Effects of a Synthetic Isoquinoline Derivative Against Ichthyophthirius multifiliis In Vivo and In Vitro in Grass Carp (Ctenopharyngodon idella) [PDF]
PathogensWhite spot disease, caused by the parasitic Ichthyophthirius multifiliis, induces mortality exceeding 80% in intensive aquaculture systems, resulting in global annual losses of >$1 billion.
Xianqi Peng +11 more
doaj +2 more sources
Photoredox catalytic asymmetric dearomative [3 + 2] cycloaddition of isoquinolines with enones [PDF]
Nature CommunicationsAsymmetric dearomative photocycloaddition has emerged as a transformative strategy for the enantioselective construction of complex three-dimensional molecular architectures from simple planar aromatic precursors. While significant progress has been made
Jingjing Huo +5 more
doaj +2 more sources
Rh(III)-Catalyzed Double Annulation of 3-Phenyl-1,2,4-oxadiazoles with 2-Diazo-1,3-diketones: Access to Pyran-Fused Isoquinolines [PDF]
MoleculesEfficient access to pyranoisoquinoline derivatives via rhodium-catalyzed double C-H functionalization of phenyl oxadiazoles and diazo compounds has been developed.
Enshen Zhang, Mei Sun, Lvlv Gao
doaj +2 more sources
C-1 Substituted isoquinolines potentiate the antimycobacterial activity of rifampicin and ethambutol
Frontiers in Antibiotics, 2023 IntroductionThe emergence of extensively drug-resistant strains of Mycobacterium tuberculosis threatens decades of progress in the treatment of a disease which remains one of the leading infectious causes of death worldwide.
Liam T. Martin +9 more
doaj +1 more source
A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B
Molecules, 2022 Recent reports of antiepileptic activity of the fungal alkaloid TMC-120B have renewed the interest in this natural product. Previous total syntheses of TMC-120B comprise many steps and have low overall yields (11–17 steps, 1.5–2.9% yield).
Ahmad K. Haidar +6 more
doaj +1 more source
Molecules, 2023 An innovative and efficient approach has been developed for the synthesis of 5,6-dihydropyrazolo[5,1-a]isoquinolines. This one-pot tandem reaction involves the reaction of C,N-cyclic azomethine imines with α,β-unsaturated ketones, using K2CO3 as the base
Young Jae Yun, Sung-Gon Kim
doaj +1 more source
Molecules, 2021 Publications covering a new easy metal-free functionalization of pyridinoids (pyridines, quinolines, isoquinolines, acridine) under the action of the system of electron-deficient acetylenes (acetylenecarboxylic acid esters, acylacetylenes)/P-nucleophiles
Boris A. Trofimov +2 more
doaj +1 more source
Silver-Mediated Electrosynthesis of Substituted Isoquinolines via Cyclization of 2‑Ethynylbenzaldehydes [PDF]
ACS OmegaEliakin S. de Borba +7 more
doaj +2 more sources
Synthesis of spiroindolenines through a one-pot multistep process mediated by visible light [PDF]
Beilstein Journal of Organic ChemistrySpiro-heterocyclic indolenines are privileged scaffolds widely present in numerous indole alkaloids. Here, we develop a novel approach for the one-pot multistep synthesis of different spiro[indole-isoquinolines].
Francesco Gambuti +4 more
doaj +2 more sources
Recent Advances in the Synthesis of Isoquinoline-Fused Benzimidazoles
Molecules, 2022 This review includes recent developments in the synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines with particular attention given to categorizing protocols based on the structural features of the ring architecture and crystallographically characterized ...
Dylan J. Twardy +3 more
doaj +1 more source