Results 71 to 80 of about 190,436 (297)

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review

Applied Sciences
The health-promoting, preventive, protective, and therapeutic applications of the natural compound sulforaphane (SF) produced from its biogenic precursor in broccoli, glucoraphanin, are extremely well established.
Jed W. Fahey, Mirran Raphaely
doaj   +1 more source

The rapid generation of isothiocyanates in flow

Beilstein Journal of Organic Chemistry, 2013
Isothiocyanates are versatile starting materials for a wide range of chemical reactions. However, their high nucleophilic susceptibility means they are best prepared and used immediately.
Marcus Baumann, Ian R. Baxendale
doaj   +1 more source

Synthesis, Diagnoses and Biological Evaluation of New Ligand Derived from Mesalazine and acetyl isothiocyanate with their metal ion complexes [PDF]

Journal of Bioscience and Applied Research
Mesalazine ligand (ML) having the isothiocyanate has been synthesis via reaction of mesalazine with acetyl isothiocyanate using absolute ethanol to give 5-(3-acetylthioureido)-2-hydroxybenzoic acid (ML) ligand in one step, then the two step involved the ...
Muhammed A. Hasan Shallal, Athmar A.Kadhim, Hayfa A. Mubarak, Huda Hadi Nameh   +3 more
doaj   +1 more source

Diverted Natural Lossen-type Rearrangement for Bioconjugation through in Situ Myrosinase-Triggered Isothiocyanate Synthesis

, 2019
Fluorescein isothiocyanate (FITC) is one of the most extensively used fluorescent probes for the labeling of biomolecules. The isothiocyanate function reacts with lysine residues of proteins to provide a chemically stable thiourea linkage without ...
Marie Hubert-Roux, Renard, Pierre-Yves, Gandolfo, Pierrick, Giuliano Cutolo (6593273), Pierrick Gandolfo, Cutolo, Giuliano, Tatibouët, Arnaud, Poret, Benjamin, Arnaud Tatibouët (6593282), Pierre-Yves Renard, Sabot, Cyrille, Castel, Hélène, Marie Schuler (2347831), Reine Nehmé (6593279), Jean Wilfried Fredy (3769150), Cyrille Sabot (1724836), Pierre-Yves Renard (1679626), Jean Wilfried Fredy, Reine Nehmé, Arnaud Tatibouët, Pierrick Gandolfo (167398), Hélène Castel, Giuliano Cutolo, Nehmé, Reine, Marie Schuler, Benjamin Poret, Fredy, Jean Wilfried, Schuler, Marie, Marie Hubert-Roux (1468372), Cyrille Sabot, Hubert-Roux, Marie, Hélène Castel (1724824), Benjamin Poret (6593276)   +32 more
core   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

α-Cyclodextrin/Moringin Induces an Antioxidant Transcriptional Response Activating Nrf2 in Differentiated NSC-34 Motor Neurons

Antioxidants
Oxidative stress is a common feature of neurodegenerative diseases. Different natural compounds mediate neuroprotective effects by activating the Nrf2 antioxidant response. Some isothiocyanates are Nrf2 activators, including Moringin (MOR). In this study,
Agnese Gugliandolo, Gabriella Calì, Claudia Muscarà, Osvaldo Artimagnella, Patrick Rollin, Daniele Perenzoni, Renato Iori, Emanuela Mazzon, Luigi Chiricosta   +8 more
doaj   +1 more source

Biofumigation for Fighting Replant Disease- A Review

Agronomy, 2020
Replant disease is a soil (micro-) biome-based, harmfully-disturbed physiological and morphological reaction of plants to replanting similar cultures on the same sites by demonstrating growth retardation and leading to economic losses especially in ...
Franziska S. Hanschen, Traud Winkelmann
doaj   +1 more source

Phenyl Isothiocyanate

, 2017
Cyclization Reactions. Phenyl isothiocyanate with 2- aminopyridine in the presence of iodine (0.2 equiv) with no solvent (neat) at room temperature gave the corresponding N-fused 1,2,4-thiadiazoles in excellent ...
Сливка, Михайло Васильович, Король, Наталія Іванівна   +1 more
core  

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source