Results 101 to 110 of about 23,928 (250)

COCHLEATA controls spatial regulation of cytokinin and auxin during nodule development

open access: yesNew Phytologist, Volume 251, Issue 1, Page 228-244, July 2026.
Nodule development defects in the coch mutant include root‐like structures, reduced colonisation, and vascular disorganisation. Summary Root nodules host nitrogen‐fixing bacteria and likely evolved through modifications of the lateral root program. Members of the NOOT‐BOP‐COCH‐LIKE transcriptional coregulator family suppress root identity in nodules ...
Karen Velandia   +5 more
wiley   +1 more source

Isoprenoidquantifizierung in Hirngewebe - cerebrale Regulation von FPP und GGPP bei Morbus Alzheimer und im Alter

open access: yes, 2011
Over the last years there has been an increasing interest in the involvement of the MVA-pathway and of members of the small GTPases, in the development and progression of AD.
Hooff, Gero P.
core  

Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues

open access: yes, 2016
A set of synthetic approaches was developed and applied to the synthesis of eight frame-shifted isoprenoid diphosphate analogues. These analogues were designed to increase or decrease the methylene units between the double bonds and/or the pyrophosphate ...
Kayla J. Temple (3345344)   +3 more
core   +1 more source

Targeting of Staphyloxanthin and α‐Hemolysin by Natural Compound L‐Malic Acid Suppresses Staphylococcus aureus Virulence

open access: yesThe FASEB Journal, Volume 40, Issue 11, 15 June 2026.
L‐malic acid, a natural TCA cycle intermediate, attenuates the virulence of Staphylococcus aureus through dual metabolic and regulatory mechanisms. It redirects central carbon flux away from the mevalonate pathway and inhibits the key enzyme CrtO, suppressing staphyloxanthin biosynthesis and impairing bacterial resistance to oxidative stress ...
Li Shen   +11 more
wiley   +1 more source

A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics

open access: yesmSphere, 2019
Gram-negative bacteria in the order Rickettsiales have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever.
Vida Ahyong   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, Volume 600, Issue 11, Page 1621-1637, June 2026.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria

open access: yesFrontiers in Microbiology, 2012
Terpenoid metabolites are important to the cellular function, structural integrity, and pathogenesis of the human-specific pathogen Mycobacterium tuberculosis (Mtb).
Reuben J Peters   +3 more
doaj   +1 more source

Biosynthesis of Isoprenoid Precursors in Arabidopsis

open access: yes, 2012
Isoprenoids are the most functionally and structurally diverse group of plant metabolites reported to date. Many of them participate in essential processes, like respiration (ubiquinone), photosynthesis (carotenoids, chlorophylls, plastoquinone), and ...
Manuel Rodríguez-Concepción   +7 more
core   +1 more source

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

open access: yesAdvanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr   +9 more
wiley   +1 more source

Occurrence of squalene, di- and tetrahydrosqualenes, and vitamin MK8 in an extremely halophilic bacterium, Halobacterium cutirubrum

open access: yesJournal of Lipid Research, 1969
The nonpolar (acetone-soluble) lipids of the extremely halophilic bacterium, Halobacterium cutirubrum, were found to consist of red carotenoid pigments (43%) and squalenes (48%) with a small amount of a vitamin K-type quinone. The squalenes were shown by
T.G. Tornabene   +3 more
doaj   +1 more source

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