Results 11 to 20 of about 3,055 (208)

Effective treatment with afoxolaner (NexGard) of Trixacarus caviae in a pet guinea pig [PDF]

Veterinary Medicine and Science
Trixacarus caviae is a sarcoptic mange mite infesting guinea pigs. Infestation in immunosuppressed animals produces severe dermatological problems, including alopecia, intense pruritus, hyperkeratosis and non‐dermatological issues (e.g., seizures ...
Georgiana Deak, Miruna‐Maria Matei, Anca‐Alexandra Doboși, Aura Livia Ursache, Andrada Negoescu, Marian Taulescu   +5 more
doaj   +2 more sources

Efficacy of a short-acting oral fluralaner formulation (WellPet™) against fleas and brown dog ticks in controlled and field conditions [PDF]

Frontiers in Veterinary Science
BackgroundFluralaner is an isoxazoline widely used for flea and tick control in dogs, mainly in long-acting formulations. However, the performance of short-acting, lower-dose options remains unexplored in scientific literature.
Isabelle Vilela Bonfim, Breno Cayeiro Cruz, Igor Renan Honorato Gatto, Debora Azevedo Borges, Monique Taveira Medeiros, Gessica Ariane de Melo Cruz, Juliana Aparecida do Carmo Emidio Moreira da Silva, Clara Rodrigues Dutra, Carlos Eduardo Marques de Oliveira Filho, Ygor Henrique da Silva, Brena Gava Guimarães, Marcus Antonio Martins Buso, Ferdinando Nielsen de Almeida, Thais Ribeiro Correia, Fabio Barbour Scott, Diefrey Ribeiro Campos   +15 more
doaj   +2 more sources

Energetic Aspects and Molecular Mechanism of 3-Nitro-substituted 2-Isoxazolines Formation via Nitrile N-Oxide [3+2] Cycloaddition: An MEDT Computational Study [PDF]

Molecules
Regioselectivity and the molecular mechanism of the [3+2] cycloaddition reaction between nitro-substituted formonitrile N-oxide 1 and electron-rich alkenes were explored on the basis of the wb97xd/6-311+G(d) (PCM) quantum chemical calculations.
Ewa Dresler, Aneta Wróblewska, Radomir Jasiński   +2 more
doaj   +2 more sources

Effectiveness of lotilaner on furuncular myiasis in dogs naturally infested with Dermatobia hominis (Diptera: Cuterebridae) [PDF]

Revista Brasileira de Parasitologia Veterinária
An evaluation was made of the larvicidal efficacy of lotilaner (Credeli®) in the treatment of dogs naturally infested with Dermatobia hominis larvae. A total of 12 dogs presenting at least three live D. hominis larvae were medicated.
Rafaella Tortoriello, Luisa Xavier Christ, Victoria Caroline de Almeida Marques, Bruna Sampaio Martins, Julio Israel Fernandes   +4 more
doaj   +2 more sources

Centripetal Axonal Transport as a Gateway to the CNS for Veterinary Antiparasitics: Bypassing the Blood-Brain Barrier, Clinical Impact in Vulnerable Age Groups, and the Potential Facilitating Role of PFAS. [PDF]

J Toxicol
The widespread use of veterinary antiparasitics, including neonicotinoids, isoxazolines, avermectins, and pyrethroids, is essential for canine health but raises concerns regarding potential neurotoxicity, particularly in young and geriatric animals.
Britti D, Marabelli R, Calzetta L.
europepmc   +2 more sources

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Pharmaceuticals, 2023
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates.
Xiyue Wang, Qingyun Hu, Hui Tang, Xinhui Pan   +3 more
doaj   +1 more source

in silico Study Reveals Potential Docking Sites of δ 2-isoxazolines derivates for Inhibiting Russell’s Viper PLA2 Toxin [PDF]

Journal of Tropical Life Science, 2021
Snake venom phospholipase A2s (svPLA2s) has been known as the most abundant component and predominant cause of Russell’s viper envenomation. Limitation to serum therapy and considerable pharmacological interest led the researcher to syn-thesized multi ...
Tsaniyah Nur Kholilah, Widodo, Nia Kurniawan   +2 more
doaj   +1 more source

Efficacy of Oral Sarolaner for the Treatment of Feline Otodectic Mange

Pathogens, 2021
Otodectes cynotis is a mite with a cosmopolitan distribution that is the primary agent for the development of otitis externa in feline species. The aim of this study was to evaluate the efficacy of the oral administration of sarolaner for the treatment ...
Diefrey Ribeiro Campos, Jéssica Karoline de Oliveira Chaves, Brena Gava Guimarães, So Yin Nak, Gabriela Pereira Salça de Almeida, Isabela Scalioni Gijsen, Juliana de Moraes Intrieri, Fabio Barbour Scott   +7 more
doaj   +1 more source

3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles

Molecules, 2021
In this study, 3-benzoylisoxazolines were synthesized by reacting alkenes with various α-nitroketones using chloramine-T as the base. The scope of α-nitroketones and alkenes is extensive, including different alkenes and alkynes to form various ...
Xinhui Pan, Xiaobing Xin, Ying Mao, Xin Li, Yanan Zhao, Yidi Liu, Ke Zhang, Xiaoda Yang, Jinhui Wang   +8 more
doaj   +1 more source

Novel Synthesis of Dihydroisoxazoles by p-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones

Molecules, 2023
This article reports in detail a method for the synthesis of 3-benzoxoxazoline by the reaction of alkenes (alkynes) and a variety of α-nitroketones in the presence of p-TsOH. The scope of alkenes is broad, including different alkenes and the alkyne. This
Caiyun Yang, Sirou Hu, Xinhui Pan, Ke Yang, Ke Zhang, Qingguang Liu, Xiaobing Xin, Jie Li, Jinhui Wang, Xiaoda Yang   +9 more
doaj   +1 more source