Results 1 to 10 of about 23,093 (215)

Analysis of musculoskeletal side effects of oral Isotretinoin treatment: a cross-sectional study [PDF]

BMC Musculoskeletal Disorders, 2020
Background/ objectives Acne vulgaris is a chronic inflammatory disease affecting the pilosebaceous unit. Isotretinoin is an effective treatment option for severe acne.
Nermin Karaosmanoğlu, Cevriye Mülkoğlu   +1 more
openalex   +2 more sources

The rates of major malformations after gestational exposure to isotretinoin: a systematic review and meta-analysis [PDF]

Obstetrics & Gynecology Science, 2021
Objective Isotretinoin is among the most notorious human teratogens, documented originally as causing up to 30% of malformations. This systematic review and meta-analysis aimed to evaluate the rates of major malformation (MM) among isotretinoin-exposed ...
Eun Jeong Choi, NaeRy Kim, Ho-Seok Kwak, Hae Ji Han, Kyoung-Chul Chun, Young-Ah Kim, Jae-Whoan Koh, Jung Yeol Han, Sung Hong Joo, Ji Sung Lee, Gideon Koren   +10 more
doaj   +2 more sources

Clinical features, treatment, and outcome of isotretinoin-associated sacroiliitis. [PDF]

Arthritis Res Ther
Background Sacroiliitis is a rare adverse reaction of isotretinoin. However, the data on the clinical features, treatment and outcomes of isotretinoin-associated sacroiliitis are limited.
Zhao S, Sun W, Peng L, Wang C.
europepmc   +2 more sources

Isotretinoin in Thick-Skin Rhinoplasty: A Review. [PDF]

Int Arch Otorhinolaryngol
Dias RPP, Rodrigues JLT, Jabour MSD, Albuquerque ROE, Friedrich HA, Westphalen MS, Caropreso CA.   +6 more
europepmc   +3 more sources

Oral Isotretinoin and Its Uses in Dermatology: A Review

Drug Design, Development and Therapy, 2023
In 1982, the Food and Drug Administration (FDA) of the United States of America approved isotretinoin (13-cis-retinoic acid), a retinoid derivative of vitamin A, to treat severe recalcitrant acne vulgaris.
A. Paichitrojjana, Anand Paichitrojjana
semanticscholar   +1 more source

Community pharmacists’ knowledge and awareness about isotretinoin therapy and its dispensing practice in Jordan

Heliyon, 2023
A validated self-reported questionnaire was used to evaluate pharmacists' knowledge about isotretinoin and their awareness of isotretinoin dispensing practice.
Anan S. Jarab, Sayer I. Al-Azzam, Shriefa Al-Mutairi, Shrouq Abu Heshmeh, Tareq L. Mukattash, Walid AL-Qerem, Rami Beiram, Salah Aburuz   +7 more
doaj   +1 more source

Acne Transcriptomics: Fundamentals of Acne Pathogenesis and Isotretinoin Treatment

Cells, 2023
This review on acne transcriptomics allows for deeper insights into the pathogenesis of acne and isotretinoin’s mode of action. Puberty-induced insulin-like growth factor 1 (IGF-1), insulin and androgen signaling activate the kinase AKT and mechanistic ...
Bodo C Melnik
semanticscholar   +1 more source

Risk of Suicide and Psychiatric Disorders Among Isotretinoin Users

JAMA dermatology, 2023
Key Points Question Is isotretinoin use associated with the risk of suicide and psychiatric disorders? Findings In this meta-analysis of 25 studies including 1 625 891 participants, the 1-year absolute risk of completed suicide, suicide attempt, suicide ...
N. Tan, Adelina Tang, Neil Chen Yi Lun MacAlevey, Benjamin Kye Jyn Tan, H. Oon   +4 more
semanticscholar   +1 more source

Treatment response to isotretinoin correlates with specific shifts in Cutibacterium acnes strain composition within the follicular microbiome

Experimental Dermatology, 2023
There are no drugs as effective as isotretinoin for acne. Deciphering the changes in the microbiome induced by isotretinoin in the pilosebaceous follicle of successfully treated patients can pave the way to identify novel therapeutic alternatives.
Z. Nolan, K. Banerjee, Z. Cong, S. L. Gettle, A. Longenecker, Y. Kawasawa, A. Zaenglein, D. Thiboutot, G. Agak, X. Zhan, A. Nelson   +10 more
semanticscholar   +1 more source

Dendrimer-conjugated isotretinoin for controlled transdermal drug delivery

Journal of Nanobiotechnology, 2023
Background In the present study, we aimed to develop a novel isotretinoin delivery model for treating skin diseases, revealing its potential advantages in drug delivery and targeted therapy.
Tianqi Zhao, Mingwei Zhou, Ronghui Wu, Huaxin Wang, C. Zouboulis, Mingji Zhu, Myongsoo Lee   +6 more
semanticscholar   +1 more source