Results 1 to 10 of about 188,123 (308)

Isotype Heterojunction-Boosted CO2 Photoreduction to CO

Nano-Micro Letters, 2022
Photocatalytic conversion of CO2 to high-value products plays a crucial role in the global pursuit of carbon–neutral economy. Junction photocatalysts, such as the isotype heterojunctions, offer an ideal paradigm to navigate the photocatalytic CO2 ...
Chaogang Ban, Jiangping Ma, Kaiwen Wang   +2 more
exaly   +2 more sources

Machine learning predictions of IgG1 and IgG4 self-association and high-concentration solution properties [PDF]

mAbs
To meet the widespread demand for subcutaneous delivery of antibody therapeutics, candidates with low viscosity, high solubility, and/or low aggregation propensity in concentrated formulations must be identified.
Na-Young Kwon, Chloe N. Brown, Hsin-Ting Chen, Steven R. Cottle, Ronan M. Kelly, Bryan E. Jones, William F. Weiss, Peter M. Tessier   +7 more
doaj   +2 more sources

PTEN-mTORC2 signaling module controls antibody isotype selection and antiviral humoral immunity [PDF]

Frontiers in Immunology
IntroductionThe phosphoinositide 3-kinase (PI3K) pathway is a central regulator of activated B cells, yet how PI3K signal strength is interpreted within complex signaling networks to achieve appropriate antibody isotype selection and protective humoral ...
Bikash Thapa, Yejin Lee, Seongwon Pak, Dongkyu Kim, Hyung-Joo Kwon, Keunwook Lee, Keunwook Lee   +6 more
doaj   +2 more sources

IgA Plasma Cells Are Long-Lived Residents of Gut and Bone Marrow That Express Isotype- and Tissue-Specific Gene Expression Patterns

Frontiers in Immunology, 2021
Antibody secreting plasma cells are made in response to a variety of pathogenic and commensal microbes. While all plasma cells express a core gene transcription program that allows them to secrete large quantities of immunoglobulin, unique ...
Joel R. Wilmore, Joel R. Wilmore, Brian T. Gaudette, Daniela Gómez Atria, Rebecca L. Rosenthal, Sarah Kim Reiser, Wenzhao Meng, Aaron M. Rosenfeld, Eline T. Luning Prak, David Allman   +9 more
doaj   +1 more source

Marie Reidemeister and Otto Neurath: interwoven lives and work

European Journal of Life Writing, 2022
Otto Neurath and Marie Reidemeister were both part of an interdisciplinary team which developed the ‘Vienna Method of Pictorial Statistics’ (later known as Isotype).
Christopher Burke, Günther Sandner
doaj   +1 more source

Regulation of Tubulin Gene Expression: From Isotype Identity to Functional Specialization

Frontiers in Cell and Developmental Biology, 2022
Genomes of higher eukaryotes encode a large tubulin gene superfamily consisting of at least six α and six β-tubulin isotypes. While some α and β-tubulin isotypes are ubiquitously expressed, others are cell-type specific.
Ivana Gasic
doaj   +1 more source

Antibodies of the immunoglobulin a isotype to novel antigens in early axial spondyloarthritis

Frontiers in Medicine, 2023
IntroductionThere is an unmet need for biomarkers to identify patients with axial spondyloarthritis (axSpA). Increasing evidence suggest the presence of autoantibodies in a subset of axSpA patients.
Pieter Ruytinx, Patrick Vandormael, Dana Quaden, Elien Luyten, Piet Geusens, Piet Geusens, Johan Vanhoof, Anouk Agten, Frank Vandenabeele, Kurt de Vlam, Kurt de Vlam, Veerle Somers   +11 more
doaj   +1 more source

Expanding the Anti-Phl p 7 Antibody Toolkit: An Anti-Idiotype Nanobody Inhibitor

Antibodies, 2023
We have previously produced a toolkit of antibodies, comprising recombinant human antibodies of all but one of the human isotypes, directed against the polcalcin family antigen Phl p 7.
Susan K. Vester, Anna M. Davies, Rebecca L. Beavil, Balraj S. Sandhar, Andrew J. Beavil, Hannah J. Gould, Brian J. Sutton, James M. McDonnell   +7 more
doaj   +1 more source

Characterising the Phenotypic Diversity of Antigen-Specific Memory B Cells Before and After Vaccination

Frontiers in Immunology, 2021
The diversity of B cell subsets and their contribution to vaccine-induced immunity in humans are not well elucidated but hold important implications for rational vaccine design.
M. Christian Tjiam, Sonia Fernandez, Martyn A. French   +2 more
doaj   +1 more source

The Role of IgG Subclass in Antibody-Mediated Protection against Carbapenem-Resistant Klebsiella pneumoniae

mBio, 2020
Monoclonal antibodies (MAbs) have the potential to assist in the battle against multidrug-resistant bacteria such as carbapenem-resistant Klebsiella pneumoniae (CR-Kp).
Michael P. Motley, Elizabeth Diago-Navarro, Kasturi Banerjee, Sean Inzerillo, Bettina C. Fries   +4 more
doaj   +1 more source