Results 101 to 110 of about 12,847 (298)

A Library of Fluorescent Peptides for Exploring the Substrate Specificities of Prolyl Isomerases

, 2016
To fully explore the substrate specificities of prolyl isomerases, we synthesized a library of 20 tetrapeptides that are labeled with a 2-aminobenzoyl (Abz) group at the amino terminus and a p-nitroanilide (pNA) group at the carboxy terminus.
Franz X. Schmid (1748071), Tobias Aumüller (1715917), Gunter Fischer (727208), Jozef Hritz (525435), Chris Oostenbrink (6928), Christian Lücke (1977286), Gabriel Zoldák (2090035)   +6 more
core   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 mediates late-phase PGE2 production in bone marrow derived macrophages.

PLoS ONE, 2012
Cyclooxygenase (COX)-2 expression and release of prostaglandins (PGs) by macrophages are consistent features of lipopolysaccharide (LPS)-induced macrophage inflammation.
Lei Xiao, Magdalena Ornatowska, Guiqing Zhao, Hongmei Cao, Rui Yu, Jing Deng, Yongchao Li, Qiong Zhao, Ruxana T Sadikot, John W Christman   +9 more
doaj   +1 more source

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Democratized Discovery of Microsclerodermin F as an Immunophilin Ligand

Marine Drugs
While immunophilins are well-recognized therapeutic targets, several members of this family of peptidyl-proline isomerases (PPIases) have yet to be subjected to ligand discovery efforts.
Manfred Auer, Malcolm D. Walkinshaw, Jacqueline Dornan, Nhan T. Pham, Xinru Xue, Miaomiao Liu, Ronald J. Quinn, Eric M. Ross, Abimael D. Rodríguez, James J. La Clair   +9 more
doaj   +1 more source

Involvement of peptidylprolyl cis/trans isomerases in Enterococcus faecalis virulence

, 2012
Peptidylprolyl cis/trans isomerases (PPIases) are enzymes involved in protein folding. Analysis of the genome sequence of Enterococcus faecalis V583 allowed for identification of 3 PPIases carrying genes.
Connil, Nathalie, Chevalier, Sylvie, Rince, Alain, A., Camilli, A., Posteraro, Brunella, Reffuveille, Fany, F., Posteraro, Brunella, B., Sanguinetti, Maurizio, Auffray, Yanick   +8 more
core   +1 more source

Combining phenotypic, physiological, and multi‐omics studies to provide new insights on the role of 2,4‐epibrassinolide in regulation of seed shattering in Elymus sibiricus L.

Grassland Research, EarlyView.
Abstract Background Seed shattering limits the production of Elymus sibiricus L., and application of exogenous brassinosteroid significantly alleviates plant organ abscission. Methods To explore the potential regulatory network of brassinosteroid on seed shattering, the abscission zone of E. sibiricus cv. Lanyu No.
Huanhuan Lu, Yiyang Wan, Liuban Tang, Yongsen Qiu, Yancui Zhao, Yuying Zheng, Wengang Xie   +6 more
wiley   +1 more source

Learning from B12 enzymes: biomimetic and bioinspired catalysts for eco-friendly organic synthesis

Beilstein Journal of Organic Chemistry, 2018
Cobalamins (B12) play various important roles in vivo. Most B12-dependent enzymes are divided into three main subfamilies: adenosylcobalamin-dependent isomerases, methylcobalamin-dependent methyltransferases, and dehalogenases. Mimicking these B12 enzyme
Keishiro Tahara, Ling Pan, Toshikazu Ono, Yoshio Hisaeda   +3 more
doaj   +1 more source

Molecular determinants of allosteric modulation of protein disulfide isomerase by small-molecule b′-ligands

Redox Biology
Allosteric modulation is central to enzyme function and an attractive strategy for drug development. Protein Disulfide Isomerase (PDI), the prototypical thiol-isomerase, exemplifies this potential through its structural flexibility and involvement in ...
Nathan Ponzar, Anna Pagotto, Srija Bandyopadhayay, Marvin J. Meyers, Vincenzo De Filippis, Robert Flaumenhaft, Nicola Pozzi   +6 more
doaj   +1 more source

Protein disulfide isomerases - a way to tackle malaria.

Protein disulfide isomerases (PDIs) ensure that specific substrate proteins are correctly folded. PDI activity plays an essential role in malaria transmission.

core   +1 more source