Results 241 to 250 of about 20,875 (302)
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2001
Publisher Summary Natural products based on the isoxazole (1,2-oxazole) skeleton constitute a small, heterogeneous group of natural products encompassing at present more than 90 structures. This group has not traditionally been classified as a special alkaloid group and has never been reviewed as a group previously.
L, Rahbaek, C, Christophersen
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Publisher Summary Natural products based on the isoxazole (1,2-oxazole) skeleton constitute a small, heterogeneous group of natural products encompassing at present more than 90 structures. This group has not traditionally been classified as a special alkaloid group and has never been reviewed as a group previously.
L, Rahbaek, C, Christophersen
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Organic Letters, 2019
We have presented a simple and new method for the divergent assembly of furoxans and isoxazoles in which the [2 + 1 + 1 + 1] annulation reaction of sulfoxonium ylides is reported for the first time.
Zhonghe Tang, Yao Zhou, Q. Song
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We have presented a simple and new method for the divergent assembly of furoxans and isoxazoles in which the [2 + 1 + 1 + 1] annulation reaction of sulfoxonium ylides is reported for the first time.
Zhonghe Tang, Yao Zhou, Q. Song
semanticscholar +1 more source
Isoxazoles with antipicornavirus activity
Journal of Medicinal Chemistry, 1985The synthesis and evaluation of a series of 3,5-disubstituted isoxazoles as antipicornavirus agents have led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 was found more effective than 4',6-dichloroflavan against both viruses and was evaluated orally in mice infected ...
G D, Diana +5 more
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Angewandte Chemie, 2019
6π electrocyclization has attracted considerable interest in organic synthesis because of its high stereospecificity and atom economy in the construction of versatile 5- to 7-membered cycles.
Xinhai Zhu +5 more
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6π electrocyclization has attracted considerable interest in organic synthesis because of its high stereospecificity and atom economy in the construction of versatile 5- to 7-membered cycles.
Xinhai Zhu +5 more
semanticscholar +1 more source
2022
Isoxazoles, isoxazolines and isoxazolidines are a class of heterocyclic compounds having a remarkable number of applications and are very versatile building blocks in organic synthesis. The developments concerning the synthesis of the above monocyclic systems reported in the literature from 2007 to 2019 are reviewed.
Cordero, Franca M. +2 more
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Isoxazoles, isoxazolines and isoxazolidines are a class of heterocyclic compounds having a remarkable number of applications and are very versatile building blocks in organic synthesis. The developments concerning the synthesis of the above monocyclic systems reported in the literature from 2007 to 2019 are reviewed.
Cordero, Franca M. +2 more
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Isoxazole is a versatile five-membered heterocyclic compound that has attracted significant attention due to its diverse medicinal chemistry and material science applications. This chapter provides a comprehensive overview of synthetic methodologies for preparing isoxazole derivatives, including traditional approaches such as cyclization reactions and ...
Erum Akbar Hussain +2 more
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Erum Akbar Hussain +2 more
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Journal of Organic Chemistry, 2019
An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4' H-spiro[indole-3,5'-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and ...
Alexander V Aksenov +8 more
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An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4' H-spiro[indole-3,5'-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and ...
Alexander V Aksenov +8 more
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Iterative Assembly of Nitrile Oxides and Ynamides: Synthesis of Isoxazoles and Pyrroles.
Journal of Organic Chemistry, 2019Described is an iterative assembly of nitrile oxides and ynamides for the synthesis of isoxazoles and pyrroles. The nitrile oxides could undergo Cu(I)-free cyclization with terminal ynamides for accessing isoxazoles, which could engage in another ...
Changwei Chen, Sunliang Cui
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Oxazolo[4,5-d]isoxazole Derivatives and 3,4-Disubstituted Isoxazoles from Isoxazol-5(4H)-ones
Synthetic Communications, 1993Abstract Synthesis for oxazolo[4,5-d]isoxazole derivatives and 3,4-disubstituted isoxazoles from isoxazol-5(4H)-ones is reported.
E.M. Beccalli, A. Marchesini, T. Pilati
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Isoxazole Ionotropic Glutamate Neurotransmitters
Current Medicinal Chemistry, 2005Analogs of the excitatory neurotransmitter glutamate are potential medicinal agents for a wide variety of neurological disorders. The isoxazole glutamate derivatives represent an important class of compounds because of their receptor specificity and binding affinity. Since the discovery of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid (
David J, Burkhart, N R, Natale
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