Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway
Investigative Ophthalmology and Visual Science, 2022 Purpose To investigate the effects of isotretinoin on the ocular surface and to explore the possible mechanisms. Methods Rats were treated with isotretinoin 20 mg/kg/d for five months and tested monthly for tear secretion, fluorescein staining, and ...
Peng Zhang +7 more
semanticscholar +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Acta Dermato-Venereologica, 2023 Although isotretinoin has anti-inflammatory and immunomodulatory properties, it can exacerbate atopic dermatitis. National estimates of the extent to which patients with atopic dermatitis are affected by severe acne and isotretinoin tolerability are ...
Cathrine H. Mohn +4 more
doaj +1 more source
Comprehensive review of reports of menstrual irregularities associated with isotretinoin
International Journal of Women's Dermatology, 2020 In 1982, oral isotretinoin was first licensed as a treatment option for severe recalcitrant cystic acne in the United States. Since its introduction into the pharmaceutical market, several instances of amenorrhea in women of child-bearing age taking ...
Priya Chelliah, BA +1 more
doaj +1 more source
Premature ventricular contractions associated with isotretinoin use [PDF]
Anais Brasileiros de Dermatologia, 2016 Isotretinoin has been considered a unique drug for acne treatment. However, it is associated with numerous adverse effects. Isotretinoin can trigger premature ventricular contractions.
Sevil Alan +2 more
doaj +1 more source
A pilot study of chemoimmunotherapy in the postconsolidation setting for high-risk neuroblastoma (ANBL19P1): A report from the Children's Oncology Group. [PDF]
CancerAbstract Background Survival for patients with high‐risk neuroblastoma remains poor despite current‐era multimodality treatment that includes postconsolidation GD2‐directed immunotherapy. Given the promising responses in patients who receive dinutuximab‐based chemoimmunotherapy in the relapsed setting, the Children’s Oncology Group ANBL19P1 study ...
Desai AV +13 more
europepmc +2 more sources
Patients' Knowledge and Information Needs about Isotretinoin Therapy Use in Jordan
International journal of clinical practice, 2022 Background. Despite being the first‐line treatment for severe or moderate acne, isotretinoin has several serious side effects that necessitate the evaluation of patients’ knowledge about isotretinoin side effects and its proper use. Objective.
A. Jarab +3 more
semanticscholar +1 more source
, 1998 Acneiform dermatoses are follicular eruptions. The initial lesion is inflammatory, usually a papule or pustule. Comedones are later secondary lesions, a sequel to encapsulation and healing of the primary abscess.
Jansen, Thomas, Plewig, G.
core +1 more source
Severe osteoarticular involvement in isotretinoin-triggered acne fulminans: two cases successfully treated with anakinra. [PDF]
, 2017 Acne fulminans (AF) is a severe form of inflammatory and ulcerated acne associated with fever, malaise, joint swellings and polyarthralgia.1 Osteoarticular lesions are often described and can be radiologically indistinguishable from those observed in
Barbareschi +9 more
core +1 more source
Teratogenic effect of isotretinoin in both fertile females and males (Review).
Experimental and Therapeutic Medicine, 2021 Isotretinoin is an oral derivate of vitamin A that has been used since 1982 for the treatment of multiple dermatologic conditions such as severe acne, rosacea, scarring alopecia, ichthyosis or non-melanoma skin cancer prophylaxis. The recommended dose is
C. Drăghici +5 more
semanticscholar +1 more source