Results 1 to 10 of about 1,834 (212)

Nitrile Oxide, Alkenes, Dipolar Cycloaddition, Isomerization and Metathesis Involved in the Syntheses of 2-Isoxazolines [PDF]

Molecules, 2023
The involvement of 1,3-dipolar cycloaddition (1,3-DP), double bond migration, metathesis, and nitrile oxide (including in situ-generated nitrile oxide) as dipoles, together with the C=C bond containing dipolarophiles, in the syntheses of 2-isoxazolines ...
Stanisław Krompiec, Piotr Lodowski, Aneta Kurpanik-Wójcik   +2 more
exaly   +5 more sources

Asymmetric Synthesis of Functionalized 2‑Isoxazolines [PDF]

ACS Omega
The asymmetric synthesis of the isoxazoline skeleton was achieved by the oxidation of hydroxylaminoalkyl furan prepared from simple starting materials: 2-methylfuran and (S)-epichlorohydrin. The synthesis features an NBS-mediated oxidation of hydroxylaminoalkyl furan to give an α,β-unsaturated ketone intermediate which cyclized to the isoxazoline.
Beyza Hamur, Fatma Albayrak Halac, Fethiye Yilmazer, Fraser F. Fleming, Irem Kulu, Ramazan Altundas   +5 more
doaj   +4 more sources

An easy access to chromano-isoxazolines and functionalized isoxazolines [PDF]

ARKIVOC, 2004
2-Allyloxybenzaldoximes on treatment with ceric ammonium nitrate (CAN) at room temperature afforded 3a,4-dihydro-3H-chromeno[4,3-c]isoxazoles while benzaldoximes on interaction with Baylis-Hillman adduct in the presence of CAN produced functionalized isoxazolines.
Biswanath Das, Gurram Mahender, Harish Holla, Joydeep Banerjee   +3 more
doaj   +2 more sources

Pharmacology and toxicology of veterinary isoxazolines: a review [PDF]

International Journal for Parasitology: Drugs and Drug Resistance
Isoxazoline derivatives have rapidly become cornerstone ectoparasiticides in veterinary medicine, providing high efficacy and long-lasting protection against fleas, ticks, and other arthropods in companion animals and, more recently, in food-producing ...
Paulina Markowska-Buńka, Bartosz Rasiński, Hubert Ziółkowski   +2 more
doaj   +2 more sources

Comparative analysis of isoxazoline activity on human and canine GABA receptors expressed in Xenopus oocytes [PDF]

Parasites & Vectors
Background Isoxazolines, including sarolaner, lotilaner, afoxolaner and fluralaner, are a class of ectoparasiticides that target gamma-aminobutyric acid receptors (GABARs) in insects and acari.
Heinz Sager, Anouk Sarr, Emmanuelle Kuntz, Lucien Rufener   +3 more
doaj   +2 more sources

Ultrasound-assisted one-pot three-component synthesis of new isoxazolines bearing sulfonamides and their evaluation against hematological malignancies

Ultrasonics Sonochemistry, 2021
In the present study, following a one-pot two-step protocol, we have synthesized novel sulfonamides-isoxazolines hybrids (3a-r) via a highly regioselective 1,3-dipolar cycloaddition. The present methodology capitalized on trichloroisocyanuric acid (TCCA)
Aicha Talha, Guillaume Robert, Patrick Auberger   +2 more
exaly   +3 more sources

Solid-phase synthesis of isoxazolines

Journal of Combinatorial Chemistry, 2002
The polymer-supported synthesis of isoxazolines is described via nitrile oxide intermediates, starting from primary nitroalkanes in a one-pot ...
Reddy, M. Venkat, Raza, Abbas, Yadav, J. S., Chandrasekhar, S., Venkat Reddy, M.   +4 more
core   +3 more sources

Effects of RDL GABA Receptor Point Mutants on Susceptibility to Meta-Diamide and Isoxazoline Insecticides in Drosophila melanogaster [PDF]

Insects
Ionotropic γ-aminobutyric acid (GABA) receptors in insects, specifically those composed of the RDL (resistant to dieldrin) subunit, serve as important targets for commonly used synthetic insecticides. These insecticides belong to various chemical classes,
Tianhao Zhou, Weiping Wu, Suhan Ma, Jie Chen, Jia Huang, Xiaomu Qiao   +5 more
doaj   +2 more sources

The mosquitocidal activity of isoxazoline derivatives afoxolaner, lotilaner, and fluralaner are not affected by mosquito sugar or antibiotic treatment [PDF]

Scientific Reports
Long-lasting insecticidal nets and indoor residual sprays have played a major role in significantly reducing the burden of malaria. However, the management of mosquitoes resistant to current insecticides continues to be challenging.
Harouna Soré, Wamdaogo Moussa Guelbeogo, Soumanaba Zongo, Judith M. Bolscher, Nicolas Ouédraogo, Adama Gansané, Teun Bousema, Katharine A. Collins, Koen J. Dechering   +8 more
doaj   +3 more sources

A Comprehensive Study of the Synthesis, Spectral Characteristics, Quantum–Chemical Molecular Electron Density Theory, and In Silico Future Perspective of Novel CBr₃-Functionalyzed Nitro-2-Isoxazolines Obtained via (3 + 2) Cycloaddition of (E)-3,3,3-Tribromo-1-Nitroprop-1-ene [PDF]

Molecules
The search for new heterocyclic compounds with biological potential is one of the current challenges in modern chemistry. Therefore, the comprehensive study of (3 + 2) cycloaddition (32CA) reactions between a series of aryl-substituted nitrile N-oxides ...
Karolina Zawadzińska-Wrochniak, Karolina Kula, Mar Ríos-Gutiérrez, Bartłomiej Gostyński, Tomasz Krawczyk, Radomir Jasiński   +5 more
doaj   +2 more sources