Results 211 to 220 of about 197,507 (284)

Blocking interleukin 33 reduces joint, systemic, and lung inflammatory responses in the combined collagen-induced arthritis-inhalant endotoxin exposure model. [PDF]

J Pharmacol Exp Ther
Poole JA, Larsen JL, Thiele GM, Wyatt TA, Nelson AJ, Duryee MJ, Gleason AM, Schanze OW, Schwab AD, Dickinson JD, Mosley D, Lush M, Wang HJ, Cohen ES, England BR, Mikuls TR.   +15 more
europepmc   +1 more source

Isotype Switching [PDF]

, 2008
openaire   +1 more source

Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1

Cytoskeleton, EarlyView.
ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley   +1 more source

Immunotherapy does not impair ovarian function in a mouse model of breast cancer. [PDF]

Front Reprod Health
De La Cruz P, Woodman-Sousa MF, McAdams JN, Sweeney E, Hakim L, Morales Aquino M, Grive KJ.   +6 more
europepmc   +1 more source

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

Co-Formulation of Pembrolizumab Murine Surrogate RMP1-14 with Imagent^® Ultrasound Contrast Agent Enhances Intratumoral Antibody Delivery Through a Transient Increase in Tumor Blood Perfusion. [PDF]

Pharmaceutics
Kirven IA, Penfornis P, Siddiqui MR, Butler KR, Roman RJ, Larsen CT, Howard CM, Claudio PP.   +7 more
europepmc   +1 more source

Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays

Cytoskeleton, EarlyView.
ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz, Benjamin Powers, Jayne Aiken   +2 more
wiley   +1 more source

Large-scale GWAS meta-analysis of serum antibody levels in healthy individuals reveals distinct genetic architectures. [PDF]

Genes Immun
Willis TW, Gkrania-Klotsas E, Wareham NJ, McKinney EF, Lyons PA, Smith KGC, Wallace C.   +6 more
europepmc   +1 more source

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Isolation of Human Umbilical Cord Blood Hematopoietic Stem Cells and Directed Differentiation Into Megakaryocytes. [PDF]

Bio Protoc
Xia W, Miao Z, Zhang W, Liu Z, Wu H, Fan Y.   +5 more
europepmc   +1 more source