Results 71 to 80 of about 15,657 (274)

Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]

, 2013
Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Amann, Kerstin, Babelova, Andrea, Brandes, Ralf Peter Louis, Daniel, Christoph, Fork, Christian, Jansen, Felix, Jung, Oliver, Löhn, Matthias, Pavenstädt, Hermann, Plettenburg, Oliver, Ruetten, Hartmut, Sander, Kerstin, Schäfer, Liliana, Stark, Holger   +13 more
core   +3 more sources

Photocatalytic Hydrogenation of Quinolines to Form 1,2,3,4‐Tetrahdyroquinolines Using Water as the Hydrogen Atom Donor

Angewandte Chemie International Edition, EarlyView.
A sequential process combining hydrogenation and a subsequent stereomutation is presented for trans selective hydrogenation of quinolines using water as the hydrogen atom source. Mechanistic studies reveal that the hydrogenation proceeds through a cascade process comprising an initial cis selective photocatalytic hydrogenation of the heteroarene core ...
Jingjing Zhang, Nico Spreckelmeyer, Jessika Lammert, Maxim‐Aleksa Wiethoff, Matthew James Milner, Christian Mück‐Lichtenfeld, Armido Studer   +6 more
wiley   +1 more source

The Cyclisation of l-Aryl-2-Benzamidoalkan-l-Ols to 4,5-DihydroOxazoles or Isoquinolines [PDF]

, 1990
The cyclisation of several N-benzoyl derivatives of 2-amino-l-phenylpropan-l-ol w~e carried out employing the Pictet-Cams modification ofthe BischlerNapieralski reaction. The formation of4, 5-dihydro-oxazoles orisoquinolines depends on the substituents
Md. Sharif, Atan, O. Fitton, Alan
core  

Intramolecular cyclization of b,b-difluorostyrenes bearing an iminomethyl or a diazenyl group at the ortho position: synthesis of 3-fluorinated isoquinoline and cinnoline derivatives [PDF]

, 2007
journal ...
ICHIKAWA Junji, Kuroki Hiroyuki, Mihara Jun, Nadano Ryo, Wada Yukinori   +4 more
core   +1 more source

Synthesis of Dihydroindoloisoquinolines through Copper‐Catalyzed Cross‐Dehydrogenative Coupling of Tetrahydroisoquinolines and Nitroalkanes [PDF]

, 2018
Lately, the cross‐dehydrogenative coupling of tetrahydroisoquinolines and nitroalkanes has become a widely studied reaction in organic chemistry; the corresponding β‐nitroamines are generally formed irrespective of the catalysis and activation mode ...
Allen, Alonso, Baslé, Baslé, Blakemore, Chen, Condie, Eastman, Faust, Gawande, Girard, Goldbrunner, Hirano, Jia-Lei, Li, Li, Liu, Minato, Mitrofanov, Nie, Noble, Polossek, Prat, Ratnikov, Rueping, Rusch, Samanta, Shu, Su, Tsang, Wang, Wang, Wang, Wei, Xie, Xie, Yang, Yang, Yu, Yuan, Zhang, Zhang   +41 more
core   +2 more sources

Hysteresis Photomodulation within Photochromic Assemblies of [Dy(Tp2−py)F]+ Single‐Molecule Magnets : Influence of the Supramolecular Magnetic Couplings.

Chemistry – A European Journal, Volume 31, Issue 16, March 17, 2025.
Several assemblies of Dysprosium based SMMs with photochromic ligands featuring full photoconversion of the ligands within single crystals are reported. Magnetic slow relaxation as well as magnetic hysteresis are observed and can be both modulated upon light irradiation.
Nour El Beyrouti, Felix Houard, Francisco Javier Valverde‐Muñoz, Louis Caussin, Maher Hojorat, Marie Cordier, Elzbieta Trzop, Stéphane Rigaut, Boris Le Guennic, Kévin Bernot, Lucie Norel   +10 more
wiley   +1 more source

Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010

Molecules, 2011
Many natural substances with proven anti-inflammatory activity have been isolated throughout the years. The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010.
Margareth de Fátima Formiga Melo Diniz, José Maria Barbosa Filho, Petrônio Filgueiras de Athayde-Filho, Marcelo Sobral da Silva, Josean Fechine Tavares, Augusto Lopes Souto   +5 more
doaj   +1 more source

Fused Nitrogen Bridgehead N,O‐Acetals as Versatile Scaffolds: Synthetic Strategies, Mechanism and Applications

Chemistry – A European Journal, EarlyView.
Fused nitrogen‐bridgehead N,O‐acetals receive specific emphasis as pivotal scaffolds due to their significant role in the bioactivity of medicinally relevant molecules. Significant approaches have been reported on their role as key synthetic building blocks/motifs in the construction of complex organic molecules and their utility as chiral auxiliaries ...
Alexis D. Kouvelas, Michael G. Kallitsakis, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Molecular geometry of alkaloids present in seeds of mexican prickly poppy [PDF]

arXiv, 2015
The work is a study of the geometry of the molecules via molecular mechanics of the main alkaloids found in the seeds of Argemone Mexicana Linn, a prickly poppy, which is considered one of the most important species of plants in traditional Mexican and Indian medicine system.
arxiv  

Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis

Chemistry – A European Journal, EarlyView.
This review highlights recent advances in mechanochemical methods for multistep organic synthesis, focusing on sequential one‐pot approaches performed by grinding or ball milling. The presented transformations are discussed in terms of efficiency, applicability, and sustainability, assessing both the challenges and potential of solvent‐free one‐pot ...
Nina Biedermann, Michael Schnürch
wiley   +1 more source