Results 41 to 50 of about 40,846 (271)

Stereochemistry of the methylidene-bridged quinazoline-isoquinoline alkaloid 3-{[6,7-dimethoxy-1-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]methylidene}-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-9-one methanol monosolvate

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2020
Two potentially bioactive fragments, namely a tricyclic quinazoline derivative with an exocyclic alkene moiety and a substituted isoquinoline, are coupled to give 3-{[6,7-dimethoxy-1-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]methylidene}-1,2,3,9-
Akmal Tojiboev   +4 more
doaj   +1 more source

Comparative study on the gas to solution phase solvation free energies of model combustion flue gas compounds (N~2~, O~2~, CO~2~, H~2~O, SO~2~, and CO) in 178 organic solvents using the IEFPCM-UFF, CPCM, and SMD implicit solvent models at the Gaussian-4 (G4) level of theory [PDF]

open access: yes, 2010
Gas to solution phase Gibbs free energies of solvation at 298.15 K for transfer of six representative combustion flue gas compounds (N~2~, O~2~, CO~2~, H~2~O, SO~2~, and CO) were calculated at the Gaussian-4 (G4) level of theory using the IEFPCM-UFF ...
Kaya Forest, Sierra Rayne
core   +2 more sources

Can Isoquinoline Alkaloids Affect Platelet Aggregation in Whole Human Blood?

open access: yesToxins, 2022
Isoquinoline alkaloids have multiple biological activities, which might be associated with positive pharmacological effects as well as negative adverse reactions.
Mst Shamima Parvin   +8 more
doaj   +1 more source

A straightforward synthesis of indazolo[3,2-a]isoquinolin-6-amines [PDF]

open access: yes, 2013
4-Substituted 1-bromoisoquinolin-3-amines were subjected to Suzuki coupling with o-nitrophenylboronic acid to yield 1-(2-nitrophenyl) isoquinolinamines, which participated in Cadogan cyclization with triethyl phosphite under microwave irradiation in a ...
Balog, József   +2 more
core   +1 more source

2-Methylsulfanylbenzo[f]isoquinoline [PDF]

open access: yes, 2015
S-Methylation of a 4-(naphth-2-yl)-β-thiolactam gives an intermediate 4-(naphth-2-yl) substituted 1-azetine which undergoes a [2+2] ring-opening followed by electrocyclic ring closure of the resulting 2-azadiene to give a benzo[f ...
Hemming, Karl   +2 more
core   +2 more sources

Synthesis and Pharmacological Evaluation of New 3,4-Dihydroisoquinolin Derivatives Containing Heterocycle as Potential Anticonvulsant Agents

open access: yesMolecules, 2016
Two novel series of 3,4-dihydroisoquinolin with heterocycle derivatives (4a–t and 9a–e) were synthesized and evaluated for their anticonvulsant activity using maximal electroshock (MES) test and pentylenetetrazole (PTZ)-induced seizure test.
Hong-Jian Zhang   +3 more
doaj   +1 more source

Research Progress on Neuroprotective Effects of Isoquinoline Alkaloids

open access: yesMolecules, 2023
Neuronal injury and apoptosis are important causes of the occurrence and development of many neurodegenerative diseases, such as cerebral ischemia, Alzheimer’s disease, and Parkinson’s disease. Although the detailed mechanism of some diseases is unknown,
Jinhua Li   +6 more
doaj   +1 more source

A Generalized Approach for Distal C–H Arylation of Organic Building Blocks: Unveiling the Role of Counter Anion

open access: yesAdvanced Science, EarlyView.
We report a general strategy for meta‐selective C–H arylation using aryl iodides and a Pd(II)/Pd(IV) catalytic system guided by a removable directing group. DFT and experimental studies reveal that counter anion tuning (acetate to trifluoroacetate) significantly enhances selectivity.
Jagrit Grover   +6 more
wiley   +1 more source

Spectroscopic Properties of Polycyclic Aromatic Compounds. Examination of Nitromethane as a Selective Fluorescence Quenching Agent for Alternant Polycyclic Aromatic Nitrogen Hetero-Atom Derivatives [PDF]

open access: yes, 1992
Article on the spectroscopic properties of polycyclic aromatic compounds and an examination of nitromethane as a selective fluorescence quenching agent for alternant polycyclic aromatic nitrogen hetero-atom ...
Acree, William   +5 more
core   +1 more source

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