Results 31 to 40 of about 3,055 (208)

Bicyclic Isoxazoline Derivatives: Synthesis and Evaluation of Biological Activity

Molecules, 2022
The application of non-planar scaffolds in drug design allows for the enlargement of the chemical space, and for the construction of molecules that have more effective target–ligand interactions or are less prone to the development of resistance.
Kseniya N. Sedenkova, Kristian S. Andriasov, Marina G. Eremenko, Yuri K. Grishin, Vera A. Alferova, Anna A. Baranova, Nikolay A. Zefirov, Olga N. Zefirova, Vladimir V. Zarubaev, Yulia A. Gracheva, Elena R. Milaeva, Elena B. Averina   +11 more
doaj   +1 more source

Navigating Nitration Chemistry: A Practical Guide to Reagents, Mechanisms, and Selectivity

Angewandte Chemie, EarlyView.
This review highlights key contributions of modern nitration chemistry, emphasizing sustainable mechanistic platforms and comparing the performance of both organic and inorganic reagents across aromatic, ipso‐, olefin, alkyne, and heteroatom nitration. It provides the community with a clearer, unified perspective on current advances and facilitates the
Harry Lecomte, Anthony J. Fernandes, Dmitry Katayev   +2 more
wiley   +2 more sources

A one-pot synthesis of 3-trifluoromethyl-2-isoxazolines from trifluoromethyl aldoxime

Beilstein Journal of Organic Chemistry, 2013
Functionalized 3-trifluoromethyl-2-isoxazolines and 3-trifluoromethylisoxazoles were easily prepared from trifluoromethyl aldoxime 2 under mild conditions by using DIB as oxidant.
Raoni S. B. Gonçalves, Michael Dos Santos, Guillaume Bernadat, Danièle Bonnet-Delpon, Benoit Crousse   +4 more
doaj   +1 more source

Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives [PDF]

, 2012
10.1186/1472-6769-12-5BMC Chemical ...
Anilkumar, N.C., Basappa, Li, F., Manu, K.A., Nanjundaswamy, S., Prasanna, D.S., Rangappa, K.S., Sadashiva, M.P., Sengottuvelan, M., Sethi, G., Sugahara, K.   +10 more
core   +3 more sources

Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocylces [PDF]

, 2014
Chalcones belong to the flavonoid family which constitutes one of the major classes of naturally occurring oxygen heterocyclic compounds. The alpha,beta-unsaturated carbonyl system of chalcones possesses two electrophilic reactive centers allowing them ...
Albuquerque, Hélio, Cavaleiro, José, Santos, Clementina M.M., Silva, Artur   +3 more
core   +1 more source

Steroid [16, 17-c]isoxazoline

Chemical and Pharmaceutical Bulletin, 1964
5'-Methyl-5α-androstano[16, 17-c]isoxazolin-3β-ol (Va) and 5'-methylandrost-5-eno[16, 17-c]isoxazolin-3β-ol (Vb), were obtained by treatment of 3β, 20α-dihydroxy-5α-pregnan-16-one 3-acetate 16-oxime (IIIa) or 3β, 20α-dihydroxypregn-5-en-16-one 3-acetate 16-oxime (IIIb) with tosyl chloride in pyridine followed by alkaline hydrolysis. Oxidation of Va and
S, NOGUCHI, M, IMANISHI, K, MORITA
openaire   +3 more sources

A comparative laboratory trial evaluating the immediate efficacy of fluralaner, afoxolaner, sarolaner and imidacloprid + permethrin against adult Rhipicephalus sanguineus (sensu lato) ticks attached to dogs [PDF]

, 2012
Variational methods are used for targeting specific correlation effects by tailoring the configuration space. Independent sets of correlation orbitals, embedded in partitioned correlation functions (PCFs), are produced from multiconfiguration Hartree-
Froese Fischer, Charlotte, Gaigalas, Gediminas, Godefroid, Michel, Jönsson, Per, Rynkun, Pavel, Verdebout, Simon   +5 more
core   +1 more source

Synthesis and Application of Bioactive N-Functionalized Aziridines. [PDF]

Angew Chem Int Ed Engl
This review discusses modern synthetic methods for the preparation of aziridine‐containing small molecules, including biocatalytic, electrocatalytic, and photocatalytic strategies. We highlight the compatibility of various synthetic methods with control of the exocyclic N‐substituent.
Tan H, Samanta S, Qiu N, Adibekian A, Powers DC.   +4 more
europepmc   +2 more sources

1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones [PDF]

, 2010
1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones is described. A series of novel isoxazolines are isolated from the nitrile oxide cycloadditions, whilst the isoxazolines generated from the nitrone cycloadditions ...
Kissane, Marie, Lawrence, Simon E., Maguire, Anita R.   +2 more
core   +1 more source

Synthesis and antibacterial studies of some novel isoxazoline derivatives [PDF]

Journal of the Serbian Chemical Society, 2007
A series of 3-[3-(2,4-dichloro-5-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-(substituted phenyl/2-thienyl)isoxazolines (4a-j) were prepared. The structures of the isoxazoline derivatives were confirmed on the bases of elemental analysis and
TEJASKUMAR SHAH, VIKAS DESAI
doaj   +3 more sources