Results 31 to 40 of about 188,123 (308)

THE ROLE OF POLYSACCHARIDE KRESTIN FROM Coriolus versicolor MUSHROOM ON IMMUNOGLOBULIN ISOTYPE OF MICE WHICH INFECTED BY Mycobacterium tuberculosis

Indonesian Journal of Tropical and Infectious Disease, 2015
This research was aimed to determine the role of polysaccharide krestin (PSK) with different timing on levels and types of mice immunoglobulin (Ig) isotype which infected by Mycobacterium tuberculosis.
Adita Ayu Permanasari
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Immunoglobulin isotype distribution.

, 2013
Immunoglobulin isotype distribution of antibodies secreted by plasmablasts reactive with Vi and O-9,12 antigen (ASC/106 PBMC) in 25 volunteers immunized with the Vi capsular polysaccharide, and with O-9,12 antigen in 25 volunteers immunized with the ...
Riitta Karttunen (400294), Jussi M. Kantele (328384), Sari H. Pakkanen (328383), Anu Kantele (133499)   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Human isotype‐dependent inhibitory antibody responses against Mycobacterium tuberculosis

EMBO Molecular Medicine, 2016
Accumulating evidence from experimental animal models suggests that antibodies play a protective role against tuberculosis (TB). However, little is known about the antibodies generated upon Mycobacterium tuberculosis (MTB) exposure in humans.
Natalie Zimmermann, Verena Thormann, Bo Hu, Anne‐Britta Köhler, Aki Imai‐Matsushima, Camille Locht, Eusondia Arnett, Larry S Schlesinger, Thomas Zoller, Mariana Schürmann, Stefan HE Kaufmann, Hedda Wardemann   +11 more
doaj   +1 more source

Pre-existing antitherapeutic antibodies against the Fc region of the hu14.18K322A mAb are associated with outcome in patients with relapsed neuroblastoma

Journal for ImmunoTherapy of Cancer, 2020
Purpose Patients with cancer receiving tumor-reactive humanized monoclonal antibody (mAb) therapy can develop a human antihuman antibody (HAHA) response against the therapeutic mAb.
Jacek Gan, Lakeesha Carmichael, KyungMann Kim, Anna Hoefges, Paul M Sondel, Amy K Erbe, Jacquelyn A Hank, Stephen D Gillies, Jacob L Goldberg, Fariba Navid, Victor Santana, Fenna de Bie, Amal M Javaid, Michael Merdler, Michael W Bishop, Michael M Meager, Janardan P Pandey   +16 more
doaj   +1 more source

Isotype subgroups of mixed groups [PDF]

, 2001
summary:In this paper, we initiate the study of various classes of isotype subgroups of global mixed groups. Our goal is to advance the theory of $\Sigma$-isotype subgroups to a level comparable to its status in the simpler contexts of torsion-free and ...
Ullery, William, Megibben, Charles
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Immunoglobulin A Isotype of Antiphospholipid Antibodies Does Not Provide Added Value for the Diagnosis of Antiphospholipid Syndrome in a Chinese Population

Frontiers in Immunology, 2020
ObjectiveAntiphospholipid syndrome (APS) is characterized by the presence of anti-phospholipid (aPL) antibodies. However, the relationship between the immunoglobulin (Ig) A isotype of aPL positivity and its clinical utility in APS diagnosis is ...
Chaojun Hu, Chaojun Hu, Xi Li, Xi Li, Jiuliang Zhao, Jiuliang Zhao, Qian Wang, Qian Wang, Mengtao Li, Mengtao Li, Xinping Tian, Xinping Tian, Xiaofeng Zeng, Xiaofeng Zeng   +13 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source