residues.
Saurabh Pandey, Ashish Sharma, Deeksha Tripathi, Ashutosh Kumar, Mohd Khubaib, Manish Bhuwan, Tapan Kumar Chaudhuri, Seyed Ehtesham Hasnain, Nasreen Zafar Ehtesham   +8 more
doaj   +1 more source

Thiol isomerases negatively regulate the cellular shedding activity of ADAM17

, 2010
ADAM17 (where ADAM is 'a disintegrin and metalloproteinase') can rapidly modulate cell-surface signalling events by the proteolytic release of soluble forms of proligands for cellular receptors.
Tape, Christopher J, Sofie H. Willems, Willems, Sofie H, Stanley, Peter L, Stanley, Peter L. D., Murphy, Gillian, John McCafferty, Peter L. Stanley, Gillian Murphy, Tape, Christopher James, Neal, David E, Christopher J. Tape, Mills, Ian G, Taylor, Neil A, Ian G. Mills, Neil A. Taylor, McCafferty, John, David E. Neal, Mills, Ian G; id_orcid   +18 more
core   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

A Guide to PIN1 Function and Mutations Across Cancers

Frontiers in Pharmacology, 2019
PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis–trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability.
Maguie El Boustani, Maguie El Boustani, Lucia De Stefano, Lucia De Stefano, Isabella Caligiuri, Nayla Mouawad, Nayla Mouawad, Carlotta Granchi, Vincenzo Canzonieri, Tiziano Tuccinardi, Antonio Giordano, Flavio Rizzolio, Flavio Rizzolio   +12 more
doaj   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

HPW-RX40 prevents human platelet activation by attenuating cell surface protein disulfide isomerases

Redox Biology, 2017
Protein disulfide isomerase (PDI) present at platelet surfaces has been considered to play an important role in the conformational change and activation of the integrin glycoprotein IIb/IIIa (GPIIb/IIIa) and thus enhances platelet aggregation.
Po-Hsiung Kung, Pei-Wen Hsieh, Ying-Ting Lin, Jia-Hau Lee, I-Hua Chen, Chin-Chung Wu   +5 more
doaj   +1 more source