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The Isoniazid Debate

Archives of Internal Medicine, 1991
To the Editor. — We read with interest Colice's article 1 in which he repeats our analysis of isoniazid preventive therapy 2 using somewhat different data. We were gratified to find that our model and assumptions were explicated in sufficient detail to allow its independent recreation.
Joel Tsevat   +3 more
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Applesauce and Isoniazid

Pediatrics, 1987
To the Editor.— Notterman et al (Pediatrics 1986;77:850-852) reported about an 8-month-old infant who absorbed crushed isoniazid in applesauce poorly both during treatment for tuberculous meningitis and later in pharmacokinetic studies. A second child exhibited a less severe malabsorption.
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Microdetermination of Isoniazids*

Journal of the American Pharmaceutical Association (Scientific ed.), 1953
A method is detailed for the assay of isoniaaids. It depends upon the reduction of ferricyanide by the hydrazide in acid solution with subsequent estimation of the color produced with the aid of a photoelectric colorimeter. The method is simple, relatively raid, and requires apparatus commonly available in chemical, pharmaceutical, ancf clinical ...
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Isoniazid Interactions

Southern Medical Journal, 1985
Isoniazid is an antituberculous drug that is usually administered for nine to 12 months. The potential for clinically important interactions exists because this drug is a potent inhibitor of drug metabolism. Studies and case reports have shown that isoniazid inhibits the metabolism of several drugs, including phenytoin, carbamazepine, anticoagulants ...
A M, Baciewicz, T H, Self
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Isoniazid in leprosy

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1955
Abstract 1. (1)Isoniazid was given alone in a 17- to 26-month trial in six patients, five with lepromatous leprosy, and one with tuberculoid leprosy, who had responded poorly to, or had had repeated lepra reactions from, the sulphone group of drugs. 2. (2) The dosage was never less than 3.9 mg/kg. body weight, and usually 8 to 9 mg/kg.
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Isoniazid and Levodopa

Annals of Internal Medicine, 1980
Excerpt To the editor: The letter of Lejonc and colleagues (1) in the November 1979 issue on a patient who developed flushing and palpitations and, later, elevated pulse rate and blood pressure as ...
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An Immunohematologic Complication of Isoniazid

Vox Sanguinis, 1978
Abstract. The characteristics of an immunohematologic reaction to isoniazid are described with emphasis on the mechanism of development of the positive antiglobulin test. In contrast to previous findings, the antibody is a firmly bound IgG complement‐binding antibody, reacting best at 37°C by antiglobulin techniques and only with isoniazid ...
F. C. Lim, Jane E. Freedman
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Isoniazid-induced pellagra

Cutaneous and Ocular Toxicology, 2011
Pellagra is characterized by dermatitis, diarrhea, dementia and eventually death occurring as a result of niacin or its precursor tryptophan deficiency. Although pellagra is a well-known complication of isoniazid (INH) therapy, the clinical diagnosis may be missed or delayed that may cause life-threatening consequences. Due to the diversity of pellagra-
ÇALKA, Omer   +3 more
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Prevention of isoniazid tumorigenicity by antitoxicants of isoniazid in Swiss mice

Journal of Cancer Research and Clinical Oncology, 1980
Effect of isoniazid on blood ammonia levels and protein biosynthesis in tissues of Swiss mice was studied. Isoniazid treatment resulted in an elevation of the blood ammonia. It inhibited the protein biosynthesis in lung and kidney tissues of Swiss mice after 24 h of treatment.
S. V. Bhide, Girish B. Maru, M. M. Sawai
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