Results 11 to 20 of about 33,366 (300)
The rates of major malformations after gestational exposure to isotretinoin: a systematic review and meta-analysis [PDF]
Obstetrics & Gynecology Science, 2021 Objective Isotretinoin is among the most notorious human teratogens, documented originally as causing up to 30% of malformations. This systematic review and meta-analysis aimed to evaluate the rates of major malformation (MM) among isotretinoin-exposed ...
Eun Jeong Choi +10 more
doaj +2 more sources
Isotretinoin and adverse neuropsychiatric outcomes: retrospective cohort study using routine data* [PDF]
British Journal of Dermatology, 2022 Severe neuropsychiatric outcomes have been reported in individuals exposed to isotretinoin, but the evidence is inconclusive and complicated by several methodological limitations.
Tapio Paljärvi +4 more
openalex +2 more sources
Oral Isotretinoin and Its Uses in Dermatology: A Review
Drug Design, Development and Therapy, 2023 In 1982, the Food and Drug Administration (FDA) of the United States of America approved isotretinoin (13-cis-retinoic acid), a retinoid derivative of vitamin A, to treat severe recalcitrant acne vulgaris.
A. Paichitrojjana, Anand Paichitrojjana
semanticscholar +1 more source
Acne Transcriptomics: Fundamentals of Acne Pathogenesis and Isotretinoin Treatment
Cells, 2023 This review on acne transcriptomics allows for deeper insights into the pathogenesis of acne and isotretinoin’s mode of action. Puberty-induced insulin-like growth factor 1 (IGF-1), insulin and androgen signaling activate the kinase AKT and mechanistic ...
Bodo C Melnik
semanticscholar +1 more source
Risk of Suicide and Psychiatric Disorders Among Isotretinoin Users
JAMA dermatology, 2023 Key Points Question Is isotretinoin use associated with the risk of suicide and psychiatric disorders? Findings In this meta-analysis of 25 studies including 1 625 891 participants, the 1-year absolute risk of completed suicide, suicide attempt, suicide ...
N. Tan +4 more
semanticscholar +1 more source
Ocular side effects of systemic isotretinoin – a systematic review and summary of case reports
Journal of dermatological treatment (Print), 2023 Background: Isotretinoin is frequently used for treatment of severe nodulocystic and papulopustular acne, however use is limited by mucocutaneous, ocular, and systemic side effects. Objective: (1) provide a systematic meta-analysis of ocular side effects
Olivia Lamberg +6 more
semanticscholar +1 more source
Dendrimer-conjugated isotretinoin for controlled transdermal drug delivery
Journal of Nanobiotechnology, 2023 Background In the present study, we aimed to develop a novel isotretinoin delivery model for treating skin diseases, revealing its potential advantages in drug delivery and targeted therapy.
Tianqi Zhao +6 more
semanticscholar +1 more source
Experimental Dermatology, 2023 There are no drugs as effective as isotretinoin for acne. Deciphering the changes in the microbiome induced by isotretinoin in the pilosebaceous follicle of successfully treated patients can pave the way to identify novel therapeutic alternatives.
Z. Nolan +10 more
semanticscholar +1 more source
Adverse Events in Isotretinoin Therapy: A Single-Arm Meta-Analysis
International Journal of Environmental Research and Public Health, 2022 Isotretinoin (ISO) is an oral prescription-only retinoid, well known for its acne-treating effect. However, it affects a substantial number of human cell types, causing a broad spectrum of adverse effects.
J. Kapała +3 more
semanticscholar +1 more source
Archives of Dermatological Research, 2022 The transcriptomic regulation induced by isotretinoin (13-cis retinoic acid) is still a matter of debate as short-term exposures of immortalized sebocytes with isotretinoin produced conflicting results.
N. Agamia +9 more
semanticscholar +1 more source