Results 221 to 230 of about 188,123 (308)

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

Interdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang, Fan Zou, Mingdong Wang, Chenyue Wu, Yingwei Xie, Yongjun Quan, Wei Yan, Yupeng Zheng, Lianhua Li, Yuexin Liu, Jian Yu, Hao Ping   +11 more
wiley   +1 more source

Reinvigorating COTL1^high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours. [PDF]

Nat Cell Biol
You W, Hu C, Zhang Y, Huang Y, Yuan J, Wu CY, Kong D, Zhao M, Han Y, Li S, Shan R, Lu J, Cheng M, Li Q, Yao B, Yu XF, Xia Q, Chong W, Kuang DM, Chen Y.   +19 more
europepmc   +1 more source

Antibody Isotype [PDF]

, 2020
openaire   +1 more source

Pseudohyperphosphatemia in Multiple Myeloma: A Systematic Review of Case Reports and Case Series

Journal of Clinical Laboratory Analysis, EarlyView.
Pseudohyperphosphatemia (PHP) is a clinically significant laboratory artifact in patients with multiple myeloma (MM). It is often caused by paraprotein interference with phosphate assays. This systematic review summarizes reported cases, underlying mechanisms, and diagnostic approaches to distinguish spurious from true hyperphosphatemia.
Mahsa Dabir, Maryam Kamrani Mousavi, Mohana Mohamadi, Ali Maleki   +3 more
wiley   +1 more source

Adipose-derived mesenchymal stromal cells promote an exhaustion-associated phenotype in T cells through TIM-3 upregulation independent of PD-1. [PDF]

Discov Oncol
Mirshafiei S, Absalan F, Yousefi B, Shariat M, Talei AR, Baharlou R, Mehdipour F, Ghaderi A.   +7 more
europepmc   +1 more source

Biomarkers of Endothelial Damage in Acute Graft‐Versus‐Host Disease After Allogenic Hematopoietic Stem Cell Transplantation: Methodological Challenges

Journal of Clinical Laboratory Analysis, EarlyView.
Allogeneic hematopoietic stem cell transplantation remains a potentially curative therapy for many hematological malignancies; however, its success is significantly limited by acute graft‐versus‐host disease (aGVHD), a leading cause of post‐transplant morbidity and mortality in which endothelial dysfunction plays a central role.
Katarina Klinar, Helena Podgornik
wiley   +1 more source

Correction: A novel extracellular role for tissue transglutaminase in matrix-bound VGF-mediated angiogenesis. [PDF]

Cell Death Dis
Wang Z, Perez M, Caja S, Melino G, Johnson TS, Lindfors K, Griffin M.   +6 more
europepmc   +1 more source

Histological Analysis of Cryopreserved Venous Allografts Used for Liver Transplantation and Hepato‐Biliary‐Pancreatic Surgery

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Cryopreserved venous allografts, which we pioneered in 1999 for use in living donor liver transplantation and hepato‐biliary‐pancreatic surgery, are widely used and are believed to preserve vascular architecture with minimal anticoagulation or immunosuppression requirements and patency comparable to autologous grafts.
Yusuke Seki, Akihiko Ichida, Sumihito Tamura, Mariko Tanaka, Yoshinori Inagaki, Kyoji Ito, Rihito Nagata, Takuya Hashimoto, Nobuhisa Akamatsu, Tetsuo Ushiku, Kiyoshi Hasegawa   +10 more
wiley   +1 more source

TREM1-PET imaging maps whole-body innate immune responses in a mouse model of metastatic melanoma. [PDF]

Sci Rep
Falk IN, Chaney AM, Verma R, Kuo RC, Reyes S, Carlson M, Kalita M, Azevedo C, Jackson IM, Green J, Alam IS, Tran A, Pant A, Deal EM, Lim M, James ML.   +15 more
europepmc   +1 more source

Transient gingival inflammation is associated with epithelial dysfunction and systemic immune activation beyond clinical improvement

Journal of Periodontology, EarlyView.
Abstract Background The oral cavity significantly influences systemic health. Gingivitis, an early reversible stage of periodontal disease, may trigger systemic immune changes by facilitating bacterial translocation. This study examined the immune responses elicited by experimental gingivitis and their systemic immune impact, specifically in relation ...
Omnia Elebyary, Rachel Liu, Jinny Tsang, Chunxiang Sun, Bryan Coburn, Michael Glogauer   +5 more
wiley   +1 more source