Results 11 to 20 of about 2,381,535 (223)

Isoniazid Preventive Therapy and Risk for Resistant Tuberculosis [PDF]

Emerging Infectious Diseases, 2006
In the context of tuberculosis (TB) resurgence, isoniazid preventive therapy (IPT) is increasingly promoted, but concerns about the risk for development of isoniazid-resistant tuberculosis may hinder its widespread implementation.
Maria Elvira Balcells, Sara L. Thomas, Peter Godfrey-Faussett, Alison D. Grant   +3 more
doaj   +2 more sources

Phenotypic low-level isoniazid resistance as a marker to predict ethionamide resistance in Mycobacterium tuberculosis [PDF]

International Journal of Mycobacteriology, 2017
Background: Tuberculosis is one of the most prevalent diseases in Pakistan. Pakistan has the highest burden of MDR-TB in the Eastern Mediterranean region. Ethionamide is an anti-tuberculous drug frequently used to treat MDR-TB.
Salima Qamar, Joveria Q Farooqi, Kausar Jabeen, Rumina Hasan   +3 more
doaj   +2 more sources

Prevalence and patterns of rifampicin and isoniazid resistance conferring mutations in Mycobacterium tuberculosis isolates from Uganda.

PLoS ONE, 2018
BackgroundAccurate diagnosis of tuberculosis, especially by using rapid molecular assays, can reduce transmission of drug resistant tuberculosis in communities.
Edgar Kigozi, George W Kasule, Kenneth Musisi, Deus Lukoye, Samuel Kyobe, Fred Ashaba Katabazi, Eddie M Wampande, Moses L Joloba, David Patrick Kateete   +8 more
doaj   +2 more sources

Transduction of Isoniazid Susceptibility-Resistance and Streptomycin Resistance in Mycobacteria [PDF]

Antimicrobial Agents and Chemotherapy, 1973
Transduction of resistance to isoniazid and streptomycin as well as susceptibility to isoniazid in Mycobacterium smegmatis SN2 has been demonstrated. A method has been described for the selection of isoniazid-susceptible variants after transduction of susceptibility.
Saroja, D, Gopinathan, KP
openaire   +3 more sources

High isoniazid resistance rates in rifampicin susceptible Mycobacterium tuberculosis pulmonary isolates from Pakistan. [PDF]

PLoS ONE, 2012
BackgroundRapid new diagnostic methods (including Xpert MTB/RIF assay) use rifampicin resistance as a surrogate marker for multidrug resistant tuberculosis. Patients infected with rifampicin susceptible strains are prescribed first line anti-tuberculosis
Naima Fasih, Yasraba Rafiq, Kausar Jabeen, Rumina Hasan   +3 more
doaj   +2 more sources

Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis

Nature Communications
Drug-resistant strains of Mycobacterium tuberculosis are a major global health problem. Resistance to the front-line antibiotic isoniazid is often associated with mutations in the katG-encoded bifunctional catalase-peroxidase.
XinYue Wang, William J. Jowsey, Chen-Yi Cheung, Caitlan J. Smart, Hannah R. Klaus, Noon EJ Seeto, Natalie JE Waller, Michael T. Chrisp, Amanda L. Peterson, Boatema Ofori-Anyinam, Emily Strong, Brunda Nijagal, Nicholas P. West, Jason H. Yang, Peter C. Fineran, Gregory M. Cook, Simon A. Jackson, Matthew B. McNeil   +17 more
doaj   +2 more sources

High-dose isoniazid for TB with low-to-moderate isoniazid resistance after 1 week of treatment. [PDF]

JAC Antimicrob Resist
To evaluate the effect of high-dose isoniazid in patients with isoniazid-resistant TB by its bactericidal activity after 1 or more weeks of treatment.Using the rapid direct method of phenotypic drug susceptibility testing, we screened persons with ...
Ranganathan UD, Smith-Jeffcoat SE, Balaji S, Devika K, Nair D, Devaleenal Daniel B, Srinivasan R, Baskaran M, RaviKumar D, Sangamithirai D, Radhika G, Mangalambal G, Lavanya J, Maheswaran K, Kumar S, Sridhar R, Tripathy S, Swaminathan S, Eisenach KD, Cegielski JP.   +19 more
europepmc   +2 more sources

Can resistance to either isoniazid or rifampicin predict multidrug resistance tuberculosis (MDR-TB)

Bulletin of the National Research Centre, 2023
Background Previous studies have shown significant differences and lack clarity on whether resistance to either isoniazid or rifampicin can predict multidrug resistance tuberculosis (MDR-TB).
Betty R. Mchaki, Fauster X. Mgaya, Peter P. Kunambi, Mecky I. Matee   +3 more
doaj   +1 more source

Drug-resistant Tuberculosis: First Line Drug Resistance Pattern among Mycobacterium Tuberculosis Strains Isolated from a Reference Laboratory in Kerala State, India

Journal of Pure and Applied Microbiology, 2021
Resistance to antimycobacterial agents consistently remains a major obstacle to end TB in India. Geographical prevalence data regarding drug-resistant evolutionary genetics of M. tuberculosis (MTB) remains sparse in India. Our objective was to determine
Neetha S Murthy, Sanjeev Nair, PK Ramya, Renu Susan George, B Ravikrishnan, M Sunil Kumar, Sairu Philip, PS Rakesh, Shibu Balakrishnan   +8 more
doaj   +1 more source

Isoniazid Resistance and the Future of Drug-Resistant Tuberculosis [PDF]

Microbial Drug Resistance, 2004
Bacterial chromosomal mutations that confer antibiotic resistance often have deleterious effects that impose costs on reproductive fitness. This observation has led to the generalization that in the absence of the selection pressure exerted through treatment, the frequency of resistance will decrease.
Ted, Cohen, Mercedes C, Becerra, Megan B, Murray   +2 more
openaire   +2 more sources