Two potentially bioactive fragments, namely a tricyclic quinazoline derivative with an exocyclic alkene moiety and a substituted isoquinoline, are coupled to give 3-{[6,7-dimethoxy-1-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]methylidene}-1,2,3,9-
Akmal Tojiboev +4 more
doaj +1 more source
Comparative study on the gas to solution phase solvation free energies of model combustion flue gas compounds (N~2~, O~2~, CO~2~, H~2~O, SO~2~, and CO) in 178 organic solvents using the IEFPCM-UFF, CPCM, and SMD implicit solvent models at the Gaussian-4 (G4) level of theory [PDF]
Gas to solution phase Gibbs free energies of solvation at 298.15 K for transfer of six representative combustion flue gas compounds (N~2~, O~2~, CO~2~, H~2~O, SO~2~, and CO) were calculated at the Gaussian-4 (G4) level of theory using the IEFPCM-UFF ...
Kaya Forest, Sierra Rayne
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Can Isoquinoline Alkaloids Affect Platelet Aggregation in Whole Human Blood?
Isoquinoline alkaloids have multiple biological activities, which might be associated with positive pharmacological effects as well as negative adverse reactions.
Mst Shamima Parvin +8 more
doaj +1 more source
A straightforward synthesis of indazolo[3,2-a]isoquinolin-6-amines [PDF]
4-Substituted 1-bromoisoquinolin-3-amines were subjected to Suzuki coupling with o-nitrophenylboronic acid to yield 1-(2-nitrophenyl) isoquinolinamines, which participated in Cadogan cyclization with triethyl phosphite under microwave irradiation in a ...
Balog, József +2 more
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2-Methylsulfanylbenzo[f]isoquinoline [PDF]
S-Methylation of a 4-(naphth-2-yl)-β-thiolactam gives an intermediate 4-(naphth-2-yl) substituted 1-azetine which undergoes a [2+2] ring-opening followed by electrocyclic ring closure of the resulting 2-azadiene to give a benzo[f ...
Hemming, Karl +2 more
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Synthesis of New β-enaminones of Isoquinolines with 5,5-dimethyl-cyclohexanedione
n ...
Stoyanka Nikolova, Iliyan Ivanov
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Two novel series of 3,4-dihydroisoquinolin with heterocycle derivatives (4a–t and 9a–e) were synthesized and evaluated for their anticonvulsant activity using maximal electroshock (MES) test and pentylenetetrazole (PTZ)-induced seizure test.
Hong-Jian Zhang +3 more
doaj +1 more source
Research Progress on Neuroprotective Effects of Isoquinoline Alkaloids
Neuronal injury and apoptosis are important causes of the occurrence and development of many neurodegenerative diseases, such as cerebral ischemia, Alzheimer’s disease, and Parkinson’s disease. Although the detailed mechanism of some diseases is unknown,
Jinhua Li +6 more
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We report a general strategy for meta‐selective C–H arylation using aryl iodides and a Pd(II)/Pd(IV) catalytic system guided by a removable directing group. DFT and experimental studies reveal that counter anion tuning (acetate to trifluoroacetate) significantly enhances selectivity.
Jagrit Grover +6 more
wiley +1 more source
Spectroscopic Properties of Polycyclic Aromatic Compounds. Examination of Nitromethane as a Selective Fluorescence Quenching Agent for Alternant Polycyclic Aromatic Nitrogen Hetero-Atom Derivatives [PDF]
Article on the spectroscopic properties of polycyclic aromatic compounds and an examination of nitromethane as a selective fluorescence quenching agent for alternant polycyclic aromatic nitrogen hetero-atom ...
Acree, William +5 more
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