Results 21 to 30 of about 16,127 (272)

The unique reactivity of 5,6-unsubstituted 1,4-dihydropyridine in the Huisgen 1,4-diploar cycloaddition and formal [2 + 2] cycloaddition

Beilstein Journal of Organic Chemistry, 2023
The three-component reaction of isoquinolines, dialkyl acetylenedicarboxylates, and 5,6-unsubstituted 1,4-dihydropyridines in acetonitrile at room temperature afforded functionalized isoquinolino[1,2-f][1,6]naphthyridines in good yields and with high ...
Xiu-Yu Chen, Hui Zheng, Ying Han, Jing Sun, Chao-Guo Yan   +4 more
doaj   +1 more source

Facile Synthesis of Tricyclic 1,2,4-Oxadiazolines-Fused Tetrahydro-Isoquinolines from Oxime Chlorides with 3,4-Dihydroisoquinoline Imines

Molecules, 2022
A mild and efficient strategy for the synthesis of tricyclic 1,2,4-oxadiazolines-fused tetrahydro-isoquinolines derivatives via [3 + 2] cycloaddition reaction is reported.
Kaikai Wang, Yanli Li, Wei Zhang, Rongxiang Chen, Xueji Ma, Mingyue Wang, Nan Zhou   +6 more
doaj   +1 more source

1,3-Dipolar cycloadditions of azomethine imines [PDF]

, 2015
Azomethine imines are considered 1,3-dipoles of the aza-allyl type which are transient intermediates and should be generated in situ but can also be stable and isolable compounds.
Nájera, Carmen, Sansano, Jose M., Yus, Miguel   +2 more
core   +3 more sources

‘One-pot’ Synthesis of Dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a Silver(I)-Catalyzed Cascade Approach

Molecules, 2013
An efficient approach for the synthesis of biologically interesting fused tetracyclic isoquinolines in high yields and with a broad substrate scope has been developed. The strategy features an AgNO3 catalyzed ‘one-pot’ cascade process
Jian Li, Hong Liu, Qingya Kong, Hualiang Jiang, Yu Zhou, Baifeng Jiang   +5 more
doaj   +1 more source

Hypecoum spp.—Chemistry and Biological Activity of Alkaloids

Diversity, 2023
Genus Hypecoum Tourn. ex L. belongs to the poppy family Papaveraceae and comprises about 19 species occurring in Europe, Northern Africa and Asia.
Nadezhda Kostova, Tsvetelina Doncheva
doaj   +1 more source

Visible-light photoredox catalyzed synthesis of pyrroloisoquinolines via organocatalytic oxidation/[3 + 2] cycloaddition/oxidative aromatization reaction cascade with Rose Bengal [PDF]

, 2014
Pyrrolo[2,1-a]isoquinoline alkaloids have been prepared via a visible light photoredox catalyzed oxidation/[3 + 2] cycloaddition/oxidative aromatization cascade using Rose Bengal as an organo-photocatalyst.
Lau, Jonathan, Rueping, Magnus, Vila Descals, Carlos   +2 more
core   +3 more sources

A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy

Beilstein Journal of Organic Chemistry, 2017
Diversity-oriented synthesis of the biologically intriguing imidazo[1,2-a]pyridine-fused isoquinoline systems from readily available starting materials was achieved through the Groebke–Blackburn–Bienaymé reaction followed by a gold-catalyzed cyclization ...
Taofeng Shao, Zhiming Gong, Tianyi Su, Wei Hao, Chao Che   +4 more
doaj   +1 more source

7-Acetyl-8-(4-chlorophenyl)-3-ethylsulfanyl-6-hydroxy-1,6-dimethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

IUCrData, 2017
In the title compound, C22H23ClN2O2S, the chlorophenyl ring is inclined to the pyridine ring of the isoquinoline ring system by 79.78 (4)°. The cyclohexane ring adopts a flattened boat conformation.
Joel T. Mague, Shaaban K. Mohamed, Mehmet Akkurt, Etify A. Bakhite, Mustafa R. Albayati   +4 more
doaj   +1 more source

A Facile Palladium Catalysed 3-Component Cascade Route to Functionalised Isoquinolinones and Isoquinolines [PDF]

, 2016
Palladium catalysed three component cascade process, involving coupling of 2-iodobenzoates, -benzaldehydes, or acetophenones with substituted allenes and ammonium tartrate as an ammonium surrogate, provides a novel and facile route to substituted ...
Ackermann, Asano, Boonsong Kongkathip, Chen, Chiarugi, Chou, Chrzanowska, Chueh, Colin W. G. Fishwick, Diederen, Dondas, Elghareeb E. Elboray, Fujiwara, Gai, Gai, Gardiner, Goralski, Grigg, Grigg, Grigg, Grigg, Grigg, Grigg, Groome, Guimond, H. Ali Dondas, Hussien H. Abbas-Temirek, Ingrassia, Iwasa, Jayaraman, Kuo, Larock, Lechel, Lee, Lu, Matveenko, Moustafa F. Aly, Ngampong Kongkathip, Nutthawat Chuanopparat, Ochi, Padwa, Pellicciari, Ronald Grigg, Scott, Sunisa Akkarasamiyo, Too, Wang, Xiao, Yamauchi, Zeni, Álvarez, Álvarez   +51 more
core   +1 more source

Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]isoquinolines

Molecules, 2022
A new series of pyrazolo[3,4-g]isoquinoline derivatives, diversely substituted at the 4- or 8-position, were synthesized. The results of the kinase inhibitory potency study demonstrated that the introduction of a bromine atom at the 8-position was ...
Mathilde Defois, Chloé Rémondin, Béatrice Josselin, Lionel Nauton, Vincent Théry, Fabrice Anizon, Sandrine Ruchaud, Francis Giraud, Pascale Moreau   +8 more
doaj   +1 more source