Results 81 to 90 of about 15,657 (274)

N-formylation of isoquinoline derivatives with CO2 and H2 over a heterogeneous Ru/ZIF-8 catalyst

Journal of Experimental Nanoscience, 2022
Chemical utilization of CO2 is one of the fundamental strategies to synthesize value-added chemicals and reduce the CO2 emission. N-formyl-1,2,3,4-tetrahydroisoquinoline derivatives (FTHIQs) are important chemicals for the synthesis of medical ...
Zhen-Hong He, Yuan-Yuan Wei, Na Li, Yong-Chang Sun, Shao-Yan Yang, Kuan Wang, Weitao Wang, Xiaoxue Ma, Zhao-Tie Liu   +8 more
doaj   +1 more source

Is ESA Relationship The Tool In Searching For Interstellar Heterocycles? [PDF]

arXiv, 2019
Because of their importance in biological systems, in our understanding of the solar system and in other applications, seven heterocycles; furan, imidazole, pyridine, pyrimidine, pyrrole, quinoline and isoquinoline have been astronomically searched for in different molecular clouds with only the upper limits in the range of 4*1012 to 2.8*1021cm-2 ...
arxiv  

Computational Exploration of Stereoelectronic Relationships in Manganese‐Catalyzed Hydrogenation Reactions

Chemistry – A European Journal, EarlyView.
A detailed computational investigation of stereoelectronic effects in enantioselective manganese‐catalyzed hydrogenation reactions uncovered two general routes to improved selectivity; namely extension of π‐system and increased steric bulk (quantified through occupied volume in quadrants). Electronic effects were evaluated through Hammett correlations,
Alister S. Goodfellow, Matthew L. Clarke, Michael Bühl   +2 more
wiley   +1 more source

Minisci Reaction by an MW‐Boost: A Simple Protocol for Site‐Selective Dehydrogenative Cross‐Coupling Between Nitrogen‐Aromatics and C(sp3)─H Bonds

Chemistry – A European Journal, EarlyView.
The Minisci‐type cross‐coupling reaction between C─(sp3)─H bonds and nitrogen‐containing aromatics proceeded successfully using a simple protocol based on MW (microwave) irradiation with a persulfate anion. The MW/PS protocol is applicable to a wide variety of dehydrogenative cross‐coupling leading to the formation of alkylated heteroaromatics, in ...
Syuan‐Ping Jou, Yen‐Ku Wu, Takahide Fukuyama, Saki Fujii, Ilhyong Ryu   +4 more
wiley   +1 more source

Small molecule SARM1 inhibitors recapitulate the SARM1 -/- phenotype and allow recovery of a metastable pool of axons fated to degenerate [PDF]

, 2021
Axonal degeneration is responsible for disease progression and accumulation of disability in many neurodegenerative conditions. The axonal degenerative process can generate a metastable pool of damaged axons that remain structurally and functionally ...
Bosanac, Todd, Devraj, Rajesh, DiAntonio, Aaron, Engber, Thomas M, Hughes, Robert O, Krauss, Raul, Mao, Xianrong, Milbrandt, Jeffrey   +7 more
core   +1 more source

Oxidative Dehydrogenation of N‐Heteroaromatic Alkyl Alcohols and Amines Facilitated by Dearomative Tautomerization

Chemistry – A European Journal, Accepted Article.
The oxidation of alcohols, amines, and halides is a fundamental transformation in organic chemistry with significant applications in the synthesis of fine chemicals, pharmaceuticals, and natural products. Here we show that a broad variety of N‐heteroarenes bearing hydroxymethyl, aminomethyl, or halomethyl groups are oxidatively dehydrogenated to their ...
Omid Ghasemloo, Carson L. Hasselbrink, Douglas D. Cardona, Brenton DeBoef, Dugan Hayes   +4 more
wiley   +1 more source

Inhibitors of the Detoxifying Enzyme of the Phytoalexin Brassinin Based on Quinoline and Isoquinoline Scaffolds

Molecules, 2017
The detoxification of the phytoalexin brassinin to indole-3-carboxaldehyde and S-methyl dithiocarbamate is catalyzed by brassinin oxidase (BOLm), an inducible fungal enzyme produced by the plant pathogen Leptosphaeria maculans.
M. Soledade C. Pedras, Abbas Abdoli, Vijay K. Sarma-Mamillapalle   +2 more
doaj   +1 more source

Synthesis of Polysubstituted 3-Methylisoquinolines through the 6π-Electron Cyclization/Elimination of 1-Azatrienes derived from 1,1-Dimethylhydrazine [PDF]

, 2018
A convenient one pot microwave-assisted 6π-electron cyclization/aromatization approach toward 3-methylisoquinolines is reported. The starting 1-azatriene derivatives were prepared in situ by reaction of 2-propenylbenzaldehydes with 1,1-dimethylhydrazine,
Alonso, Alvarez-Builla, Antkiewicz-Michaluk, Austin, Blunt, Bräse, Chan, Choshi, Chu, Clayton, Coppola, Fujita, Gilchrist, Gilchrist, Gilchrist, Gilmore, Govindachari, Govindachari, Hanessian, Hibino, Hibino, Ishihara, Jiang, Kobayashi, Kohno, Kumemura, Kumemura, Kuwabara, Kwon, Li, Loones, Lyaskovskyy, Maekawa, Markey, Maul, Maynard, McBurney, McNab, McNab, Meegalla, Meketa, Meng, Müller, Neumeyer, Ogawa, Olsen, Omura, Ono, Ono, Palacios, Parthasarathy, Parthasarathy, Patel, Phillipson, Potts, Pérez, Resende, Resende, Sakaguchi, Shaban, Sklenicka, Staben, Sureshbabu, Tanaka, Tanaka, Tejedor, Trost, Umetsu, Vargas, Vincze, Wagner, Wahyuningsih, Wróbel, Zhao, Zhao, Zielinski   +75 more
core   +1 more source

Insights into the Structure–Property Relationship of Difluoro Boron Dipyridomethene Derivatives

ChemPhotoChem, EarlyView.
A large panel of electron‐donating and electron‐withdrawing groups are introduced on the meso, 3 and/or 7 position of the BF2‐DIPYR core. New mono‐, bis‐, and tris‐substituted fluorescent difluoro dipyridomethene boron complexes are synthetized. X‐ray diffraction analysis, spectroscopic studies, and theoretical calculations allow a detailed structure ...
Camille Chériaux, Thomas V. Papineau, Pascal Retailleau, Carlotta Figliola, Denis Jacquemin, Gilles Ulrich   +5 more
wiley   +1 more source

Synthesis of Some Novel 11b-Substituted Pyrimido[6,1-a]-isoquinoline Derivatives

Molecules, 2004
A series of novel 11b-substituted 1,6,7,11b-tetrahydropyrimido[6,1-a]- isoquinoline-2,4-diones and 4-thioxo-1,3,4,6,7,11b-hexahydropyrimido[6,1-a]isoquinolin-2- ones were synthesized, utilizing two alternative strategies for ring closure of ...
Atanas P. Venkov, Iliyan I. Ivanov, Plamen A. Angelov   +2 more
doaj   +1 more source