Results 11 to 20 of about 29,166 (317)
isoQUINOLINE DERIVATIVES. PART III [PDF]
, 1957 In contrast with the earlier observation (Ghosh and Dutta, this Journal, 1955, 32, 17, 755) that treatment of (a-acetamido-β-phenyl)-etbylmethyl ketone and of β-phenyl-substituted analogues with POCI3 or conc. H2SO4 leads to the formation of I-methylisoquinoline derivatives, accompanied with dehydrogenation and deacetylation, (α-scetamido-β-phenyl ...
T. N. GHOSH +2 more
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Recent Strategies in the Nucleophilic Dearomatization of Pyridines, Quinolines, and Isoquinolines [PDF]
Chem RevDearomatization reactions have become fundamental chemical transformations in organic synthesis since they allow for the generation of three-dimensional complexity from two-dimensional precursors, bridging arene feedstocks with alicyclic structures. When
Marcos Escolano +5 more
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Rh(III)-Catalyzed Double Annulation of 3-Phenyl-1,2,4-oxadiazoles with 2-Diazo-1,3-diketones: Access to Pyran-Fused Isoquinolines [PDF]
MoleculesEfficient access to pyranoisoquinoline derivatives via rhodium-catalyzed double C-H functionalization of phenyl oxadiazoles and diazo compounds has been developed.
Enshen Zhang, Mei Sun, Lvlv Gao
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Spasmolytic Activity of 1,3-Disubstituted 3,4-Dihydroisoquinolines [PDF]
BiomedicinesThis article concerns the spasmolytic activities of some novel 1,3-disubstituted 3,4-dihydroisoquinolines. These compounds can be evaluated as potential therapeutic candidates according to Lipinski’s rule of five, showing high gastrointestinal absorption
Miglena Milusheva +5 more
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Synthesis of spiroindolenines through a one-pot multistep process mediated by visible light [PDF]
Beilstein Journal of Organic ChemistrySpiro-heterocyclic indolenines are privileged scaffolds widely present in numerous indole alkaloids. Here, we develop a novel approach for the one-pot multistep synthesis of different spiro[indole-isoquinolines].
Francesco Gambuti +4 more
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Pyridine-based strategies towards nitrogen isotope exchange and multiple isotope incorporation [PDF]
Nature CommunicationsIsotopic labeling is at the core of health and life science applications such as nuclear imaging, metabolomics and plays a central role in drug development. The rapid access to isotopically labeled organic molecules is a sine qua non condition to support
Minghao Feng +9 more
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C-1 Substituted isoquinolines potentiate the antimycobacterial activity of rifampicin and ethambutol
Frontiers in Antibiotics, 2023 IntroductionThe emergence of extensively drug-resistant strains of Mycobacterium tuberculosis threatens decades of progress in the treatment of a disease which remains one of the leading infectious causes of death worldwide.
Liam T. Martin +9 more
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A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B
Molecules, 2022 Recent reports of antiepileptic activity of the fungal alkaloid TMC-120B have renewed the interest in this natural product. Previous total syntheses of TMC-120B comprise many steps and have low overall yields (11–17 steps, 1.5–2.9% yield).
Ahmad K. Haidar +6 more
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Molecules, 2023 An innovative and efficient approach has been developed for the synthesis of 5,6-dihydropyrazolo[5,1-a]isoquinolines. This one-pot tandem reaction involves the reaction of C,N-cyclic azomethine imines with α,β-unsaturated ketones, using K2CO3 as the base
Young Jae Yun, Sung-Gon Kim
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The Anticancer Effect of Natural Plant Alkaloid Isoquinolines
International Journal of Molecular Sciences, 2021 Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apoptosis, and autophagy, leading to cell death.
Dahye Yun, S. Yoon, S. Park, Y. Park
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