Results 81 to 90 of about 12,847 (298)
Arthritis &Rheumatology, EarlyView.Objective To identify autoantibodies in presymptomatic individuals that associate with the onset of rheumatoid arthritis (RA) and to distinguish early RA from osteoarthritis (OA), particularly in individuals lacking classic RA serologic markers. Methods We analyzed serum and plasma from three cohorts: presymptomatic individuals who later developed RA ...
Outi Sareila +12 more
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased inflammatory markers. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen +10 more
wiley +1 more source
Frontiers in Immunology, 2019 Platelets play an essential role in maintaining homeostasis in the circulatory system after an injury by forming a platelet thrombus, but they also occupy a central node in the intravascular innate immune system.
Oskar Eriksson +4 more
doaj +1 more source
Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationships
, 2015 BACKGROUND: The p53 protein family, comprising p53, p63 and p73, is primarily involved in preserving genome integrity and preventing tumor onset, and also affects a range of physiological processes.
Mantovani, Fiamma +3 more
core +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT The agitation power input substantially impacts the oxygen transfer rate in aerobic fermentation processes. Furthermore, in a carbon‐limited process where the substrate feed rate is controlled by the concentration of dissolved oxygen, the power input will consequently govern the feed rate.
Mariana Albino +6 more
wiley +1 more source
Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases
, 2019 Chalcone isomerases are plant enzymes that perform enantioselective oxa-Michael cyclizations of 2′-hydroxychalcones into flavanones. An X-ray crystal structure of an enzyme–product complex combined with molecular dynamics simulations reveal an enzyme ...
Anna Pabis +29 more
core +2 more sources
, 2005 Click on the DOI link to access the articleIn Escherichia coli, FkpA, PpiA, PpiD, and SurA are the four known periplasmic cis-trans prolyl isomerases.
Reiss Harper, Jill +10 more
core +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian +4 more
wiley +1 more source
The chemistry and evolution of enzyme function: isomerases as a case study
, 2015 The study of the evolution of proteins has been traditionally undertaken from a sequence and structural point of view. However any attempt to understand how protein function changes during evolution benefits from consistent definitions of function and ...
core +1 more source