Results 171 to 180 of about 86,651 (264)

Immunomodulatory Effects of Zinc and Selenium‐Enriched Lentinula edodes Extract: Biochemical Characterization and Bioactivity Relevant to Tuberculosis

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Graphical representation of overall study. ABSTRACT The primary hypothesis of the study was that zinc and selenium supplementation through fortified cookies would enhance the immune response and improve clinical outcomes in tuberculosis patients. For this purpose, a single‐blind randomized control trial was carried out to determine the effect of zinc ...
Hanif Mughal, Tabussam Tufail, Huma Bader ul Ain, Amara Rasheed, Esther Ugo Alum   +4 more
wiley   +1 more source

Real-World Assessment of the Xpert MTB/XDR for Detecting Isoniazid and Second-Line Drug Resistance Among TB Patients. [PDF]

Int J Mol Sci
Makhon A, Fuchs S, Rubinstein M, Brodsky M, Dveyrin Z, Tejman-Yarden N, Losev Y.   +6 more
europepmc   +1 more source

Hematological Profiles of Pulmonary Tuberculosis and Multi‐Drug‐Resistant Tuberculosis Patients at Debre Tabor Comprehensive Specialized Hospital, North‐Central Ethiopia: A Comparative Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Tuberculosis is a major infectious disease that affects hematological profiles. However, limited data assess changes in hematological profiles among patients with pulmonary and multidrug‐resistant tuberculosis. Therefore, this study aimed to compare the hematological profiles of pulmonary and multidrug‐resistant ...
Ayenew Berhan, Bekele Sharew, Andargachew Almaw, Shewaneh Damtie, Biruk Legese, Mulat Erkihun, Ayenew Assefa, Birhanemaskal Malkamu, Getu Abeje, Birhanu Getie, Yenealem Solomon   +10 more
wiley   +1 more source

Strengthening Pharmacogenomics Implementation in Africa: Challenges and Opportunities ‐ A Narrative Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aim The discipline of pharmacogenomics (PGx) studies the influence of genetic diversity on drug response, bringing the potential to personalized treatment and reduction of adverse effects. Although PGx integration into healthcare is progressing at a global scale, its implementation in Africa faces unique challenges and ...
Esther Mukabyiringiro, Andrew Wainaina Kinyanjui, Gachie Ruth Nthenya, Okoth Zifion Ndiege, Daniel Alaak Majok, Samuel Inshutiyimana, Ermias Mergia Terefe   +6 more
wiley   +1 more source

Tuberculosis prevention in children, adolescents, and pregnant and postpartum women in South Africa. [PDF]

S Afr Fam Pract (2004)
Rabe M, Hughes JA.
europepmc   +1 more source

Prenatal Diagnosis of Autosomal Recessive Primary Microcephaly Type 2 Caused by Compound Heterozygous WDR62 Variants in a Family With Two Recurrent Cases

Molecular Genetics &Genomic Medicine, Volume 14, Issue 4, April 2026.
We report prenatal diagnosis of MCPH2 via trio‐WES, identifying novel compound heterozygous WDR62 variants. To our knowledge, prenatal MRI detection of lobar HPE and lissencephaly with the agyria–pachygyria complex has not been reported in fetuses with WDR62 variants. Consequently, these findings have advanced our understanding of prenatally detectable
Yan‐Fang Li, Song‐Hui Zhang, Li Zhen, Lan‐Zhen Zhang   +3 more
wiley   +1 more source

Isoniazid-induced alopecia in isoniazid-monoresistant pulmonary tuberculosis. [PDF]

BMC Pulm Med
Afşin E, Özkara Ş, Gökdemir FC.
europepmc   +1 more source

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, Volume 15, Issue 4, April 2026.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source

Outcomes of isoniazid preventive therapy in pregnant women living with HIV: A systematic review and meta-analysis. [PDF]

Int J Immunopathol Pharmacol
Shahid S, Karimi H, Ahmad B, Hafeez U, Ayalew BD, Abdullah.   +5 more
europepmc   +1 more source

Identification and Characterisation of the Gene Cluster Governing Biosynthesis of the Anti‐Mycobacterial Antibiotic Acidomycin

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Biosynthetic gene cluster for antibiotic acidomycin targeting biotin biosynthesis in mycobacteria was identified in a Streptomyces bacterium, and its identity was confirmed by gene knockout and heterologous expression. This cluster is located in proximity to the genes cluster for stravidins targeting a different step in the biotin biosynthesis pathway.
Anna Vignolle, Martin Zehl, Jaime Felipe Guerrero Garzón, Olha Schneider, Johannes Gafriller, Ulrike Grienke, Rasmus H. Kirkegaard, Sergey B. Zotchev   +7 more
wiley   +1 more source