Results 41 to 50 of about 2,381,535 (223)

Isoniazid-resistant Tuberculosis in Children [PDF]

Pediatric Infectious Disease Journal, 2013
Isoniazid resistance is an obstacle to the treatment of tuberculosis disease and latent tuberculosis infection in children. We aim to summarize the literature describing the risk of isoniazid-resistant tuberculosis among children with tuberculosis disease.We did a systematic review of published reports of children with tuberculosis disease who had ...
Courtney M, Yuen, Arielle W, Tolman, Ted, Cohen, Jonathan B, Parr, Salmaan, Keshavjee, Mercedes C, Becerra   +5 more
openaire   +2 more sources

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Multivariate Analysis of Characteristics Associated with Isoniazid Mono-resistance.

, 2016
Multivariate Analysis of Characteristics Associated with Isoniazid Mono-resistance.
Patrick Van der Stuyft (154687), Leonela Villegas (2590909), Larissa Otero (308500), Timothy R. Sterling (148936), Eduardo Gotuzzo (20728), Carlos Seas (308510), Moises A. Huaman (2590906)   +6 more
core   +1 more source

Drug-resistance profile of Mycobacterium tuberculosis to first-line anti-tuberculosis agents in new and previously treated pulmonary tuberculosis patients from Andhra Pradesh, India

Journal of Clinical and Scientific Research
Background: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem. Methods: We tested 104 strains each of Mycobacterium tuberculosis complex (Mtb) isolated from new cases and previously treated cases against four first line anti ...
Anagoni Srikar, B. V. Ramana, P. V. G. K. Sarma, Alladi Mohan, Abhijit Chaudhury   +4 more
doaj   +1 more source

ISONIAZID - MONORESISTANT TUBERCULOSIS IN BULGARIA

Problems of Infectious and Parasitic Diseases, 2020
Background. Isoniazid is a common drug in the treatment regimens for TB infection. Monoisoniazid resistance reduces the probability of a successful treatment outcome and increases the risk of acquiring additional drug resistance. Material and methods.
Stanislava Yordanova, Ana Baykova, Yuliana Atanasova, Yana Todorova, Elizabeta Bachiyska   +4 more
doaj   +1 more source

Systematic Review of Females With Intellectual Disability and MECP2 Duplication

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT MECP2 Duplication Syndrome (MDS) is a rare, X‐linked neurodevelopmental disorder typically affecting males. Females with MDS have been reported and are compiled here. We conducted a systematic review (PROSPERO CRD420250652426) of PubMed, EMBASE, and Google Scholar extracting individual participant data.
Paul Malik, Davut Pehlivan, Cary Fu, Antonio F. Martinez‐Monseny, Mar O'Callaghan, Judith Armstrong, Sarika U. Peters, Steven T. Lee, Timothy J. Feyma, Paola Mian, Christine Coquery   +10 more
wiley   +1 more source

Explaining risk factors for drug-resistant tuberculosis in England and Wales: contribution of primary and secondary drug resistance [PDF]

, 2004
Drug-resistant tuberculosis can be transmitted (primary) or develop during the course of treatment (secondary). We investigated risk factors for each type of resistance.
Glynn, JR, Story, A, Hayward, AC, Watson, JM, Conaty, SJ, Drobniewski, FA   +5 more
core   +1 more source

Barriers in the implementation of isoniazid preventive therapy for people living with HIV in Northern Ethiopia: a mixed quantitative and qualitative study

BMC Public Health, 2016
Background Isoniazid preventive therapy is a key public health intervention for the prevention of tuberculosis disease among people living with HIV. Despite the confirmed efficacy of isoniazid preventive therapy and global recommendations existing for ...
Gebrehiwot Teklay, Tsigemariam Teklu, Befikadu Legesse, Kiros Tedla, Eveline Klinkenberg   +4 more
doaj   +1 more source

Identification of a mycobacterial hydrazidase, an isoniazid-hydrolyzing enzyme

Scientific Reports, 2023
There exists decades-old evidence that some mycobacteria, including Mycobacterium avium and Mycobacterium smegmatis, produce hydrazidase, an enzyme that can hydrolyze the first-line antitubercular agent isoniazid.
Arata Sakiyama, Chaogetu Saren, Yukihiro Kaneko, Ken-Ichi Oinuma   +3 more
doaj   +1 more source

The Blind Spot of GeneXpert MTB/RIF: Isoniazid-Resistant, Rifampicin-Susceptible Tuberculosis Detected on Phenotypic Drug Susceptibility Testing. [PDF]

Respirol Case Rep
GeneXpert MTB/RIF reports only rifampicin resistance, so a result of ‘rifampicin resistance not detected’ does not exclude isoniazid resistance. In this young man with hemoptysis and bilateral infiltrates, phenotypic drug susceptibility testing of bronchoalveolar lavage revealed isoniazid‐resistant, rifampicin‐susceptible tuberculosis after 1 month of ...
Nadeem HMF, Gohar A, Jakhar MF, Abbas R, Noor T, Ahmad MH.   +5 more
europepmc   +2 more sources