Results 131 to 140 of about 475 (151)

Isometamidium in pigs: disposition kinetics, tissue residues and adverse reactions

Research in Veterinary Science, 1991
The disposition and adverse effects of the anti-trypanosomal drug isometamidium in pigs were evaluated. Following intramuscular administration of the drug at doses of 0.5, 15 and 35 mg kg-1, the drug was rapidly absorbed within 15 to 30 minutes to reach maximum plasma concentrations of 12 to 477 (n = 6), 302 to 655 (n = 4) and 1620 (n = 1) ng ml-1 ...
L D, Kinabo, Q A, McKellar, P D, Eckersall   +2 more
openaire   +2 more sources

Metabolism of isometamidium in hepatocytes isolated from control and inducer‐treated rats

Journal of Veterinary Pharmacology and Therapeutics, 2006
Little is known about the metabolism and mechanism of action of the trypanocide, isometamidium (ISM), the major drug used for prophylaxis of trypanosomiasis. We have investigated its metabolism and distribution in isolated rat hepatocytes using liquid chromatography‐mass spectrometry and confocal laser scanning microscopy (CLSM).
I, Boibessot, J N A, Tettey, G G, Skellern, D G, Watson, M H, Grant   +4 more
openaire   +2 more sources

Susceptibility of dyskinetoplastic Trypanosoma evansi and T. equiperdum to isometamidium chloride

Parasitology Research, 1997
Isometamidium chloride (ISM) is an effective trypanocide with curative and prophylactive activity in husbandry animals. The mode of action of ISM against pathogenic trypanosomes is not fully understood, but there is evidence in the literature that kinetoplastic topoisomerase type II is selectively inhibited by the drug.
R, Kaminsky, C, Schmid, Z R, Lun
openaire   +2 more sources

The Toxic Effect of Intravenous Application of the Trypanocide Isometamidium (Samorin®)

Zentralblatt für Veterinärmedizin Reihe A, 1985
SummaryFor the trypanocide isometamidium chloride (Samorin®, May & Baker) the intramuscular route is recommended by the suppliers but application by this route is followed by local tissue irritation and necrosis. The intravenous administration leads to a dose‐dependent acute systemic toxicity, which can be fatal.
D, Schillinger, S H, Maloo, D, Röttcher
openaire   +2 more sources

Influence of nutrition on trypanosome isometamidium chloride chemoprophylaxis

Animal Research International, 2012
Thirty six weaner wistar rats were used to study the effect of protein nutrition on trypanosome isometamidium chloride prophylaxis. Two groups of rats A and B (n = 18 per group) were maintained on 21% and 14.5% crude protein diet respectively for the twenty eight days.
Nnadi, PA, Onyeyili, PA
openaire   +1 more source

Some Effects of the Trypanocidal Drug Isometamidium on Encapsulation in Bovine Carrier Erythrocytes

Biotechnology and Applied Biochemistry, 1988
Bovine erythrocyte exposure to isometamidium chloride causes increased osmotic fragility. Control cells tolerated up to 1 mg/ml drug with no effects. Carrier erythrocytes were highly susceptible to drug, with increased osmotic fragility and decreased encapsulation potential of sucrose and inulin.
J R, DeLoach, G G, Wagner
openaire   +2 more sources

Absence of correlation between karyotype profiles of Trypanosoma congolense and resistance to isometamidium chloride

Veterinary Parasitology, 2007
Chromosome profiles of 10 Trypanosoma (T.) congolense populations with different isometamidium sensitivities were compared using the pulsed field gel electrophoresis technique. The aim was to elucidate whether there was a karyotype pattern specific to eight isometamidium resistant phenotypes.
Francis, Shahada, Peter-Henning, Clausen, Uwe, Tietjen, Takehisa, Chuma, Karoku, Okamoto   +4 more
openaire   +2 more sources

A Simple Competitive Enzyme Immunoassay for the Detection of the Trypanocidal Drug Isometamidium

Therapeutic Drug Monitoring, 1996
A new competitive enzyme immunoassay technique has been developed for the determination of concentrations of the trypanocidal drug isometamidium chloride (Samorin) in bovine serum. The method has been shown to be highly repeatable and reproducible, and it has several advantages over previous immunoassay techniques for the drug.
Eisler, MC, Elliott, CT, Holmes, PH
openaire   +2 more sources

Influence of atropine on the acute toxicity of isometamidium.

Veterinary and human toxicology, 1993
The effectiveness of atropine in blocking the acute toxic effects of the antitrypanosomal drug isometamidium (ISMM) was evaluated in mice and goats using lethality as the primary index. The median lethal dose (LD50) of ISMM in nonatropinized mice was 45.3 mg/kg bodyweight (SE +/- 5.3 mg/kg bodyweight), whereas the LD50 of ISMM in mice pre-treated with ...
A A, Gimbi, L D, Kinabo
openaire   +1 more source

Action of isometamidium chloride on the insect vector form of Trypanosoma vivax

Research in Veterinary Science, 1985
The effect of isometamidium chloride upon developing and mature Trypanosoma vivax occurring in Glossina palpalis palpalis flies was evaluated. Newly emerged G p palpalis flies were infected with T vivax by allowing them to feed on parasitaemic animals. Two experiments were conducted and in each the flies were divided into two groups.
openaire   +2 more sources