Results 241 to 250 of about 20,504 (258)

Synthesis of 4-Sulfenyl Isoxazoles through AlCl3-Mediated Electrophilic Cyclization and Sulfenylation of 2-Alkyn-1-one O-Methyloximes.

Journal of Organic Chemistry, 2019
An efficient method for the synthesis of 4-sulfenyl isoxazoles has been developed via AlCl3-mediated electrophilic cyclization/sulfenylation of 2-alkyn-1-one O-methyloximes.
Wenchao Gao, Yu-Fei Cheng, Hong‐Hong Chang, Xing Li, Wenlong Wei, Peng Yang   +5 more
semanticscholar   +1 more source

Gold-Catalyzed [4 + 1]-Annulation Reactions between 1,4-Diyn-3-ols and Isoxazoles To Construct a Pyrrole Core.

Organic Letters, 2018
This work reports gold-catalyzed [4 + 1]-annulation reactions between 1,4-diyn-3-ols and isoxazoles or benzisoxazoles to yield pyrrole derivatives. The reaction chemoselectivity is controlled by an initial attack of an isoxazole at a less hindered alkyne
Rahul Dadabhau Kardile, Balaji S. Kale, Pankaj Sharma, Rai‐Shung Liu   +3 more
semanticscholar   +1 more source

Sea Urchin Embryo Model As a Reliable in Vivo Phenotypic Screen to Characterize Selective Antimitotic Molecules. Comparative evaluation of Combretapyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles as Tubulin-Binding Agents.

ACS Combinatorial Science, 2018
A series of both novel and reported combretastatin analogues, including diarylpyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles, were synthesized via improved protocols to evaluate their antimitotic antitubulin activity using in vivo sea urchin ...
M. Semenova, D. Demchuk, D. V. Tsyganov, N. B. Chernysheva, A. V. Samet, E. A. Silyanova, V. P. Kislyi, A. S. Maksimenko, A. E. Varakutin, L. Konyushkin, M. M. Raihstat, A. Kiselyov, V. Semenov   +12 more
semanticscholar   +1 more source

Continuous Flow Synthesis of Isoxazoles via Vinyl Azides from Friedel-Crafts Acylation of Alkynes: A Modulated Troubleshooting Optimization Approach.

Organic Letters, 2019
The synthesis of isoxazoles has been achieved in a continuous flow system composed of two reaction units: the Friedel-Crafts acylation of alkynes and the azide conjugate addition to the resulting β-chlorovinyl ketones followed by a photochemical-thermal ...
H. Koo, H. Kim, K. Oh
semanticscholar   +1 more source

Copper-Catalyzed [4+2]-Cycloadditions of Isoxazoles with 2-Alkynylbenzaldehydes To Access Distinct α-Carbonylnaphthalene Derivatives: C(3,4)- versus C(4,5)-Regioselectivity at Isoxazoles

ACS Catalysis, 2019
Cu(II)-catalyzed [4+2]-cycloadditions occur between Cu–benzopyryliums and substituted isoxazoles with the regioselectivity on the C(3,4)-carbons of isoxazoles.
Sovan Sundar Giri, Rai‐Shung Liu
semanticscholar   +1 more source

Synthetic Approaches to Nitro-Substituted Isoxazoles

Synthesis, 2019
Nitro-substituted isoxazoles are of utmost interest both as versatile intermediates for targeted organic synthesis and as perspective bioactive compounds for drug development.
D. Vasilenko, K. Sedenkova, T. Kuznetsova, E. Averina   +3 more
semanticscholar   +1 more source

Harnessing Stereospecific Z-Enamides through Silver-Free Cp*Rh(III) Catalysis by Using Isoxazoles as Masked Electrophiles.

Organic Letters, 2019
The stereospecific synthesis of Z-enamides is described in this paper. For the first time, isoxazoles have been employed as electrophiles in C-H functionalization to afford thermodynamically less stable Z-enamides utilizing salicylaldehydes in an atom ...
Suvankar Debbarma, S. S. Bera, M. Maji
semanticscholar   +1 more source

Pyruvic acid-catalyzed one-pot three-component green synthesis of isoxazoles in aqueous medium: a comparable study of conventional heating versus ultra-sonication

Proceedings of the Indian Academy of sciences. Chemical sciences, 2022
S. Deshmukh, A. Nalkar, S. Thopate
semanticscholar   +1 more source

Synthesis of 3-Acyl-isoxazoles and Δ2-Isoxazolines from Methyl Ketones, Alkynes or Alkenes, and tert-Butyl Nitrite via a Csp3-H Radical Functionalization/Cycloaddition Cascade.

Organic Letters, 2019
A novel metal-free tandem Csp3-H bond functionalization of ketones and 1,3-dipolar cycloaddition has been developed. An efficient approach to a variety of oxazole and isoxazoline derivatives is demonstrated using the 1,3-dipolar cycloaddition of alkynes ...
P. Dai, Xin Tan, Qian Luo, Xiang Yu, Shuguang Zhang, Fang Liu, Weihua Zhang   +6 more
semanticscholar   +1 more source

The main directions and recent trends in the synthesis and use of isoxazoles

Chemistry of Heterocyclic Compounds, 2020
O. B. Bondarenko, N. Zyk
semanticscholar   +1 more source